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All Journal journal of internal medicine Jurnal Kedokteran Brawijaya The Indonesian Biomedical Journal Majalah Kesehatan FKUB The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy CRJIM (Clinical and Research Journal in Internal Medicine) Journal of Social Interactions and Humanities (JSIH) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

Supriono Supriono

Division Of Gastroentero-hepatology, Department Of Internal Medicine, Faculty Of Medicine, Universitas Brawijaya/Dr. Saiful Anwar Hospital, Malang

Author-ID : 5286940

Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 19 Documents Claim Missing Document

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Effects of Curcumin against Matrix Metalloproteinase-2 (MMP-2) and Tissue Inhibitor Metalloproteinase-2 (TIMP-2) Serum Level on Rat Model of Liver Fibrosis Resolution Process Supriono, Supriono; Pratomo, Bogi; Kriestian, Muhammad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 19, No 1 (2018): VOLUME 19, NUMBER 1, April 2018
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Background: Liver fibrosis is an effect from continuous fibrogenesis and fibrolysis process. During fibrogenesis, MMP-2 and TIMP-2 that produced by hepatic stellate cell (HSC) have a role to regulate extracellular matrix (ECM) homeostastic. Otherwise, curcumin inhibits both MMP-2 and TIMP-2 expression and enhances HSC apoptosis, thus inhibit fibrogenesis. Role of curcumin, MMP-2, and TIMP-2 in a fibrolysis process has not been widely studied. This study aimed to determine the correlation between curcumin administration and the decline of MMP-2 and TIMP-2 on rat model of liver fibrosis.Method: This is an experimental study done in male Wistar rats. There are 8 groups consist of 4 rats each. Both control and intervention group were exposed to CCl4 1 cc/kgBW intraperitoneally 2 times per week for 9 consecutive weeks to form F3 fibrosis. Negative control group was injected with normal saline. After CCl4 injection, control group was given curcumin solvent as placebo while intervention groups were given curcumin 200 mg/kgBW for 2, 5, and 9 weeks. Statistical analysis then conducted in the end of study. Results: MMP-2 and TIMP-2 were remarkably increased in positive control group, but found decreased in control group 5 and 9. There are remarkable decrease of MMP-2 and TIMP-2 serum level in intervention group 2, 5, and 9, but MMP-2 and TIMP-2 level was significantly lower in intervention group 2 compared to the control group.Conclusion: MMP-2 and TIMP-2 serum level were decreased after giving of curcumin for 2 weeks. The duration of curcumin administration correlated with decrease of TIMP-2 serum level but not correlated with MMP-2 serum level in rat model of liver fibrosis.

Comparing the Effects of Genistein, Silymarin, Lecithin on Improved Liver Necrosis Induced by Paracetamol Toxic Dose Administration in Rattus novergicus Wistar Strain Mustika, Syifa; Supriono, Supriono; Pratomo, Bogi; Achmad, Harijono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 1, April 2012
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Background: Paracetamol, a widely used antipyretic and analgesic drug has been known for its side effect of liver toxicity resulting from free radical formation leading to necrotic hepatocytes. Oral genistein may reduce lipid peroxidation and increase total antioxidant capacity in liver. The present study was aimed to compare the effects of administering genistein, silymarin and lecithin on improved necrotic hepatocytes in Wistar rats fed with toxic dose of paracetamol. Method: An experimental study was conducted at the Laboratory of Physiology and Anatomical Pathology, University of Brawijaya between May and September 2011. About 48 male rats were categorized into 4 groups. The first group was treated with 600 mg/kgBW of oral paracetamol. The other groups were treated with 600 mg/kgBW paracetamol and additional 2 mg/kgBW genistein, 50 mg/kgBW silymarin or 100 mg/kgBW lecithin. ALT, AST, bile acid, malondialdehyde (MDA) and glutation (GSH) levels were measured and centrilobular necrosis observed by histopathological examination. Data were analyzed statistically by ANOVA. Results: AST and ALT level were significantly lower in genistein group (p = 0.004 and p = 0.001). The lowest bile acid level was found in the lecithin group (p = 0.025); while lowest MDA level was found in silymarin group (p = 0.009). The highest GSH level was found in lecithin group (p = 0.001). The lowest percentage of centrilobular necrosis was found in genistein group (p = 0.001). Conclusion: Genistein, silymarin and lecithin supplementation improve liver necrosis induced by toxic dose of paracetamol. Among them, genistein is the most significant agent. Keywords: genistein, silymarin, lecithin, paracetamol, hepatotoxicity

Management of Autoimmune Hepatitis Supriono, Supriono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 1, April 2011
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Autoimmune hepatitis (AIH) is a necroinflammatory liver disease of unknown etiology. Although the pathogenetic mechanism of AIH is still unknown, an underlying genetic predisposition and the association of the disease with certain human leukocyte antigens (HLAs) have been suggested. The molecular mimicry has been proposed as a pathogenetic mechanism for AIH. The diagnosis of AIH is based on a constellation of clinical, serological, and histopathological findings. The International Autoimmune Hepatitis Group (IAIHG) proposed diagnosis criteria in 1993, which were revised in 1999. In 2008, the IAIHG decided to devise a simplified scoring system for wider applicability in routine clinical practice. Based on clinical and serological parameters, AIH cases have been categorized into three subtypes: type-1 AIH, type-2 AIH and type-3 AIH. The therapeutic guidelines of AIH include immunosuppressive agent with corticosteroid and usually in combination with azathioprine. Starting dose of prednisone monotherapy is 60 mg daily, which should be tapered slowly over a 1 week period to a maintenance dose of < 20 mg daily. The other regimen is used in combination with azathioprine, prednisone dose is started at 30 mg and tapered 10 to 5 mg every week until a maintenance dose of 10 mg is achieved. Azathioprine is given at the dose of 50 mg daily. In the very few patients that do not tolerate or have significant side effects to gold standard therapy, alternative immunosuppressive drugs should be given. Other powerful immunosuppressive drugs and molecular interventions are being developed based on recent insights into pathogenic pathways, emerging pharmacologic agents, and new technologies. Keywords: autoimmune hepatitis, pathogenesis, diagnosis, management

17 Year Old Female Patient with Systemic Lupus Erythematosus and Ulcerative Colitis Amelia, Rizky; Supriono, Supriono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 15, No 1 (2014): VOLUME 15, NUMBER 1, April 2014
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Gastrointestinal manifestations are common in systemic lupus erythematosus (SLE). Although the relationshipbetween SLE with ulcerative colitis (UC) rarely obtained, SLE patients with gastrointestinal manifestations shouldpreferably be evaluated for the possibility of an inflammatory bowel disease (IBD). UC prognosis associatedwith SLE is usually good, whereas by proper diagnosis and management, the clinical output and a good life expectancy of patients will be obtainedA young female, 17 years old, who had previously been diagnosed with SLE for 5 years, came with complaintsof abdominal pain and chronic diarrhea. From the results of colonoscopy and biopsy of the intestinal mucosawas noted that in accordance with UC. After receiving treatment for 6 days, she no longer obtained complaintsof abdominal pain and diarrhea. Keywords: systemic lupus erythematosus, gastrointestinal, ulcerative colitis, inflammatory bowel disease ABSTRAKManifestasi gastrointestinal merupakan hal yang sering terjadi pada lupus eritematosus sistemik (LES).Meskipun hubungan antara LES dengan kolitis ulseratif (KU) jarang didapatkan, sebaiknya pada pasien LESdengan manifestasi gastrointestinal dilakukan evaluasi untuk kemungkinan adanya suatu penyakit inflamasiusus besar. Prognosis UC terkait LES biasanya baik, dimana dengan diagnosis dan penatalaksanaan yang tepatakan didapatkan keluaran klinis dan harapan hidup yang baik pada pasien.Seorang perempuan muda berusia 17 tahun yang sebelumnya telah terdiagnosa LES selama 5 tahun, datangdengan keluhan nyeri perut dan diare kronik. Dari hasil pemeriksaan kolonoskopi dan biopsi mukosa ususdidapatkan gambaran yang sesuai dengan KU. Setelah mendapat terapi selama 6 hari, tidak didapatkan lagi keluhan nyeri perut dan diare.Kata kunci: lupus eritematosus sistemik, gastrointestinal, colitis ulseratif, penyakit inflamasi usus besar

Role of Phytopharmacy as Hepatoprotector in Chronic Hepatitis Herlianto, Budi; Mustika, Syifa; -, Supriono -; Pratomo, Bogi; Achmad, Harijono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 15, No 3 (2014): VOLUME 15, NUMBER 3, December 2014
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Background: Hepatitis is one of the health problems in Indonesia that require special treatment, in line with the increase of morbidity and mortality rate of this disease. Complications of hepatitis include liver cirrhosis and hepatocellular carcinoma. Indonesia, as a tropical country, has many medicinal plants that act as hepatoprotector, a substance that can protect liver from toxic agent. Use of medicinal plants is still considered as controversial treatment because there is still lack of studies. Medicinal plants with mix composition of phytopharmacy, such as: Curcuma xanthorrhiza, Arcangelesia flava, Nigella sativa, and Kleinhovia hospita show potency as hepatoprotector. The objective of this study is to analyse the function of phytopharmacy as hepatoprotector in chronic hepatitis.Method: This study is a clinical trial performed in the Gastroenterology Department and Outpatient Clinic in Saiful Anwar Hospital in May-June 2013. Chronic hepatitis B or C patients who have received antiviral therapy with > 3 fold increase of the threshold value of transaminase level, were included in this study. In this study, patients consumed phytopharmacy tablet 3 times per day. After 7 days of treatment, patients’ serum transaminase levels (ALT and AST) were re-assessed. Statistical analysis of before and after treatment data was performed using Wilcoxon test and the result was significant with p < 0.05.Results: From 10 patients, the average age was 50.3 years old. Sixty percent (60%) of them were male, with 50% suffered from chronic hepatitis B and the other 50% suffered from chronic hepatitis C. From this study, decrement of alanine transaminase (ALT) and aspartate transaminase (AST) after seven days of treatment were 45.06%, with p = 0.007 and 48.63%, with p = 0.007, respectivelyConclusion: Phytopharmacy supplementation in chronic hepatitis can decrease serum transaminase, however further study is needed. Keywords: chronic hepatitis, phytopharmacy, ALT, AST, hepatoprotector

Achalasia: A Review of Etiology, Pathophysiology, and Treatment Hedayanti, Nor; Supriono, Supriono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 1 (2016): VOLUME 17, NUMBER 1, April 2016
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Achalasia was a condition marked by peristaltic movement absent in lower esophageal sphincter and segment that hypertonic result in imperfect relaxation during food ingestion. Achalasia incidence did not differ between men and women, account for 1 in 100.000 people every year with prevalence of 10 in 100.000 people, unrelated specifically with ethnic, and has its highest incidence on 30-60 age group.Based on its etiology, it was divided into primary and secondary Achalasia, while based on its motility, it was into hypermotil, hypomotil, and amotil Achalasia. Until present, several therapeutic modalities were available to treat Achalasia, among them was pharmacology therapy, botulinum toxin injection via endoscopy, pneumatic dilatation, Heller myotomy surgery, and Per Oral Endoscopy Myotomy (POEM).

Successful Therapy in A 20 Years Old Male with Acute Pancreatitis Nugraheni, Asri; Supriono, Supriono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 1 (2017): VOLUME 18, NUMBER 1, April 2017
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Acute pancreatitis is an inflammation at pancreas that can be caused by biliary tract disease, alcohol and metabolic disorder. We presented a 20 years old male with acute pancreatitis, he was obese and had history of alcohol abuse came with severe abdominal pain. There is increasing amylase and lipase level, and his abdominal CT scan showed infiltrate peripancreatic, mesenteric, and left anterior pararenal space, hepatomegaly and mild ascites. Patient was given supportive treatment such as parenteral nutrition, analgetic, PPI, and also octreotide. With proper diagnosis and optimal treatment, patient was successfully treated without any complication.

A FEMALE WITH MALIGNANT ASCITES: A DIFFICULT CASE WITH CARCINOMA OF UNKNOWN PRIMARY Retno W, Dyah; -, Supriono
journal of internal medicine Vol. 13, No. 1 Januari 2012
Publisher : journal of internal medicine

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Malignant ascites is the abnormal accumulation of !uid in the peritoneal cavity associated with several intra-pelvicand intra-abdominal malignancies. Among the gynecologic malignancies, ovarian carcinoma predominates. Of thegastrointestinal malignancies, ascites can occur with advanced colon, pancreas, gastric carcinoma, and esophagealcarcinoma. Recent reports in the cytological literature suggest that 6% to 11% of malignant peritoneal effusions aredue to tumors of unknown origin.1 We reported a 62 years old female presenting adenocarcinoma ascites, which shownconfusing of site of primary origin from imaging examination. First ultrasound imaging showed mass on colon area, butre ultrasound of abdominal imaging showed the possibility of endometrium carcinoma. The CA 125 level was high (2.294u/ml). Open laparotomy showed milliar metastatic several nodule on omental, liver, and abdominal wall. There wasattachment of vesica urinaria, endometrium, colon, sigmoid, and rectum. All those result conclude this patient sufferedfrom malignant ascites of adenocarcinoma of unknown primary origin, with highly suggestive from malignant ascites ofadenocarcinoma of unknown primary origin, with highly suggestive from gynecologic malignancy that difcult to differwhether from ovarian cancer or endometrium cancer. Somehow, the epidemiology, pathophysiology, clinical presentationlead the diagnosis for ovarian cancer.

Insiden dan Gambaran Klinis Hepatitis Akibat Obat Anti Tuberkulosis di Rumah Sakit Umum Daerah Dr. Saiful Anwar Malang Rifai, Achmad; Herlianto, Budi; Mustika, Syifa; Pratomo, Bogi; Supriono, Supriono
Jurnal Kedokteran Brawijaya Vol 28, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Â Hepatitis akibat obat anti tuberkulosis (OAT) merupakan ancaman yang serius terhadap pengendalian penyakit tuberkulosis. Namun belum ada data yang representatif mengenai hal tersebut dalam suatu populasi. Penelitian ini bertujuan untuk memahami gambaran klinis dan mengevaluasi efek dari terapi obat anti tuberkulosis di Rumah Sakit Umum Daerah Dr. Saiful Anwar Malang pada tahun 2013. Penelitian ini merupakan penelitian deskriptif potong-lintang (cross sectional) yang melibatkan sebanyak 460 pasien tuberkulosis (TB) yang menerima directly observed treatment strategy (DOTS). Dari hasil penelitian diperoleh 25 pasien yang mengalami hepatitis akibat OAT dengan nilai insiden sebesar 5,4%. Gejala-gejala yang paling sering timbul adalah rasa mual dan muntah (48%). Terjadi hepatitis ringan (20%), sedang (48%), berat (4%), dan sengat berat (4%). Sebanyak 60% tanpa penyakit penyerta. Efek Hepatitis yang menyebabkan pemberhentian OAT sementara sebesar 56% kasus dan yang tetap meneruskan OAT sebesar 44% kasus, Â rata-rata durasi terapi hepatitis akibat Obat Anti Tuberkulosis adalah 18 hari. Hepatitis akibat OAT dapat mempengaruhi angka keberhasilan (outcome) terapi. Adanya insiden hepatitis akibat OAT dan besarnya populasi Hepatitis tersebut di Rumah Sakit Saiful Anwar menunjukkan bahwa mendeteksi efek negatif dari terapi OAT sangatlah penting.Kata Kunci: Anti-tuberculosis drug induced liver injury (ATLI), Obat Anti Tuberkulosis (OAT), tuberkulosis paru

PERBANDINGAN POTENSI TELBIVUDIN DAN TENOFOVIR DALAM MENURUNKAN SKOR ASPARTATE TRANSAMINASE TO PLATELET RATIO INDEX (APRI) PADA PASIEN HEPATITIS B Wibowo, Bogi Pratomo; Susanto, Edy; Supriono, Supriono; Mustika, Syifa
Majalah Kesehatan FKUB Vol 7, No 1 (2020): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Telbivudin dan tenofovir merupakan analog nukleosida untuk terapi hepatitis B dengan efektivitas tinggi meskipun telbivudin memiliki resistensi yang lebih tinggi daripada tenofovir. Telbivudin memiliki resistensi 2,3-5% pasien pada terapi tahun pertama dan 21,6% pasien pada terapi tahun kedua, sedangkan tenofovir dapat digunakan selama 3 tahun tanpa memunculkan resistensi. Hal ini menyebabkan tenofovir direkomendasikan sebagai terapi lini pertama oleh beberapa panduan. Namun demikian, bila terjadi resistensi tenofovir, sampai saat ini belum ada obat pengganti yang bisa digunakan. Tujuan pengobatan hepatitis B disamping menekan HBV DNA juga memperbaiki histologi jaringan hati. Oleh karena itu, perlu dilakukan penelitian untuk membandingkan potensi telbivudin dan tenofovir sebagai pilihan terapi hepatitis B kronis dengan melihat penurunan HBV DNA dan skor Aspartate Transaminasi to Platelet ratio Index (APRI).Â Penelitian analitik ini menggunakan pendekatan cross sectional. Data rekam medik dari pasien dengan terapi telbivudin dan tenofovir meliputi parameter skor APRI, yaitu kadar AST dan jumlah platelet, serta HBV DNA bulan 0 dan bulan 12. Data skor APRI dibandingkan menggunakan uji t independen dan dependen dengan nilai P < 0,05.Dari 145 pasien, 103 pasien mendapat terapi telbivudin, dan 42 pasien diterapi dengan tenofovir. Rerata penurunan skor APRI pada kelompok telbivudin adalah 1,17Â±0,17, sedangkan pada kelompok tenofovir 0,75Â±0,42. Pada kedua kelompok terjadi penurunan skor APRI sebelum dan sesudah terapi yang signifikan (p=0,00). Namun tidak didapatkan perbedaan yang bermakna antara kedua kelompok (p=0,28).Tidak terdapat perbedaan yang signifikan dalam potensi terapi antivirus antara telbivudin dan tenofovir dalam menurunkan skor APRI pasien hepatitis B kronis

Co-Authors A.A. Ketut Agung Cahyawan W Amanda C Wowor Asri Nugraheni Asri Nugraheni Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Budi Herlianto Budi Herlianto Dinda Oktaviani Dyah Retno W edy susanto Fiqih Faruz Handono Kalim Harijono Achmad Harijono Achmad Hedayanti, Nor Kriestian, Muhammad Mochammad Jalalul Marzuki Mudjiwijono Handaru Eko Muhammad Kriestian Nor Hedayanti Nugraheni, Asri Riyanto Rizky Amelia Syifa Mustika Syifa Mustika Syifa Mustika Syifa Mustika Wibowo, Bogi Pratomo

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