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All Journal JURNAL PENELITIAN FARMASI & HERBAL PharmaCine : Journal of Pharmacy, Medical and Health Science
Audi Ichsani Aribowo
Universitas Singaperbangsa Karawang
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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ANALISIS CEMARAN LOGAM BERAT TIMBAL (Pb) PADA MAKANAN DAN MINUMAN : STUDI LITERATUR Audi Ichsani Aribowo; Bunga Nur Annisa; Nena Vauziah Sary; Lina Nurfadhila; Marsah Rahmawati Utami
Jurnal Penelitian Farmasi & Herbal Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i1.1038

Abstract

Heavy metals are defined as the transition elements that have a high atomic mass, are toxic, and cannot be broken down by living organisms. Metal Lead (Pb) is one of the heavy metals which are widely distributed in the environment. Heavy metal lead is one of the causes of serious health problems because it can cause disturbances to the human body. Therefore, the aim of this literature review is to present an illustration and up-to-date data on the analytical methods used for food and beverages contaminated with lead heavy metal (Pb). The methodology of this research is a literature review study from several databases such as Science Direct, Pubmed, and Google Scholar with a limitation of publication in the last 10 years. The results of a literature review from the analysis of Pb metal contamination in food and beverages, there are several techniques that can be utilized to analyze and various factors that cause the amount of lead (Pb) levels such as the atomic absorption spectrophotometer (AAS) method.
Kandidat Obat Baru Dan Target Kerja Obat Penyakit Systemic Lupus Erythematosus : Tinjauan Pustaka Audi Ichsani Aribowo; Lestari Mahardika Urbaningrum; Cantika Nurul Sa'adah; Bunga Nur Annisa; Nena Vauziah Sary; Christina Febiola Lubis; Lina Nurfadhila; Marsah Rahmawati Utami
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol 3 No 2 (2022): PharmaCine : Journal of Pharmacy, Medical and Health Science
Publisher : Program Studi Farmasi Fakultas Ilmu Kesehatan Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v3i2.7973

Abstract

Systemic lupus erythematosus (SLE) ialah penyakit dengan kerusakan pada sistem kekebalan tubuh, terutama dalam imunitas seluler dan humoral. SLE terjadi pada individu dengan predisposisi genetik, terutama pada gen HLA yang dipicu oleh faktor lingkungan. Pada kebanyakan kasus, SLE muncul akibat efek dari banyak varian gen. Ada banyak golongan obat yang biasa digunakan untuk pengobatan SLE seperti kortikosteroid, imunosupresan, NSAID, atau antibodi monoklonal spesifik yang diarahkan terhadap reseptor permukaan sel atau sitokin Tujuan dari tinjauan pustaka ini adalah untuk memberikan gambaran dan informasi terkini tentang kandidat obat baru dan target kerja obat penyakit lupus. Metode yang digunakan berupa tinjauan pustaka dari Google Scholar, Science Direct, dan PubMed dengan kriteria inklusi dan eksklusi. Hasil target kerja obat tersebut melalui tiga jenis penelitian berupa in vivo, in vitro, dan in silico. Berdasarkan tinjauan pustaka yang sudah dilakukan, terdapat beberapa target kerja obat pada penyakit lupus/SLE yaitu reseptor PI3Kδ, Enzim NF-κB inducing kinase, IFN-γ, IL-3, TNF-α, TP53, VEGFA, IL6, CD4, CCR1, JAK2, XRCC5, XRCC6, RB1, MYC, TP53, IL-1 alpha, IL-5, IL-6, IL-17, Limfotoxin-alpha, IL-21, TLR7, TLR9, CAPS3, STAT3, STAT1, IFNα, FcγR2A, CD22, CD20. Lalu untuk hasil beberapa kandidat obat baru terdapat pada ekstrak daun Bryophyllum pinnatum, curcumin, Langchuangding, Hedyotis diffusa Willd, dan BIIB059. Semua target atau kandidat senyawa pengobatan lupus yang diteliti memiliki hasil yang baik untuk pengobatan lupus.
Co-Authors Bunga Nur Annisa Cantika Nurul Sa'adah Christina Febiola Lubis Lestari Mahardika Urbaningrum Lina Nurfadhila Marsah Rahmawati Utami Nena Vauziah Sary