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All Journal The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science
Gatot Nyarumenteng Adhipurnawan Winarno
Departemen Obstetri Dan Ginekologi, Fakultas Kedokteran, Universitas Padjadjaran, Rumah Sakit Hasan Sadikin, Bandung
Biochemistry, Genetics & Molecular Biology Health Professions Public Health

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Phylogenetic Analysis of Human Papillomavirus 16 and 52 L1 Gene from Cervical Cancer in Bandung, Indonesia Mutia Latief; Ika Agus Rini; Gita Widya Pradini; Gatot Nyarumenteng Adhipurnawan Winarno; Edhyana Sahiratmadja; Herman Susanto
The Indonesian Biomedical Journal Vol 10, No 1 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i1.296

Abstract

BACKGROUND: Chronic infection with high-risk type of human papillomavirus (HPV) can cause cervical cancer. Previous studies showed that multiple infections of HPV are found in cervical cancer caused by multiple HPV infections and the most common are HPV-16 and HPV-52. The origin of HPV-16 circulating in Indonesia varies. The purpose of this study was to explore the origin of multiple infections of HPV-52 and HPV-16 in cervical cancer by using a phylogenetic tree.METHODS: During July-November 2010, 100 women were diagnosed with cervical cancer in the Department of Obstetrics and Gynecology, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Only 96 patients were involved in this study. Ninety-six samples of HPV deoxyribonucleic acid (DNA) were isolated from biopsied tissue of cervical cancer. Multiple infections of HPV genotypes HPV-16 and HPV-52 were confirmed by using the linear assay for HPV genotyping test. Afterward,HPV-52L1 gene was amplified by using self-designed primer. L1 gene was also sequenced and analyzed using phylogenetic program (MEGA6.06).RESULTS: The result of phylogenetic tree construction showed that isolated HPV-52 originated from multiple infections of HPV-16 and HPV-52 from cervical cancer patients in Bandung were in a subgroup with isolates originating from EU077219 Canada (America) and KT799980 southwest China (Asia). Isolate HPV-16 in one subgroup with isolates originating from KU951191.1 (Southwest China).CONCLUSION: L1 gene sequence from multiple infections isolated from HPV-16 and HPV-52 from cervical cancer patients in Bandung refers to the variation of L1 gene reported from Canada and southwest China. This proves that Indonesia’s HPV clusters are located in the strains found in America and Asia.KEYWORDS: multiple infections, HPV-16, HPV-52, L1 gene, phylogenetic
Profil Klinikopatologi Pasien Tumor Trofoblas Gestasional yang Dilakukan Operasi di RSUP DR. Hasan Sadikin Bandung Tahun 2017-2020 Aviscena Fahmi Ali; Dodi Suardi; Hermin Aminah Usman; Gatot Nyarumenteng Adhipurnawan Winarno; Andi Kurniadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 2 September 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n2.381

Abstract

Tujuan: Mengetahui proporsi klinis dan histopatologi pasien tumor trofoblas gestasional yang dilakukan operasiMetode: Penelitian ini menggunakan desain studi deskriptif, dengan pengambilan data menggunakan total sampling. Kriteria inklusi adalah Pasien tumor trofoblas gestasional yang dilakukan operasi dengan data lengkap.Hasil: Total 27 kasus, didapatkan bahwa pasien tumor trofoblas gestasional yang dilakukan operasi sebagian besar memiliki kategori usia ≥40 tahun (59,26%), paritas multipara (66,67%), kehamilan sebelumnya mola (66,67%), interval dengan kehamilan sebelumnya >12 bulan (55,56%), kadar β-hCG sebelum operasi 103 -<104 mIU/ml (40,74%), ukuran tumor terbesar ≥5 cm (88,89%), lokasi metastasis tidak ada (74,07%), jumlah metastasis 0 (74,07%), kegagalan kemoterapi agen multipel (74,07%), jenis operasi histerektomi (96,30%), kadar β-hCG setelah operasi <103 mIU/ml (77,78%),  dan gambaran histopatologi koriokarsinoma (88,89%). Diskusi: Penelitian ini didapatkan bahwa seluruh pasien tumor trofoblas gestasional yang dilakukan operasi memiliki skor FIGO/WHO ≥7 yang berarti berisiko tinggi.Kesimpulan: Kasus-kasus tumor trofoblas gestasional yang dilakukan operasi pada penelitian ini sebagian besar memberikan profil klinis berupa multipara, jenis kehamilan sebelumnya mola, dan kegagalan kemoterapi agen multipel dengan jenis histopatologi koriokarsinoma.Profile Clicopathological of Gestational Trophoblastic Neoplasia Patients Who Underwent Surgery at Dr. Hasan Sadikin General Hospital Bandung in 2017–2020AbstractObjective: Knowing the clinical and histopathological proportion of gestational trophoblastic neoplasia patients who underwent surgery.Methods: This study uses a descriptive study design and the data collection using total sampling. The inclusion criteria gestational trophoblastic neoplasia patients who underwent surgery with complete data.Result: : A total of 27 cases, it was found that the most GTN patients who underwent surgery had an age category of 40 years (59.26%), multiparity (66.67%), previous molar pregnancies (66.67%), intervals with previous pregnancies >12 months (55.56%), β-hCG levels before surgery 103 -<104 mIU/ml (40.74%), the largest tumour size 5 cm (88.89%), no metastatic site (74.07 %), failure of multiple agent chemotherapy (74,07%), hysterectomy surgery (96.30%), β-hCG level after surgery <103 mIU/ml (77.78% ), and histopathological features of choriocarcinoma (88.89%).Discussion: In this study, it was found that all gestational trophoblastic neoplasia patients who underwent surgery had a FIGO/WHO score ≥7 which means high risk.Conclusion: The gestational trophoblastic neoplasia cases that underwent surgery in this study presented a clinical profile of multiparity, previous molar pregnancy, and failure of multiple agent chemotherapy with histopathological type of choriocarcinoma.Key words: Profile, gestational trophoblastic neoplasia, operation
Profil dan Karakteristik Penderita Tumor Trofoblas Gestasional di RSUP Dr. Hasan Sadikin Periode 2021 Muhamad Bagja Ramadhan; Siti Salima; Andi Kurniadi; Gatot Nyarumenteng Adhipurnawan Winarno; Ali Budi Harsono
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 2 September 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n2.380

Abstract

Tujuan: Tumor trofoblas gestasional (TTG) adalah suatu bentuk keganasan ginekologi pada hidatidosa yang diakibatkan oleh adanya abnormalitas proliferasi sel trofoblas. Insidensi TTG di negara Asia Tenggara ialah 9,2:40000 kehamilan. Beberapa faktor yang mempengaruhi perkembangan TTG diantaranya ialah riwayat kehamilan, usia dan kadar b-hcg. Namun hingga saat ini profil pasien TTG masih terbatas, oleh karenanya penelitian ini bertujuan menganalisis profil dan karakteristik pasien TTG di RSUP Dr. Hasan Sadikin Bandung.Metode: Metode penelitian ini ialah deskriptif kuantitatif, dengan menggunakan data sekunder yang berasal dari rekam medis pasien. Seluruh pasien yang didiagnosis TTG pada periode 2021 menjadi sampel pada penelitian ini. Variabel penelitian ini ialah status sosiodemografi, faktor risiko, gambaran klinis, dan gambaran terapi.Hasil: Jumlah sampel pada penelitian ini ialah 66 pasien. Sebanyak 53,03% pasien berusia 20-35 tahun. Sebanyak 55 pasien datang dalam kondisi stadium I (83,33%) sedangkan berdasarkan skoring FIGO sebanyak 42 pasien (63,63%) merupakan pasien dengan risiko rendah. Metastasis paru terjadi pada 7 pasien (20,61%). Kesimpulan: Mayoritas pasien TTG berusia 20-35 tahun dan tidak bekerja. Secara gambaran klinis; stadium I dan risiko rendah sering ditemukan. Kemoterapi dominan dipilih, serta multi-agent lebih sering digunakan.Profile and Characteristics GTN cases in Hasan Sadikin General Hospital in 2021 Gestational Trophoblastic NeoplasmaAbstractObjective: Gestational trophoblastic tumor (TTG) is a form of hydatidiform gynecologic malignancy caused by abnormal trophoblast cell proliferation. The incidence of TTG in Southeast Asian countries is 9.2:40000 pregnancies. Several factors that influence the development of TTG include a history of pregnancy, age and levels of b-hCG. However, until now the profile of TTG patients is still limited, therefore this study aims to analyze the profiles of TTG patients at Dr. Hasan Sadikin Bandung.Methods: This research method is descriptive quantitative, using secondary data derived from the patient's medical record. All patients diagnosed with TTG in the period 2021 were sampled in this study. The variables of this study were sociodemographic status, risk factors, clinical features, and therapeutic features.Results: The number of samples in this study was 66 patients. A total of 53.03% of patients aged 20-35 years. A total of 55 patients came in stage I condition (83.33%) while based on FIGO scoring 42 patients (63.63%) were low risk patients. Pulmonary metastases occurred in 7 patients (20.61%). Conclusion: The majority of TTG patients are aged 20-35 years and do not work. In the clinical picture; stage I and low risk are common. Predominant chemotherapy is chosen, and multi-agent is used more often.Key words: Gestational Trophoblastic Neoplasia, Patient Profile, Hydatidiform mole, Gynecological Malignancy
Co-Authors Andi Kurniadi, Andi Aviscena Fahmi Ali Dodi Suardi Edhyana Sahiratmadja Gita Widya Pradini HARSONO, ALI BUDI Herman Susanto Hermin Aminah Usman Ika Agus Rini Muhamad Bagja Ramadhan Mutia Latief Siti Salima