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All Journal Jurnal EduHealth PharmaCine : Journal of Pharmacy, Medical and Health Science
Christina Febiola Lubis
Universitas Singaperbangsa Karawang
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Article Review: Analysis Of Artificial Sweetness In Food And Beverages: English Wildani Zakiyah; Cantika Nurul Sa'adah; Fajar Prasetyo; Christina Febiola Lubis; Lina Nurfadhila; Marsah Rahmawati Utami
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.02 KB)

Abstract

Artificial sweeteners are substances added to food and beverages with the aim of giving a sweet taste, having no nutritional value. The types of artificial sweeteners allowed by the Minister of Health are Cyclamate, Saccharin, Aspartame and Sorbitol. The method used in this paper is a literature review study. The total journals used in this article review are 14 journals. In several studies, the levels of artificial sweeteners contained in related foods are still within the limits permitted by the government, but in some studies there are still foods whose levels of artificial sweeteners exceed the permitted limits.
Standardization of Anthocyanin Compounds in Plants in Indonesia: Literature Review Annastya Eka Agustin; Vriezka Mierza; Bunga Nur Annisa; Cantika Nurul Sa’adah; Fajar Prasetyo; Christina Febiola Lubis
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.134 KB)

Abstract

Anthocyanins are secondary metabolites belonging to the flavonoid group which act as pigments or coloring agents in plants that give red, blue and purple colors to flowers, fruits and vegetables. Anthocyanins have several pharmacological activities such as antioxidants, anti-carcinogenic, preventing impaired liver function, anti-hypertensive, and anti-diabetic. The anthocyanin structure consists of an aglycone form which is sterified by several sugar groups (glycones) and acyl groups in several anthocyanin compounds. In an effort to maintain the standard of a drug made from natural ingredients, the process of standardization of active compounds can be carried out to guarantee and maintain safety, quality uniformity and efficacy. This review was conducted to identify the anthocyanins contained in an extract by means of thin layer chromatography (TLC), UV-Vis spectrophotometer, thin layer chromatography-densitometry, and high performance liquid chromatography (HPLC). The research methodology used is in the form of literature review with reference sources related to the review topic obtained from various sources, such as Pubmed, Science Direct, and Google Scholar.
Kandidat Obat Baru Dan Target Kerja Obat Penyakit Systemic Lupus Erythematosus : Tinjauan Pustaka Audi Ichsani Aribowo; Lestari Mahardika Urbaningrum; Cantika Nurul Sa'adah; Bunga Nur Annisa; Nena Vauziah Sary; Christina Febiola Lubis; Lina Nurfadhila; Marsah Rahmawati Utami
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol 3 No 2 (2022): PharmaCine : Journal of Pharmacy, Medical and Health Science
Publisher : Program Studi Farmasi Fakultas Ilmu Kesehatan Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v3i2.7973

Abstract

Systemic lupus erythematosus (SLE) ialah penyakit dengan kerusakan pada sistem kekebalan tubuh, terutama dalam imunitas seluler dan humoral. SLE terjadi pada individu dengan predisposisi genetik, terutama pada gen HLA yang dipicu oleh faktor lingkungan. Pada kebanyakan kasus, SLE muncul akibat efek dari banyak varian gen. Ada banyak golongan obat yang biasa digunakan untuk pengobatan SLE seperti kortikosteroid, imunosupresan, NSAID, atau antibodi monoklonal spesifik yang diarahkan terhadap reseptor permukaan sel atau sitokin Tujuan dari tinjauan pustaka ini adalah untuk memberikan gambaran dan informasi terkini tentang kandidat obat baru dan target kerja obat penyakit lupus. Metode yang digunakan berupa tinjauan pustaka dari Google Scholar, Science Direct, dan PubMed dengan kriteria inklusi dan eksklusi. Hasil target kerja obat tersebut melalui tiga jenis penelitian berupa in vivo, in vitro, dan in silico. Berdasarkan tinjauan pustaka yang sudah dilakukan, terdapat beberapa target kerja obat pada penyakit lupus/SLE yaitu reseptor PI3Kδ, Enzim NF-κB inducing kinase, IFN-γ, IL-3, TNF-α, TP53, VEGFA, IL6, CD4, CCR1, JAK2, XRCC5, XRCC6, RB1, MYC, TP53, IL-1 alpha, IL-5, IL-6, IL-17, Limfotoxin-alpha, IL-21, TLR7, TLR9, CAPS3, STAT3, STAT1, IFNα, FcγR2A, CD22, CD20. Lalu untuk hasil beberapa kandidat obat baru terdapat pada ekstrak daun Bryophyllum pinnatum, curcumin, Langchuangding, Hedyotis diffusa Willd, dan BIIB059. Semua target atau kandidat senyawa pengobatan lupus yang diteliti memiliki hasil yang baik untuk pengobatan lupus.
Co-Authors Annastya Eka Agustin Audi Ichsani Aribowo Bunga Nur Annisa Cantika Nurul Sa'adah Cantika Nurul Sa’adah Fajar Prasetyo Lestari Mahardika Urbaningrum Lina Nurfadhila Lina Nurfadhila Marsah Rahmawati Utami Nena Vauziah Sary Vriezka Mierza Wildani Zakiyah