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Lupitaningrum, Dita Marina
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Pengaruh Penggunaan Antikolinergik Terhadap Gangguan Fungsi Kognitif Pada Pasien Geriatri di Lombok Tengah, Indonesia Lupitaningrum, Dita Marina; Rahmawati, Fita
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Geriatrics are more susceptible to the unwanted effects of drugs, such as potential cognitive impairment effects of anticholinergic drugs. This study aims to determine the effect of anticholinergic drug use on cognitive reduction in Central Lombok geriatric patients. This cross-sectional study was conducted by tracing a medical history and interview result using a Six-item Cognitive Impairment Tests (6-CIT) questionnaire to measure cognitive function. The sample size was 503 geriatric patients with 213 patients as users and 290 patients as non-users. Anticholinergic loads were determined in each patient using Anticholinergic Drug Scale (ADS). The data of the study were analyzed using Chi-square to see the effect of anticholinergic drug use on cognitive function reduction. A total of 168 patients (78.9%) used a single anticholinergic drug. Most of anticholinergic used were level 1 (95.8%). Patients who had a total anticholinergic load of 1 were 156 people (73.2%). In the user group, 191 patients (38%) experienced cognitive reduction. The most common disease experienced by drug user was circulatory system disease (50.9%) and the most widely used drug was furosemide (45.4%). Chi-square analysis showed that anticholinergic drug had significant effect on geriatrics impairment of cognitive function (OR 2.361; CI95% 1.399-3.983; P=0.002). The use of anticholinergic drugs had an effect on cognitive reduction in geriatric patient.
Identification of Adverse Drug Reactions in Congestive Heart Failure Patients in a Tertiary Care Hospital, West Nusa Tenggara, Indonesia Lupitaningrum, Dita Marina; Ramdaniah, Putri; Yuliana, Depi
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Congestive Heart Failure (CHF) is a progressive health problem with high mortality and morbidity and has the potential to develop adverse drug reactions (ADRs). This study was conducted to determine the prevalence of potential ADRs, the types of drugs that cause ADRs, the types of ADRs, and the risk factors that affect the ADRs in CHF patients. Data were collected using medical record of hospitalized patient at the West Nusa Tenggara (NTB) Provincial Hospital, Indonesia, in 2017 to 2019. The assessment of the causality and severity of ADRs used the Naranjo algorithm and the Hartwig and Siegel scale. This study used 325 CHF patients’ data. Of 325 CHF patients, 223 patients (69%) were recorded as having ADRs with 446 total cases of ADRs, consisted of 4 (0.9%) highly probable, 187 (41.9%) probable, and 255 (57.2%) possible. The drugs that cause ADRs with a highly probable status are bisoprolol and ramipril. The most ADRs categories were level 1 (76.0%), followed by level 2 (17.3%), level 3 (6.5%), and level 4A (0.2%). The most affected organ systems were the muscles, joints, and nervous system (n=136, 37.7%), followed by renal, and gastrointestinal system. No association between ADRs with several risk factors, such as gender, age, and comorbidities. The prevalence of ADRs in CHF patients in this study was 69%, with the highly probable category in causing ADRs were bisoprolol and ramipril. ADRs that mostly occurred were in the mild category. ADRs monitoring in CHF patients is especially important to achieve optimal therapeutic results.
Co-Authors Fita Rahmawati Ramdaniah, Putri Yuliana, Depi