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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina International Journal of Biosciences and Biotechnology Buletin Udayana Mengabdi INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Jurnal Farmasi Klinik Indonesia Indonesian Journal of Cancer Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Journal of Health and Behavioral Science International Journal of Social Service and Research Indonesian Journal of Cancer Public Health and Preventive Medicine Archive Safari : Jurnal Pengabdian Masyarakat Indonesia

I Nyoman Gede Budiana

Gynecology Oncology Division, Obstetrics & Gynecology Department, Sanglah General Hospital

Author-ID : 268952

Arts Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Profil Ekspresi Caspase-3 pada Kanker Ovarium Tipe Epitel Budiana, I Nyoman Gede; -, Suhatno; Hoesin, Faroek; -, Budiono
Indonesian Journal of Cancer Vol 7, No 3 (2013): Jul - Sep 2013
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (611.688 KB)

Penelitian ini bertujuan mengetahui profil ekspresi caspase-3 pada kanker ovarium tipe epitel. Rancangan penelitian ini adalah cross-sectional deskriptif. Sampel penelitian adalah pasien kanker ovarium di RSUD Dr. Sutomo, Surabaya, yang jaringan tumor ovariumnya telah diparafinisasi di Laboratorium Patologi Anatomi FK Universitas Airlangga Surabaya. Kriteria inklusi adalah blok parafin telah diperiksa secara histopatologi sehingga telah terdiagnosis pasti kanker ovarium tipe epitel dan catatan medis pasien bisa ditemukan serta terisi lengkap. Kriteria eksklusi adalah pasien pernah menjalani kemoterapi atau radiasi sebelum pembedahan dan blok parafin rusak sehingga tidak dapat digunakan. Ekspresi caspase-3 diperiksa secara imunohistokimia.Dari 42 subjek penelitian, didapatkan ekspresi caspase-3 positif sebanyak 47,6% dan ekspresi caspase-3 negatif sebanyak 52,4%. Ditemukan subjek penelitian dengan derajat diferensiasi sel baik lebih banyak mempunyai ekspresi caspase-3 positif dibandingkan dengan derajat diferensiasi sel sedang dan jelek (p=0,017). Subjek penelitian dengan stadium dini lebih banyak mempunyai ekspresi caspase-3 positif (p<0,001). Demikian juga subjek penelitian dengan residu tumor ? 1 cm lebih banyak mempunyai ekspresi caspase-3 positif (p=0,029).Kesimpulan: Terdapat perbedaan yang bermakna secara statistik ekspresi caspase-3 pada berbagai derajat diferensiasi sel, stadium, dan residu tumor pasca operasi primer pada kanker ovarium tipe epitel.Kata kunci: caspase-3, derajat diferensiasi sel, stadium, residu tumorÂ

Penilaian Kualitas Hidup Pasien Kanker Serviks dengan Kemoterapi PaklitakselâKarboplatin di RSUP Sanglah Tunas, I Ketut; Yowani, Sagung C.; Indrayathi, Putu A.; Noviyani, Rini; Budiana, I Nyoman G.
Indonesian Journal of Clinical Pharmacy Vol 5, No 1 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Pemberian kemoterapi pada pasien kanker serviks stadium IIB-IIIB selain menimbulkan efek terapi juga menimbulkan efek samping berupa penurunan kualitas hidup. Penelitian ini dilakukan pada FebruariâJuni 2014 di Bagian Obstetri dan Gineklogi RSUP Sanglah Denpasar secara observasional dengan metode case study prospective. Pengumpulan data dilakukan menggunakan kuesioner EORTC QLQ C30 yang dikombinasikan dengan wawancara sebelum dan setelah kemoterapi paklitaksel-karboplatin sebanyak 3 seri pada pasien kanker serviks sel skuamosa stadium IIB-IIIB. Penelitian kualitas hidup dilakukan secara umum dan pada 15 domain yang memengaruhi kualitas hidup. Terdapat 12 pasien yang memenuhi kriteria inklusi. Pemberian kemoterapi regimen paklitaksel-karboplatin dapat meningkatkan kualitas hidup dengan penurunan nilai mean dari 48,083Â±5,451 menjadi 44,083Â±3,872. Terdapat perbedaan bermakna pada nilai kualitas hidup pasien sebelum dan setelah kemoterapi paklitaksel-karboplatin (nilai p=0,038). Terdapat penurunan kualitas hidup pada domain mual muntah, penurunan nafsu makan, fatigue, dan fungsi sosial. Domain dengan peningkatan kualitas hidup yaitu nyeri, fungsi fisik, fungsi emosional, sulit tidur, dan kesulitan keuangan. Pemberian kemoterapi paklitaksel-karboplatin pada 12 pasien dapat meningkatkan kualitas hidup pasien kanker serviks.Kata kunci: Domain kualitas hidup, kanker serviks, kualitas hidup, paklitaksel-karboplatinThe Assessment Quality of Life For Patients with Cervical Cancer Using Chemotherapy Paclitaxel-Carboplatin in Sanglah Chemotherapy administration to patients with cervical cancer stage IIB-IIIB not only causing a therapeutic effect but also decrease in quality of life. This study was conducted in FebruaryâJune 2014 in the Department of Obstetrics and Gynecology Sanglah Hospital with observational prospective case study method. Data were collected using the EORTC QLQ C30 questionnaire combined with interview before and after chemotherapy paclitaxel-carboplatin as much as 3 series in patients with squamous cell cervical cancer stage IIB-IIIB. Assesment was done in general quality of life and 15 domains that affect the quality of life. There were 12 patients who met the inclusion criteria. Administration chemotherapy with paclitaxel-carboplatin can improve the quality of life shown by decrease mean value from 48.083Â±5.451 to 44.083Â±3.872. There were significant differences in the value of the quality of life before and after being given chemotherapy paclitaxel-carboplatin (p-value 0.038). There were decrease in the quality of life of the domain nausea, vomiting, decreased appetite, fatigue, and social functions. Domains that have increased the quality of life is pain, physical functioning, emotional functioning, sleeplessness, and financial difficulties. Administration of chemotherapy paclitaxel-carboplatin can improve the quality of life of patients with cervical cancer.Key words: Domain quality of life, cervical cancer, paclitaxel-carboplatin, quality of life

Perbedaan Fungsi Ginjal, Hati dan Darah pada Pasien Kanker Serviks dengan Kemoterapi Bleomisin, OncovinÂ®, Mitomisin dan Karboplatin (Studi Kasus di RSUP Sanglah Denpasar Tahun 2015) Noviyani, Rini; Budiana, I Nyoman G.; Indrayathi, Putu A.; Niruri, Rasmaya; Tunas, I Ketut
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Â Â Regimen Bleomisin OncovinÂ® Mitomisin-Karboplatin (BOM-Karboplatin) sebagai kemoterapi tidak terlepas dari efek samping yang ditimbulkan yaitu toksisitas pada organ tubuh diantaranya adalah ginjal, hati, dan darah, dimana terjadinya toksikitas pada organ ginjal dapat diindikatorkan dengan parameter Serum Kreatinin dan Blood Urea Nitrogen (BUN). Terjadinya toksisitas pada organ hati dapat diukur dengan parameter SGOT dan SGPT serta toksisitas pada fungsi darah diindikatorkan dengan nilai hemoglobin, trombosit, leukosit. Belum terdapat data mengenai efek toksik dari kemoterapi BOM-Karboplatin pada pasien kanker serviks sel skuamosa stadium IIBâIIIB di RSUP Sanglah Denpasar, sehingga penelitian ini dilakukan melalui pemantauan terhadap fungsi ginjal, hati dan darah. Penelitian ini merupakan studi kasus observasional terhadap sembilan pasien yang diikuti selama tiga seri kemoterapi dari bulan Februari hingga Agustus 2015. Data serum kreatinin, BUN, SGOT, SGPT, hemoglobin, trombosit, dan leukosit yang diperoleh dianalisis menggunakan uji t berpasangan untuk data yang terdistribusi normal dan uji Wilcoxon untuk data yang tidak terdistribusi normal dengan tingkat kepercayaan 95% dan dikatakan berbeda bermakna bila p<0,05. Hasil studi kasus ini menunjukkan nilai serum kreatinin (p=0,530), BUN (p=0,553), SGOT (p=0,162), SGPT (p=0,054), Hemoglobin (p=0,034), Trombosit (p=0,028), dan Leukosit (p=0,011), sehingga dapat disimpulkan bahwa terdapat penurunan fungsi darah yang signifikan ditandai dengan adanya penurunan signifikan pada parameter hemoglobin, trombosit dan leukosit sebelum kemoterapi I dan sesudah kemoterapi III BOM-Karboplatin, sehingga diperlukan monitoring ketat terhadap fungsi darah pasien yang menerima kemoterapi BOM-Karboplatin di RSUP Sanglah Denpasar.Kata kunci: BOM-Karboplatin, fungsi darah, kanker serviks, kemoterapi, RSUP Sanglah, toksisitasThe Difference of Kidney, Heart and Blood Function on Cervical Cancer Patients with Chemotherapy, Bleomycin, OncovinÂ®, Mitomycin and Carboplatin (Case Study in Sanglah General Hospital, Denpasar in 2015) OncovinÂ® bleomycin mitomycin-carboplatin (BOM-carboplatin) regimen as chemotherapy is inseparable from the side effects it can caused which is toxicity to organs including the kidneys, liver, and blood where the toxicity in the kidneys can be indicated by the parameter of Serum Creatinine and Blood Urea Nitrogen (BUN), the occurrence of toxicity in the liver can be measured by the parameters of SGOT and SGPT, and toxicity to blood function can be indicated by the value of hemoglobin, platelets, leukocytes. The absence of data on the toxic effects of chemotherapy BOM-carboplatin in patients with squamous cell cervical cancer stage IIBâIIIB in Sanglah General Hospital in Denpasar, had made this research conducted through monitoring of kidney, liver and blood function. This study is an observational case study of nine patients who were followed for three rounds of chemotherapy from February to August 2015. Data of creatinine serum, BUN, SGOT, SGPT, hemoglobin, platelets, and leukocytes were analyzed using paired t-test for the data that were normally distributed and Wilcoxon test for the data that were not normally distributed with a confidence level of 95% and was said to be significantly different when p<0.05. The results of this case study demonstrated the value of serum creatinine (p=0.530), BUN (p=0.553), SGOT (p=0.162), SGPT (p=0.054), hemoglobin (p=0.034), platelets (p=0.028), and leukocytes (p=0.011) so it could be concluded that there was a significant decrease of blood function which could be characterized by a significant decrease in the parameters of hemoglobin, platelets and leucocytes before chemotherapy I and after chemotherapy III BOM-carboplatin, so it required strict monitoring of the blood function of the patients who received chemotherapy BOM-carboplatin in Sanglah General Hospital in Denpasar.Keywords: BOM-carboplatin, blood function, cervical cancer, chemotherapy, Sanglah General Hospital, toxicity

Evaluasi Nilai Blood Urea Nitrogen dan Serum Kreatinin pada Pemberian Kemoterapi Paklitaksel-Karboplatin pada Pasien Kanker Serviks Sel Skuamosa Stadium IIB-IIIB Noviyani, Rini; Suwiyoga, Ketut; Dewi, Anak A. A. W. P.; Niruri, Rasmaya; Tunas, I. K.; Budiana, I N. G.
Indonesian Journal of Clinical Pharmacy Vol 3, No 2 (2014)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2014.3.2.55

Kemoterapi paklitaksel-karboplatin merupakan salah satu terapi untuk kanker serviks. Toksisitas kemoterapi pada ginjal dapat dinilai menggunakan nilai Blood Urea Nitrogen (BUN) dan serum kreatinin. Pada penelitian potong lintang prospektif ini diperoleh 6 pasien kanker serviks yang memenuhi kriteria penelitian. Pemeriksaan kadar BUN dan serum kreatinin dilakukan sebelum kemoterapi pertama dan sesudah kemoterapi seri ketiga. Rentang waktu kemoterapi pertama ke kemoterapi ketiga adalah tiga minggu. Pengambilan sampel penelitian menggunakan consecutive sampling. Data penelitian dianalisis menggunakan paired test dengan interval kepercayaan 95% dengan SPSS 17.0. Hasil evaluasi nilai BUN dan serum kreatinin sebelum dan sesudah kemoterapi menunjukkan tidak terdapat perbedaan yang bermakna antara sebelum kemoterapi pertama dengan sesudah kemoterapi ketiga (p>0,05). Hasil penelitian ini dapat digunakan dokter sebagai pertimbangan untuk memberikan kemoterapi dengan regimen paklitaksel-karboplatin sesuai prosedur yang berlaku karena terbukti tidak menimbulkan penurunan fungsi ginjal pada pasien kanker serviks skuamosa.Kata kunci: BUN, kanker serviks, kemoterapi, paklitaksel-karboplatin, serum kreatininEvaluation of Blood Urea Nitrogen and Serum Creatinine in Squamous Cell Cervical Cancer Patients Stadium IIb-IIIb Who Receiving Paclitaxel- Carboplatin ChemotherapyPaclitaxel-carboplatin chemotherapy is one of cervical cancer therapy. Renal toxicity from chemotherapy can be assessed using the value of Â Blood Urea Nitrogen (BUN) and serum creatinine. In a prospective cross sectional study was obtained 6 cervical cancer patients who met the research criterias. Examination of BUN and serum creatinine performed before first and after third chemotherapy with the interval time of 3 weeks. Sampling method using consecutive sampling. Data were analyzed using paired test with 95% confidence intervals using the SPSS 17.0. BUN and serum creatinine before and after chemotherapy values obtained p>0.05. BUN and serum creatinine values showed no significant difference between before the first chemotherapy to after third chemotherapy. The doctor may consider using this combination chemotherapy in accordance with the procedures in force due to chemotherapy using paclitaxel- carboplatin shown to be effective and not cause renal toxicity in squamous cervical cancer patients.Key words: BUN, cervical cancer, chemotherapy, paclitaxel-carboplatin, serum creatinine

Uji Validitas dan Reliabilitas Kuesioner EORTC QLQ C-30 untuk Menilai Kualitas Hidup Pasien Kanker Ginekologi di RSUP Sanglah Denpasar Noviyani, Rini; Tunas, I Ketut; Indrayathi, Ayu; Budiana, Nyoman G.
Indonesian Journal of Clinical Pharmacy Vol 5, No 2 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Dampak dari penyakit dan pengobatan kanker dapat diukur dengan indikator kualitas hidup menggunakan kuesioner EORTC QLQ C-30. Penelitian cross-sectional dilakukan menggunakan 30 pasien. Data dikumpulkan melalui metode purposive sampling pada pasien yang memenuhi kriteria inklusi, yaitu wanita berusia 30â70 tahun yang didiagnosis kanker ginekologi, pernah menjalani kemoterapi di RSUP Sanglah Denpasar, dan bersedia menandatangani formulir persetujuan pasca penjelasan. Pasien yang tidak dapat berkomunikasi secara rasional menjadi bagian kelompok eksklusi. Validitas dan reliabilitas instrumen diuji menggunakan analisis faktor konfirmatori dengan program STATAÂ® versi 12. Hasil analisis faktor konfirmatori menunjukkan seluruh item pertanyaan memiliki loading factor ( ) > 0,70 sehingga seluruh butir pertanyaan adalah valid. Uji reliabilitas item memberikan nilai >0,50 untuk seluruh item pertanyaan yang menunjukkan seluruh item pertanyaan adalah reliabel. Hasil perhitungan validitas konstrak menghasilkan nilai VE= 0,90 dan reliabilitas konstrak (RF) adalah 1 yang berarti kuesioner EORTC QLQ C-30 memenuhi validitas dan reliabilitas konstrak. Kuesioner EORTC QLQ C-30 sebagai alat ukur kualitas hidup pasien kanker ginekologi di RSUP Sanglah Denpasar adalah valid dan reliabel.Kata kunci: Analisis faktor konfirmatori, kanker ginekologi, kuesioner EORTC QLQ C-30, RSUP Sanglah Denpasar, uji validitas dan reliabilitasÂ Validity and Reliability of EORTC QLQ C-30 Questionnaire in Assessing Quality of Life of Gynecological Cancer Patients in Sanglah Hospital Denpasar Â The impacts of cancer and its treatment can be measured by indicators of quality of life using the EORTC QLQ C-30 questionnaire. A cross-sectional study was done on 30 patients in Sanglah Hospital Denpasar. Data were collected through purposive sampling of patients who fit the inclusion criteria: women who were 30â70 years old were diagnosed with gynecological cancer, had chemotherapy in Sanglah Hospital, and had agreed to be part of the research by signing the informed consent form. Patients who were unable to rationally communicate became part of the exclusion group in this research. Validity and reliability of the tools in this study were tested using confirmatory factor analysis with STATA Â®version 12. Confirmatory factor analysis indicates that all items have a loading factor ( )> 0.70 so that it can be said that all the questions are valid. Reliability items have the value > 0.50 for all questions which shows all questions are reliable. Construct validity of the results of the calculation produce a value VE = 0.90 and the reliability construct (RF) of 1, which meet both validity and reliability constructs. Questionnaire EORTC QLQ C-30 as a measurement of the quality of life of gynecological cancer patients in Sanglah Hospital are valid and reliable.Key words: EORTC QLQ C-30 questionnaire, confirmatory factor analysis, gynecological cancer,Sanglah Hospital Denpasar, the validity and reliabilityÂ

Efek Kemoterapi Bleomisin, Vincristin, Mitomisin dan Karboplatin terhadap Massa Tumor dan Infiltrasi Parametrium pada Pasien Kanker Serviks: Studi Kasus di RSUP Sanglah Denpasar Suwiyoga, Ketut; Noviyani, Rini; Budiana, I Nyoman G.; Tunas, I Ketut; Indrayathi, Ayu; Niruri, Rasmaya
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Penggunaan regimen BOM-cisplatin untuk kemoterapi pasien kanker serviks masih belum memberikan hasil efektivitas yang memuaskan, sehingga dilakukan penggantian agen cisplatin dengan karboplatin. Kemoterapi BOM-karboplatin merupakan salah satu regimen terapi kanker serviks di RSUP Sanglah Denpasar. Informasi tentang efektivitas penggunaan BOM-karboplatin untuk kemoterapi kanker serviks masih sangat minim, maka dari itu penelitian ini dilakukan dengan melihat massa tumor dan infiltrasi parametrium. Penelitian ini merupakan penelitian studi kasus terhadap 9 pasien kanker serviks sel skuamosa stadium IIBâIIIB sebelum dan sesudah kemoterapi BOM-karboplatin di RSUP Sanglah dari bulan Februari hingga Agustus 2015 yang memenuhi kriteria. Pemeriksaan Massa Tumor dan Infiltrasi Parametrium (%CFS) dilakukan sebelum kemoterapi seri I dan sesudah kemoterapi seri III. Pengambilan sampel menggunakan consecutive sampling. Data penelitian dianalisis menggunakan uji normalitas yaitu uji Shapiro-Wilk, selanjutnya dianalisis menggunakan uji t berpasangan dengan taraf kepercayaan 95%, sedangkan data berdistribusi tidak normal ditranformasi ke bentuk fungsi logaritma lalu dianalisis dengan uji Wilcoxon. Berdasarkan analisis statistik diketahui bahwa terdapat penurunan bermakna pada massa tumor dan infiltrasi parametrium kiri sesudah 3 seri kemoterapi dengan nilai p<0,05 yaitu masing-masing p=0,001 dan p=0,025, tetapi tidak terdapat penurunan bermakna pada infiltrasi parametrium kanan dengan nilai p>0.05 yaitu p>0,083.Kata kunci: BOM-cisplatin, cancer free space, kanker serviks, RSUP Sanglah Effect of Chemotherapy Bleomycin, Vincristin, Mitomycin and Carboplatin by Tumor Mass and Infiltration Parametrial for Cervical Cancer Patients: Case Study in Sanglah General Hospital, DenpasarBOM-cisplatin regimen for chemotherapy for cervical cancer patients has not resulted high efficacy, hence a replacement of cisplatin with carboplatin is proposed. BOM-carboplatin chemotherapy is at present a treatment for cervical cancer patients in Sanglah Hospital in Denpasar. Information about the efficacy of using the BOM-carboplatin for cervical cancer chemotherapy is not provided, therefore this research performed by observing tumor mass and parametrial infiltration. This research was carried out using case study method on 9 patients with squamous cell cervical cancer stage IIBâIIIB before and after BOM-carboplatin chemotherapy at Sanglah Hospital from February until August 2015. Examination of tumor mass and parametrial infiltration (%CFS) conducted prior to chemotherapy series I and after chemotherapy series III. Sampling was done consecutively. The research data were analyzed using the normal distribution Shapiro-Wilk test continued by paired t-test with 95% confidence level, while data that is classified otherwise is transformed to logarithmic function and were analyzed using the Wilcoxon test. Based on statistical analysis, there is significant reduction in tumor mass and left parametrial infiltration after the third chemotherapy with (p<0.05) which are p=0.001 and p=0.025, but there is no significant reduction of right parametrial infiltration with p>0.05 that is p>0,083.Keywords: BOM-cisplatin, cancer free space, cervix cancer, Sanglah hospital

Expression of B-Cell Lymphoma Protein-2 (Bcl-2) and Caspase-3 are Related with Ovarian Cancer Budiana, I Nyoman G.
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (106.132 KB)

Objective: To determine the expression of Bcl-2 and caspase-3 and their relationship with ovarian cancer. Method: This study was a cross-sectional study. Speciment was tissue sample from ovarian cancer patients collected from parafinblock to determine the Bcl-2 and caspase-3 expression and demographic data obtained secondary from patients medical records. Expression of Bcl-2 and caspase-3 was examined by immunohistochemistry under light microscope with 400x light power field. The result was recorded as negative when the protein was expressed in 10% or less of cells and as a positive when the protein was expressed in more than 10% of cells. Result: A total of 45 samples was included as research subjects. 31 of 45 subjects showed the expression of Bcl-2 positive (68.9%), while the positive expression of caspase-3 was presented in 20 subjects (44.4%). There was a relationship between the expression of Bcl-2 with the expression of caspase-3 in ovarian cancer patients (p=0.002; Lambda=0.4). There was also a negative relationship, where the subjects with positive expression of Bcl-2 showed negative expression of caspase-3. In contrast, subjects with negative expression of Bcl-2 showed positive expression of caspase-3. Conclusion: There was a significance relationship between the expression of Bcl-2 with the expression of caspase-3 in ovarian cancer patients. [Indones J Obstet Gynecol 2014; 2-1: 33-39] Keywords: Bcl-2 expression, caspase-3 expression, ovarian cancer

Febrile Neutropenia pada Pasien Pascakemoterapi BUDIANA, I NYOMAN GEDE; FEBIANI, MELINDA
Indonesian Journal of Cancer Vol 11, No 2 (2017): April - June
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (180.183 KB)

ABSTRACTFebrile neutropenia (FN) is one of the side effects caused by chemotherapy due to hematopoetic suppression that cause neutropenia and other triggerring factors such as infection. More specifically, FN is defined as the temperature above 38,3oC at once oral temperature measurements or 38,0oC temperature within a period of time more than one hour with neutrophil counts less than 500/mm3 or neutrophil counts less than 1000/mm3 with predicted decline to 500/ mm3 within 48 hours. Febrile neutropenia defined as a medical emergency and oncology which has a high mortality rate. Although currently there is a great development in the prevention and therapy of FN, but this is still the most feared complication of cancer chemotherapy. This article summarizes the important aspects of the FN as well as itâs early detection and management that should be of concern for clinicians who decide to use chemotherapy as one of treatment modality for their patients.Â ABSTRAKFebrile neutropenia (FN) merupakan salah satu efek samping dari kemoterapi yang disebabkan oleh supresi hematopoesis yang menyebabkan neutropenia ditambah dengan faktor pencetus lain seperti infeksi. Secara lebih spesifik, FN didefinisikan sebagai temperatur di atas 38,3oC pada sekali pengukuran suhu oral atau suhu 38,0oC dalam jangka waktu lebih dari 1 jam dengan hitung jenis neutrofil kurang dari 500/mm3 atau hitung jenis neutrofil kurang dari 1000/mm3 dengan prediksi terjadi penurunan sampai 500/mm3 dalam waktu 48 jam. Febrile neutropenia ditetapkan sebagai kegawatdaruratan medis dan onkologi yang memiliki angka mortalitas tinggi. Walaupun saat ini terdapat perkembangan besar pada prevensi dan terapi FN, FN masih merupakan komplikasi yang paling ditakuti. Artikel ini merangkum aspek-aspek penting dalam deteksi dan penatalaksanaan FN, di mana hal ini perlu menjadi perhatian klinisi yang memutuskan untuk menggunakan kemoterapi sebagai modalitas pengobatan pasien.

Fertility-Sparing Surgery In Early Stage Cervical Cancer Budiana, IN Gede; Astawa Pemayun, Tjokorda Gede
Indonesian Journal of Cancer Vol 12, No 1 (2018): Jan - Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

Cervical cancer is a malignancy in women that cause major impacts, not only biologically, but also in various aspects of life. On patients during reproductive age, cervical cancer poses severe sexual and reproductive debilitation. Trend in the onset of first diagnosis is moving towards younger age, and mostly affect women in their reproductive age. This would give a bad impact on the sustainability of the patient’s reproductive function. Until now, fertilitysparing approach for the management of early-stage cervical cancer is still rare in Indonesia. However, some options of conservative surgical therapy are available for patients who desire fertility, namely conization, simple tracellectomy, radical trachelectomy, and also neoadjuvant chemotherapy. These options have been proven effective and safe, while maintaining patients’ reproductive functions. ABSTRAKKanker serviks merupakan suatu penyakit keganasan pada wanita yang memiliki dampak luas, tidak hanya pada tubuh penderita, namun juga berbagai aspek kehidupan penderita. Pada penderita di usia reproduktif, kanker serviks menimbulkan masalah seksual dan reproduksi yang berat bagi penderita. Kini usia dimana terjadinya kanker serviks mulai menunjukkan kecenderungan yang semakin muda yang tentunya memberikan dampak buruk terhadap keberlangsungan fungsi reproduksi pasien. Hingga saat ini, tatalaksana kanker serviks stadium awal dengan pendekatan fertility-sparing masih jarang dilakukan di Indonesia. Namun, beberapa pilihan terapi bedah konservatif tersedia bagi pasien yang menginginkan fertilitas, yakni konisasi, trakelektomi sederhana, trakelektomi radikal. hingga pemberian kemoterapi neo-adjuvant. Pilihan terapi ini telah terbukti efektif dan aman, serta mampu mem pertahankan fungsi reproduksi pasien.

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Objective: To determine the expression of Bcl-2 and caspase-3 and their relationship with ovarian cancer. Method: This study was a cross-sectional study. Speciment was tissue sample from ovarian cancer patients collected from parafinblock to determine the Bcl-2 and caspase-3 expression and demographic data obtained secondary from patients medical records. Expression of Bcl-2 and caspase-3 was examined by immunohistochemistry under light microscope with 400x light power field. The result was recorded as negative when the protein was expressed in 10% or less of cells and as a positive when the protein was expressed in more than 10% of cells. Result: A total of 45 samples was included as research subjects. 31 of 45 subjects showed the expression of Bcl-2 positive (68.9%), while the positive expression of caspase-3 was presented in 20 subjects (44.4%). There was a relationship between the expression of Bcl-2 with the expression of caspase-3 in ovarian cancer patients (p=0.002; Lambda=0.4). There was also a negative relationship, where the subjects with positive expression of Bcl-2 showed negative expression of caspase-3. In contrast, subjects with negative expression of Bcl-2 showed positive expression of caspase-3. Conclusion: There was a significance relationship between the expression of Bcl-2 with the expression of caspase-3 in ovarian cancer patients. Keywords: Bcl-2 expression, caspase-3 expression, ovarian cancer

Co-Authors Agrifa Eko Albert Sembiring Agung Bagus S. Satyarsa Anak A. A. W. P. Dewi Anak Agung Istri Ayu Detritha Sarasmarth Anak Agung Istri Mas Sugiantari Anom Suardika Arvinda C. Lalang Astawa Pemayun, Tjokorda Gede Budiono - Budiono -, Budiono Demetria Jesica Lim Dewi Lestarani Dewi, Anak A. A. W. P. Ernawati Ernawati Ernawati Evert Solomon Pangkahila Faroek Hoesin Faroek Hoesin, Faroek FEBIANI, MELINDA Heni Sunyoto Heru Christianto I Gd Ngurah Harry W.S I Gd Ngurah Harry W.S2 I Gde Sastra Winata I Gede Mega Putra I Gede Ngurah Harry Wijaya Surya I Ketut Surya Negara I Ketut Suwiyoga I Ketut Tunas I Made Darmayasa I Nyoman Satria Pratama I Wayan Artana Putra I Wayan Megadhana I. Lesmana Ida Ayu Dhitayoni Ida Bagus Gde Fajar Manuaba Ida Bagus Putra Adnyana Ida Bagus Rendra Kurniawan Artha Intan Puspa Jaqueline Sudiman Johnson N. Naat K.W.M. Kenwa Komang Ayu Kartika Sari L.H. Wirahartato L.P.D. Virayanti Luh Nyoman Mas Amita Luh Seri Ani Made Bagus Dwi Aryana Melinda Febiani Ni Kadek Ari Chintya Vedantari Ni Kadek Chindy Sarindra Bhavani Ni Kadek Dwi Karlina Nicholas Renata Lazarosony Nyoman Bayu Mahendra Nyoman Damar Widya Dharma P.A.T. Adiputra Pande Kadek Aditya Prayudi Putu Adi Sujana Putra Putu Ayu Indrayathi Putu Doster Mahayasa Putu Kartika Widyasari Putu Pradnya Paramitha Dewi Putu Raka Sanistia Sania Savitri Putu Srinata Dampati R. Niruri Rasmaya Niruri Rasmaya Niruri Rasmaya Niruri Rini Noviyani Ryan Saktika Mulyana Sagun Chandra Yowani Sari, Komang Ayu Kartika Stefanus K .H Stefanus K.H SUHATNO - SUHATNO -, SUHATNO Tasia Irma Endriani Tjokorda Gde Agung Suwardewa Tjokorda Gede Astawa Pemayun Yantus A.B. Neolaka Yosep Lawa

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