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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Makara Journal of Science
Indah D Dewijanti, Indah D
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Agriculture, Biological Sciences & Forestry Environmental Science

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Acute Toxicity Studies of Brucea javanica Merril Leaves Extract on Mice Angelina, Marissa; Dewijanti, Indah D; S, Banjarnahor S D; megawati, Megawati; Yuliani, Tri
Journal of Tropical Life Science Vol 2, No 2 (2012)
Publisher : Journal of Tropical Life Science

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Toxicological Evaluation of Tetrameles nudiflora Methanolic Extract Banjarnahor, Sofna Dewita Sari; Dewijanti, Indah D; Angelina, Marissa; Megawati, Megawati; Fajriah, Sofa
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

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Exploration of Mekongga national park resulted in novel finding of anticancer property from Tetrameles nudiflora. The investigation of toxic features of T. nudiflora is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of T. nudiflora in DDY mice. Animals were divided into 5 groups: Group 1 was given 1 ml solution of 2.5% Tween 80 in a single oral dose; Group 2, 3, 4 and 5 were orally administrated a single dose of 1, 2, 4 and 8 g/kg body weight T. nudiflora, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 22% of the male group, and 11% within the female group. The T.nudiflora extracts tested for toxicity against brine shrimp had 50% lethal concentration (LC50) values of 46.67 μg/ml. It can be concluded that methanol extracts of T. nudiflora are potential to be explored as anticancer (LC50=46.67 μg/ml). The extract is slightly toxic in male mice with Lethal Dose 50 (LD50) 12.6 g/kg body weight, and practically non toxic for female (LD50>15 g/kg body weight).Key words : Tetrameles nudiflora, brine shrimp lethality test, acute oral toxicity, LD 50.
PENENTUAN LD50 DAUN CINCO (Cyclea barbata Miers.) PADA MENCIT Angelina, Marissa; Hartati, Sri; Dewijanti, Indah D; Banjarnahor, Sofna D.S.; Meilawati, Lia
Makara Journal of Science Vol. 12, No. 1
Publisher : UI Scholars Hub

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LD50 of Cinco (Cyclea barbata Miers.) Leaf on Mice. The acute toxicity of ethanol extract of Cyclea barbata Miers. (Cb) leaves has been carried out on mice. The extract was administered by oral route in 4 different doses, i.e. 300 mg/kg BW, 1500 mg/kg BW, 3000 mg/kg BW, 30000 mg/kg BW. The toxic effect of the extract were evaluated by observation of behaviour, spinal reflexes, central nervous system, urination, and defecation, and also number of dead animal. The observation period lasted for 14 days. The results showed that up to 30000 mg/kg BW, the test material did not cause any significant toxic effects. The LD50 of the cyclea barbata Miers. leaves on mice was found to be more than 30000 mg/kg BW
Co-Authors Lia Meilawati Marissa Angelina Megawati - S, Banjarnahor S D Sofa Fajriah Sofna D.S. Banjarnahor Sofna Dewita Sari Banjarnahor, Sofna Dewita Sari Sri Hartati Tri Yuliani, Tri