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Effectiveness of Open Worksheet Based on Problems on Skills of Science Process and Creative Thinking of Junior High School Students Yusi Ardiyanti; Marsah Rahmawati Utami
Jurnal Sekolah Dasar Vol 5 No 2 (2020): Jurnal Sekolah Dasar
Publisher : LPPM Universitas Buana Perjungan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jurnalsekolahdasar.v4i2.995

Abstract

The quality of education is a direct consequence of a change and development of learning at this time. To optimize learning that requires students to have science process skills and creative thinking (in accordance with 21st-century demands) it is necessary to develop more varied learning media. One way is to develop a problem-based open Worksheet that allows students to add information about a material systematically with reference to problem-based learning by covering several stages, including orienting students to problems, organizing students to learn, guiding individual investigations or group, develop and present data, and analyze and evaluate work results. That is expected to improve the skills mentioned above.
ANALISIS AKTIVITAS TOKSISITAS BEBERAPA MINYAK ATSIRI DENGAN METODE BRINE SHRIMP LETHALITY TEST Marsah Rahmawati Utami; Yusi Ardiyanti
Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Vol 3 No 1 (2019): Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan)
Publisher : Sekolah Tinggi Ilmu Kesehatan Holistik

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (619.913 KB) | DOI: 10.51873/jhhs.v3i1.34

Abstract

Background: Essential oils are commonly used as raw materials for fragrance oils, medicines and cosmetics. In the pharmaceutical field, essential oils are used as antibacterial, anti-pain and anti-infection. This pharmacological effect is related to secondary metabolites contained in the essential oil. The effectiveness of the active components of secondary metabolites as a drug can be determined by toxicity analysis as a preliminary test. Toxicity analysis that is commonly used is the Brine Shrimp Lethality Test (BSLT). This test illustrates the level of toxicity of extracts against Artemia salina larvae. The results of this test can be used as a preliminary test to identify broader plant bioactivity. Objective: The aim of this study was to analyze the toxicity activities of basil leaf essential oils, galangal rhizome and red betel leaf and their secondary metabolite content. Method: Essential oils were isolated by the steam distillation method, their toxicity activity was tested by the BSLT method, and the contents of the chemical compounds were analyzed by GC-MS. Conclusion: Brine Shrimp Lethality Test results showed that the essential oils of the leaves of the kemanggi, galangal rhizome, and red betel have a level of toxicity with LC50 respectively 57.21 ppm, 110.01 ppm, 360.51 ppm. Based on the results of GC-MS analysis, the main components of the kemanggi leaf essentialoil are lemonal and beta citral, the main components of galangal rhizome essential oil are 2,6-dimethylphenyl borate an 1,8-cineol, while the main components of the red betel essential oil are sabinena and beta mircena.
PENGARUH PROBLEM-BASED LEARNING TERHADAP PENGUASAAN KONSEP DAN KETERAMPILAN BERPIKIR KREATIF SISWA SMK PADA MATERI KARBOHIDRAT Yusi Ardiyanti; Marsah Rahmawati Utami; Dewi Ratnasari
Satya Widya Vol 36 No 2 (2020)
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Kristen Satya Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24246/j.sw.2020.v36.i2.p81-87

Abstract

Penelitian bertujuan untuk mengetahui bagaimana pengaruh pendekatan problem-based learning pada peningkatan penguasaan konsep dan keterampilan berpikir kreatif siswa SMK pada materi karbohidrat. Penelitian ini merupakan penelitian kuasi ekperimen, dengan desain kelompok kontrol non-ekuivalen yang melibatkan dua kelompok. kelas eksperimen yang mendapat pembelajaran dengan pendekatan Problem-Based Learning dan kelas kontrol yang mendapat pembelajaran menggunakan pendekatan pembelajaran konvensional. Instrumen yang digunakan pada penelitian ini adalah pretest, posttest dan angket, innstrumen pretest posttest berupa 20 soal pilihan ganda (untuk menguji kemampuan penguasaan konsep) dan 4 soal essay(untuk menguji keterampilan berpikir kreatif). Sebelum melakukan pengujian hipotesis maka data penelitian harus memenuhi uji prasyarat yang meliputi uji normalitas (uji Shapiro-Wilk), uji homogenitas varians (Lavene test), uji kesamaaan kemampuan awal siswa (uji t), uji hipotesis penelitian pada posttest dan N-gain dilakukan uji t (parametric) atau Mann Whetney (non parametric). Berdasarkan analisis data diperoleh N-Gain keterampilan berpikir kreatif siswa kelas yang mendapatkan pembelajaran dengan PBL lebih tinggi dibandingkan kelas kontrol yaitu sebesar 0,42 (kategori sedang untuk kelas eksperimen). Namun N-Gain kemampuan penguasaan konsep siswa kelas kontrol lebih tinggi dibandingkan kelas ekperimen yaitu sebesar 0,39 (kategori sedang untuk kelas kontrol)
Analisis Fitokimia Dan Toksisitas Ekstrak Etanol Daun, Kulit Batang, Akar Tanaman Simpur (Dillenia indica L) Dengan Metode Brine Shrimp Lethality Test (BSLT) Marsah Rahmawati Utami; Ratna Dewi Anjani
Media Farmasi XXX Vol 16, No 2 (2020): MEDIA FARMASI
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v16i2.1746

Abstract

The elephant apple (Dillenia indica) is a local plant with medicinal potential. Several studies have stated that its fruit and leaf extracts have pharmacological effects, which includes antioxidant, antimicrobial and antidiabetic activity. This research aims to determine the phytochemical content and toxicity activity of the elephant apple (Dillenia indica L) leaf, bark and root extracts. The method used includes plant determination, phytochemical test, extraction, and toxicity test using the Brine Shrimp Lethality Test (BSLT) method. The data analysis technique for the toxicity test was carried out by determining the LC50 value (Lethality Concentration 50) using probit analysis. The results showed that the leaf and stem extracts contained alkaloid, flavonoid, tannin, saponin, terpenoid and steroid class compounds, while the root extract contained alkaloids, flavonoids and tannins. The LC50 extracts of the roots, bark and leaves were 27.10 ppm, 208.26 ppm and 13.57 ppm, respectively. Based on these results, it was concluded that the three extracts have toxicity activity and have the bioactivity potential as an anticancer.Keywords: Dillenia indica, BSLT, LC50, toxicity Simpur (Dillenia indica) merupakan salah satu tanaman lokal yang berpotensi sebagai obat. Beberapa penelitian menyebutkan bahwa ekstrak buah dan daun simpur, memiliki efek farmakologis diantaranya adalah  aktivitas antioksidan, antimikroba dan antidiabetes . Penelitian ini bertujuan untuk mengetahui kandungan fitokimia dan aktivitas toksisitas ekstrak daun, kulit batang, dan akar  simpur ( Dillenia indica L ). Metode penelitian yang dilakukan meliputi determinasi tanaman,uji fitokimia, ekstraksi, dan uji toksisitas dengan metode Brine Shrimp Lethality Test(BSLT). Teknik analisis data untuk uji toksisitas dilakukan dengan menentukan nilai LC50 ( Lethality Concentration 50) dengan analisis probit.  Hasil penelitian menunjukan bahwa ekstrak daun dan batang  mengandung senyawa golongan alkaloid, flavonoid, tannin, saponin, terpenoid dan steroid, sedangkan ekstrak akar mengandung  alkaloid, flavonoid dan tannin. LC50 ekstrak akar, kulit batang, dan daun secara berturut-turut adalah 27,10 ppm, 208,26  ppm dan 13,57 ppm. Berdasarkan hasil tersebut dapat disimpulkan bahwa ketiga ekstrak memiliki aktivitas toksisitas dan berpotensi memiliki bioaktivitas sebagai antikanker.Kata Kunci: Dillenia indica, BSLT, LC50, toksisitas
IDENTIFIKASI MISKONSEPSI SISWA PADA MATERI SISTEM REPRODUKSI Yusi Ardiyanti; Marsah Rahmawati Utami
Biosfer : Jurnal Biologi dan Pendidikan Biologi Vol 2 No 2 (2017): Biosfer: Jurnal Biologi dan Pendidikan Biologi
Publisher : Program Studi Pendidikan Biologi, FKIP Unpas,

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.875 KB) | DOI: 10.23969/biosfer.v2i2.574

Abstract

Understanding the concept of biology is necessary in the integration of nature and technology in everyday life, if the concept of understanding is strong, students can develop and understand higher concepts. But sometimes students have a different understanding of concepts with scientifically accepted concepts and that will lead to misconceptions. The purpose of this study is to determine whether there is misconception in students and sub-concept what most misconception in reproduction system material. To calculate the misconception level of the Certainty of Response Index (CRI) method with the subjects of the study were students of class XI SMA 2 Cikampek. The data can show students misconception for some sub-concepts. The highest misconceptions exist in the menstrual subconses, which is 32.5% while the lowest is in the 10% gamete formation subconsep. This is because students interpret their own understanding of a material based on a text book that is read and an explanation from the teacher.
EVALUASI PENYELENGGARAAN PENDIDIKAN DI PERGURUAN TINGGI: RELEVANSI BIDANG PEKERJAAN DENGAN PROGRAM STUDI Karunia Eka Lestari; Marsah Rahmawati Utami; Mokhammad Ridwan Yudhanegara
JUDIKA (JURNAL PENDIDIKAN UNSIKA) Vol 9 No 2 (2021): JUDIKA (JURNAL PENDDIDIKAN UNSIKA)
Publisher : Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This qualitative descriptive study aims to evaluate the implementation of education in higher education by observing the relevance of the graduate's occupation with the Study Program. The data analyzed is tracer study data obtained from the Career Development Division at one of the leading higher education in Indonesia. The data records 2561 profiles of graduates from the 2010 batch, and 1566 of them have jobs in various fields, while the other 995 graduates are unemployment or continuing their studies. Data analyzed by performing correspondence analysis. The output of this method produces a graphical display of the data in a correspondence plot. The plot displays information about the association's structure between the relevance of the graduate's occupation and the Study Program. The result shows that 69.97% of graduates have jobs that are relevant to the field of study, with the most corporation area (16%), specifically in the industry field (category C), and the most job description (22%) in the research and development division. The results of this study, in general, can be used as recommendations in evaluating the implementation of education in higher education, especially in managing career development programs for graduates.
Isolasi Minyak Atsiri Daun Sirih Merah (Piper cf. fragile. Benth) Marsah Rahmawati Utami
Jurnal Agrotek Indonesia (Indonesian Journal of Agrotech) Vol 2 No 1 (2017): Jurnal Agrotek Indonesia (Indonesian Journal of Agrotech)
Publisher : Faculty of Agriculture University of Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.785 KB) | DOI: 10.33661/jai.v2i1.719

Abstract

Piper cf. fragile (sirih merah) adalah salah satu tanaman herbal yang mengandung minyak atsiri dan telahdigunakan sebagai bahan obat secara tradisional di Indonesia.Tujuan dari penelitian ini adalah untuk mengisolasi,memfraksionasi dan mengidentifikasi komponen-komponen yang terkandung dalam minyak atsiri sirih merah.Penelitian dilakukan pada tahun 2011 di Institut Pertanian bogor. Penelitian ini dilakukan empat tahap, yaitupengumpulan bahan, isolasi minyak atsiri daun sirih merah dengan destilasi air, fraksinasi minyak atsiri dengankromatografi kolom dan analisis komponen dengan GC-MS.Hasil penelitian menunjukan bahwa isolasi minyak atsiriyang diperoleh sebanyak 0,24 % (v/b). Minyak atsiridifraksinasi dengan kromatografi kolom (heksana-kloroformmetanolsebagai fasa gerak)menghasilkan 4 fraksi. Hasil analisis GC-MS dari ekstrak teridentifikasi mengandungkomponen utama : Alpha tuhyena, sabinena, beta mirsen, alpha terpinena beta felandrena, gamma terpinena, alphaterpirolena, linalool, 4-terpineol, trans kariofilena, germakrena D, alpha kopaena. Komponen utama fraksi 1 adalahsabinena (38,27%) dan beta mircena (22,94%) , pada fraksi 2 mengandung komponen utama linalool (20,36%)dan 4-terpineol (31,67%). Dari hasilnyadapat disimpulkan bahwa minyak atsiri sirih merah mengandungkomponen utamamonoterpene (seperti sabinen, mircen,Alpha tuhyen, Alpha terpinen, Gamma terpinen) dan sesquiterpen (seperti transcariofillen and germacrenD)Kata kunci: isolasi, fraksinasi, destilasi air, Piper cf. fragile, minyak atsiri.
Aktivitas Antioksidan Kombinasi Ekstrak Daun Sirsak (Annona muricata L.) dan Ekstrak Daun Pepaya (Carica papaya L.) dengan Metode DPPH Fika Setra Rikantara; Marsah Rahmawati Utami; Ahsanal Kasasiah
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 2 (2022): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i2.8819

Abstract

ABSTRAKPada era modern ini pola hidup masyarakat telah mengalami perubahan yang berdampak buruk pada kesehatan, selain itu kondisi lingkungan yang memburuk seperti banyaknya polusi juga akan menyebabkan terbentuknya radikal bebas. Radikal bebas dapat dicegah oleh senyawa antioksidan. Salah satu sumber antioksidan alami yaitu sirsak (Annona muricata L.) dan pepaya (Carica papaya L). Penelitian ini dilakukan untuk mendapatkan nilai aktivitas antioksidan kombinasi daun sirsak dan daun pepaya. Sampel daun sirsak dan daun pepaya dikombinasi dengan variasi perbandingan  ((1:0) (0:1) (1:1) (1:2) dan (2:1)) dengan konsentrasi 20, 40, 60, 80 dan 100 μg/mL sedangkan vitamin C sebagai pembanding dibuat dengan konsentrasi 2, 4, 6, 8, dan 10 μg/mL. Tiap seri konsentrasi ditambahkan DPPH 40 ppm dan diinkubasi selama 30 menit, lalu diukur absorbansinya menggunakan Spektrofotometri Visibel pada panjang gelombang 517 nm. Nilai IC50 yang didapatkan untuk ekstrak daun sirsak (1:0) sebesar 11,484 μg/mL, nilai IC50 ekstrak daun pepaya (0:1) sebesar 53,668 μg/mL, nilai kombinasi ekstrak daun sirsak (1:1) ekstrak daun pepaya sebesar 25,666 μg/mL, nilai IC50 kombinasi ekstrak daun sirsak (1:2) ekstrak daun pepaya sebesar 50,305 μg/mL, dan nilai IC50 kombinasi ekstrak daun sirsak (2:1) ekstrak daun pepaya sebesar 16,552 μg/mL sedangkan nilai IC50 vitamin C sebesar 3,365 μg/mL. Hasil penelitian untuk seri kombinasi meningkatkan aktivitas antioksidan dari ekstrak etanol daun pepaya namun akan menurunkan aktivitas antioksidan ekstrak daun sirsak. Kata kunci : Antioksidan; Daun Sirsak ; Daun Pepaya; DPPH; Spektrofotometri UV-Vis.ABSTRACTIn this modern era, people's lifestyles have undergone changes that have a negative impact on health, in addition to deteriorating environmental conditions such as the amount of pollution will also cause the formation of free radicals. Free radicals can be prevented by antioxidant compounds. One of the sources of natural antioxidants are soursop (Annona muricata L.) and papaya (Carica papaya L. This study was conducted to obtain the value of the antioxidant activity of the combination of soursop leaves and papaya leaves. Soursop leaf and papaya leaf samples were combined with various comparisons ((1:0). ) (0:1) (1:1) (1:2) and (2:1)) with concentrations of 20, 40, 60, 80 and 100 μg/mL while vitamin C as a comparison was made with concentrations of 2, 4, 6 , 8, and 10 μg/mL. Each concentration series was added with 40 μg/mL DPPH and incubated for 30 minutes, then the absorbance was measured using Visible Spectrophotometry at a wavelength of 517 nm. The IC50 value obtained for soursop leaf extract (1:0) was 11,484 g /mL, the IC50 value of papaya leaf extract (0:1) was 53,668 g/mL, the combination value of soursop leaf extract (1:1) papaya leaf extract was 25,666 μg/mL, the IC50 value of the combination of soursop leaf extract (1:2) extract papaya leaves of 50,305 μg/mL, and the IC50 value of the combination of soursop leaf extract (2:1) ext. papaya leaf shelf is 16,552 μg/mL while the IC50 value of vitamin C is 3,365 μg/mL. The results for the combination series increased the antioxidant activity of the ethanol extract of papaya leaves but decreased the antioxidant activity of the soursop leaf extract.Keywords : Antioxidant; Soursop leaves; Papaya leaves; DPPH; Spectrophotometry UV-Vis.
Perbandingan Aktivitas Antibakteri Ekstrak Etanol Biji Hijau dan Sangrai Kopi Robusta (Coffea canephora L.) Serta Kombinasinya Terhadap Bakteri Staphylococcus aureus Nabila Rubinadzari; Lely Sulfiani Saula; Marsah Rahmawati Utami
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 2 (2022): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i2.9393

Abstract

ABSTRAKStaphylococcus aureus merupakan bakteri dengan prevalensi tertinggi pada luka ulkus diabetikum yang dapat memperlambat proses penyembuhan luka. Hal ini kemudian diperparah dengan adanya resistensi terhadap berbagai antibiotik. Kopi dapat menjadi alternatif lain mengatasi resistensi antibiotik karena memiliki senyawa antibakteri, namun pemanggangan pada biji kopi akan menurunkan senyawa yang bertanggung jawab terhadap aktivitas antibakteri. Penelitian ini bertujuan untuk mengidentifikasi perbedaan aktivitas antibakteri ekstrak biji hijau dan sangrai kopi robusta (Coffea canephora L.) terhadap Staphylococcus aureus. Penelitian ini menggunakan desain post-test only control group dengan metode agar difusi cakram (Kirby-bauer). Sampel dibagi menjadi 13 kelompok, yaitu kontrol positif clindamycin, kontrol negatif aquades steril, kelompok perlakuan ekstrak biji hijau dan sangrai kopi robusta (25%, 50%, dan 100%), serta kelompok perlakuan kombinasi ekstrak biji hijau dan sangrai kopi robusta (50%:50%, 75%:25%, 25%:75%, 60%:40%, dan 40%:60%). Hasil analisis One Way Anova terhadap kelompok kontrol dan perlakuan didapatkan p=0,000. Hasil analisis Post Hoc Tukey HSD terhadap seluruh kelompok perlakuan dibandingkan dengan kelompok kontrol negatif didapatkan p=0,000. Zona hambat terbesar ditemukan pada kelompok kombinasi ekstrak 50%:50% dengan diameter sebesar 15,12 mm dan memiliki efek antibakteri yang sebanding dengan clindamycin dalam menghambat Staphylococcus aureus (p=0,121). Kata kunci : Aktivitas antibakteri; Biji hijau; Biji sangrai; Kopi Robusta (Coffea canephora L.); Staphylococcus aureusABSTRACTStaphylococcus aureus is the bacteria with the highest prevalence in diabetic ulcers which can be delayed the wound healing process. This is then exacerbated by the existence of resistance to various antibiotics. Coffee can be another alternative to overcome antibiotic resistance because it has antibacterial compounds, but roasting coffee beans will reduce the compounds responsible for antibacterial activity. The aim of this study is to identify antibacterial activity differences between green and roasted bean robusta coffee (Coffea canephora L.) extract and its combination against Staphylococcus aureus. This research used a post-test only control group design with an agar disc diffusion method (Kirby-bauer). Samples were divided into 13 groups, positive control clindamycin, negative control water sterile, green and roasted bean robusta coffee extract treatments group (25%, 50%, and 100%), and its combination (50%:50%, 75%:25%, 25%:75%, 60%:40%, and 40%:60%). One Way Anova test results on the control and treatment groups obtained p=0.000. Post Hoc Tukey HSD test results of all treatments compared to the negative control group obtained p=0.000. The largest inhibition zone was found in a 50%:50% extract combination with 15.12 mm in diameter , and its antibacterial effect was equal to clindamycin in inhibiting Staphylococcus aureus (p=0.121). Keywords : Antibacterial activity; Green bean; Roasted bean; Robusta Coffee (Coffea canephora L.); Staphylococcus aureus
Optimasi Formula SNEDDS (Self-Nanoemulsifying Drug Delivery System) Ekstrak Daun Kejibeling Menggunakan Metode SLD (Simplex Lattice Design) Mahiya Mahiya; Devi Ratnasari; Marsah Rahmawati Utami
Jurnal Ilmiah Wahana Pendidikan Vol 8 No 11 (2022): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (117.5 KB) | DOI: 10.5281/zenodo.6830330

Abstract

Kejibeling leaf as one part of the plant that is used as a natural medicine with various therapeutic effects. Plant extracts used as medicinal ingredients generally have poor solubility and result in low oral bioavailability. Kejibeling leaf extract is less soluble in water, so its pharmacologic effect is limited. Nanoemulsions can be an option for delivery systems which are expected to increase the solubility and bioavailability of oral administration. Nanoemulsifying formulation can be done through Self-Nanoemulsifying Drug Delivery System (SNEDDS). Simplex Lattice Design (SLD) is one of the optimization methods that can be used. This method is used to provide convenience in determining the optimal formula for the SNEDDS mixture. Testing on 14 formulas from Simplex Lattice Design resulted in the optimal formula for SNEDDS leaves of kejibeling with a composition of 2.22 (VCO): 54.23 (surfactant) : 43.55 (cosurfactant) with a transmittance value of 98.95% and an emulsification time of 47.12 seconds. Has a particle size of 11 nm with a PI value of 0.167 and a zeta potential value of -31.2 mV.