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SUHATNO -, SUHATNO
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Hubungan Invasi Pembuluh Limfe Dengan Metastasis ke Kelenjar Getah Bening Pelvis pada Kanker Serviks Stadium IB dan IIA HUTAPEA, MANUEL; -, SUHATNO; FAUZIAH, DYAH
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : "Dharmais" Cancer Center Hospital

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Objective: to know the result of Hematoxyllin-eosin and immunostainning D2-40 Podoplanin examination in detecting lymph vessel invasion (LVI) and to analyze correlation between lymph vessel invasion with pelvic lymph node metastasis in stage IB and IIA cervical cancer. Design of this research was cross-sectional study. The clinicopathological data of 41 patients with stage IB and IIA cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy (RHPL) at Dr. Soetomo Hospital, Surabaya, from January 2008 to June 2013 were retrospectively reviewed. Age, histology type, clinical stage, tumor size, number of removed pelvic lymph node, parametrial invasion and LVI were analyzed to define their correlation with pelvic node metastases. Immunohistochemical staining using MAb-D2-40 Podoplanin was used to detect lymph vessel invasion on the corresponding HE slides. Eligible criteria are paraffin wax embedded tissue from cervix cancer patients was diagnosed as cervix cancer, and patient’s medical record can be found and filled completely. Ineligible criteria are patients which is had chemotherapy or radiotherapy before surgery or patient’s paraffin wax embedded tissue was damaged. The correlation among variables was analyzed using Phi correlation test. Results: among of total 41 patients , lymph vessel invasion (LVI) was detected in 7 (17.07%) D2-40 Podoplanin slides, and 9 (21.95%) HE slides. Agreement rate with Kappa statistic between two method was significant, k = 0,381, p = 0,014. Lymph node metastasis was found in 6 (14.63%) samples. Positive LVI detected by D2-40 Podoplanin was significantly correlated with lymph node metastasis (? = 0.362; p = 0.02), but positive LVI detected by HE was not significantly correlated (? = 0.281; p = 0.072).
Profil Ekspresi Caspase-3 pada Kanker Ovarium Tipe Epitel Budiana, I Nyoman Gede; -, Suhatno; Hoesin, Faroek; -, Budiono
Indonesian Journal of Cancer Vol 7, No 3 (2013): Jul - Sep 2013
Publisher : "Dharmais" Cancer Center Hospital

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Penelitian ini bertujuan mengetahui profil ekspresi caspase-3 pada kanker ovarium tipe epitel. Rancangan penelitian ini adalah cross-sectional deskriptif. Sampel penelitian adalah pasien kanker ovarium di RSUD Dr. Sutomo, Surabaya, yang jaringan tumor ovariumnya telah diparafinisasi di Laboratorium Patologi Anatomi FK Universitas Airlangga Surabaya. Kriteria inklusi adalah blok parafin telah diperiksa secara histopatologi sehingga telah terdiagnosis pasti kanker ovarium tipe epitel dan catatan medis pasien bisa ditemukan serta terisi lengkap. Kriteria eksklusi adalah pasien pernah menjalani kemoterapi atau radiasi sebelum pembedahan dan blok parafin rusak sehingga tidak dapat digunakan. Ekspresi caspase-3 diperiksa secara imunohistokimia.Dari 42 subjek penelitian, didapatkan ekspresi caspase-3 positif sebanyak 47,6% dan ekspresi caspase-3 negatif sebanyak 52,4%. Ditemukan subjek penelitian dengan derajat diferensiasi sel baik lebih banyak mempunyai ekspresi caspase-3 positif dibandingkan dengan derajat diferensiasi sel sedang dan jelek (p=0,017). Subjek penelitian dengan stadium dini lebih banyak mempunyai ekspresi caspase-3 positif (p<0,001). Demikian juga subjek penelitian dengan residu tumor ? 1 cm lebih banyak mempunyai ekspresi caspase-3 positif (p=0,029).Kesimpulan: Terdapat perbedaan yang bermakna secara statistik ekspresi caspase-3 pada berbagai derajat diferensiasi sel, stadium, dan residu tumor pasca operasi primer pada kanker ovarium tipe epitel.Kata kunci: caspase-3, derajat diferensiasi sel, stadium, residu tumor 
Hubungan Invasi Pembuluh Limfe Dengan Metastasis ke Kelenjar Getah Bening Pelvis pada Kanker Serviks Stadium IB dan IIA HUTAPEA, MANUEL; -, SUHATNO; FAUZIAH, DYAH
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (847.694 KB)

Abstract

Objective: to know the result of Hematoxyllin-eosin and immunostainning D2-40 Podoplanin examination in detecting lymph vessel invasion (LVI) and to analyze correlation between lymph vessel invasion with pelvic lymph node metastasis in stage IB and IIA cervical cancer. Design of this research was cross-sectional study. The clinicopathological data of 41 patients with stage IB and IIA cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy (RHPL) at Dr. Soetomo Hospital, Surabaya, from January 2008 to June 2013 were retrospectively reviewed. Age, histology type, clinical stage, tumor size, number of removed pelvic lymph node, parametrial invasion and LVI were analyzed to define their correlation with pelvic node metastases. Immunohistochemical staining using MAb-D2-40 Podoplanin was used to detect lymph vessel invasion on the corresponding HE slides. Eligible criteria are paraffin wax embedded tissue from cervix cancer patients was diagnosed as cervix cancer, and patients medical record can be found and filled completely. Ineligible criteria are patients which is had chemotherapy or radiotherapy before surgery or patients paraffin wax embedded tissue was damaged. The correlation among variables was analyzed using Phi correlation test. Results: among of total 41 patients , lymph vessel invasion (LVI) was detected in 7 (17.07%) D2-40 Podoplanin slides, and 9 (21.95%) HE slides. Agreement rate with Kappa statistic between two method was significant, k = 0,381, p = 0,014. Lymph node metastasis was found in 6 (14.63%) samples. Positive LVI detected by D2-40 Podoplanin was significantly correlated with lymph node metastasis (? = 0.362; p = 0.02), but positive LVI detected by HE was not significantly correlated (? = 0.281; p = 0.072).
Co-Authors Budiono -, Budiono DYAH FAUZIAH, DYAH Faroek Hoesin, Faroek I Nyoman Gede Budiana MANUEL HUTAPEA, MANUEL