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All Journal JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Farmasi Higea
Maria Dona Octavia
Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pengaruh Kombinasi Magnesium Stearat dan Talkum sebagai Lubrikan terhadap Profil Disolusi Tablet Ibuprofen Syofyan Syofyan; Tri Yanuarto; Maria Dona Octavia
Jurnal Sains Farmasi & Klinis Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (496.862 KB) | DOI: 10.29208/jsfk.2015.1.2.35

Abstract

A research has been conducted on the combination effect of magnesium stearate and talc as a lubricant to the dissolution profile of Ibuprofen tablets. Of the three formulas made Ibuprofen tablets with wet granulation method. Evaluation of tablets include uniformity of size, weight uniformity, tablet hardness, disintegration, friability of tablets, assay and dissolution. Results of dissolution percentage was done up to 60 indicated that the dissolution the average was 95,72%, 97,65% and 99,93% consecutively for F I, F II and F III. In addition, result of the dissolution efficiency up to 60 minutes for each formula was 82,10%, 87,58%, and 90,76%. According to the dissolution of the data, formula III which had the highest dissolution results compared to formula I and formula II, which likely due to the ratio of the combination of magnesium stearate and talc as a lubricant smaller levels of magnesium stearate.
Pembentukan Sistem Dispersi Padat Amorf Azitromisin Dihidrat dengan Hikroksipropil Metilselulosa (HPMC) Erizal Zaini; Netty Novitasari; Maria Dona Octavia
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (575.168 KB) | DOI: 10.29208/jsfk.2017.3.2.140

Abstract

The aim of present study is to develop solid dispersion system of azithromycin dihydrate with hydroxypropyl methylcellulose E5 LV (HPMC) for improving the dissolution rate of azithromycin dihydrate. Amorphous solid dispersions were prepared by solvent method at 1:1; 1:2 and 2:1 (w/w) drug to polymer ratios. Solid state properties of amorphous solid dispersion were evaluated by X-ray powder diffraction (XRPD), scanning electron microscopy and spectroscopy FT-IR. Furthermore, the dissolution rate profile was investigated by type II USP dissolution apparatus. Based on X-ray powder diffractometry analysis, azithromycin dihydrate was transformed partially from the crystalline phase to the amorphous state as confirmed by significant reduction of the crystalline peaks intensity. FT-IR spectroscopy analysis revealed the absence of chemical interaction between azithromycin dihydrate and HPMC. The dissolution rate of azithromycin dihydrate from amorphous solid dispersion was substantially higher than azithromycin dihydrate intact and its physical mixture. The dissolution rate of azithromycin dihydrate increased with an increasing drug to polymer ratio.
Co-Authors Auzal Halim Auzal Halim Auzal Halim Erizal Zaini Firmansyah Firmansyah Fitriani Fitriani Friardi Ismed Harrizul Rivai Iin Indah Sari Kiki Rizky Wirza Maizel Fitri Marlani Marlani Monica Afrinda Netty Novitasari Novi Rini Novita Resita Sandra Rika Indriyani Riri Hariyani Sari Kartika Sri Kartika Ayu Stephany Stephany Syofyan Syofyan Tri Yanuarto Vike Zulia Putri Vina Oktavia Yeni Novita Sari Yuliana Yuliana Zilfia Zilfia