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All Journal Science and Technology Indonesia JFMR (Journal of Fisheries and Marine Research) Asian Journal of Aquatic Sciences Jurnal Abdi Insani Prosiding Konferensi Nasional PKM-CSR
Tambunan, Jeny Ernawati
Department Of Fish Product Technology, Faculty Of Fisheries And Marine Sciences, Universitas Brawijaya
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Journal : Asian Journal of Aquatic Sciences

 1 
IN SILICO STUDY OF TRITERPENOID IDENTIFIED FROM Ceriops decandra LEAVES AS INHIBITORS OF α-AMYLASE Yunita Eka Puspitasari; Jeny Ernawati Tambunan; Hardoko Hardoko
Asian Journal of Aquatic Sciences Vol 5 No 3 (2022): December
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/ajoas.5.3.429-439

Abstract

α-amylase has a pivotal role in catalyzing the cleavage of α-1,4-glycosidic bonds of polysaccharides to produce oligosaccharides. The inhibition of α-amylase delays the breakdown of carbohydrates, causing a reduction of blood glucose level absorption in diabetes patients. The exploration of α-amylase inhibitors has attracted because society assumed that utilizing herbal medicine reduced the side effect of prescribed drugs. Mangrove from genus Ceriops have been used as antidiabetic, but the mechanism as α-amylase inhibitors has not been reported. Consumption of leaves extract of C.decandra reduced blood glucose levels in diabetic rats, and triterpenoids have been identified from the leaves. With this in mind, this study aims to predict the molecular interactions between α-amylase (PDB ID: 4GQR) and the inhibitors, triterpenoid identified in C.decandra leaves, and to evaluate the potency of triterpenoid as α-amylase inhibitor. There are five triterpenoids identified in C.decandra leaves used as ligand tests, including lupenone, betulin, betulonic acid, betulinic acid, and lupeol. The descriptive method was applied in this investigation. This study was carried out from June to September 2022. Based on the molecular interactions, the binding affinity of triterpenoids was lower than the native ligand and control ligand. Lupenone, lupeol, betalonic acid, and betulinic acid inhibited α-amylase activity by non-competitive inhibition. It was predicted that betulin inhibited α-amylase activity through competitive inhibition
Co-Authors Agustinus Agustinus Aisah Girindra Akhmad Zainuri Althofian Arya Anies Chamidah Anies Chamidah Astried Vanessa Bambang Budi Sasmito Bambang Budi Sasmito Dhira Khurniawan Saputra Eddy Suprayitno Fahreza Okta Setyawan Gading Mahendra Hardoko Hardoko Hardoko Hardoko Heder Djamaludin Luh Ayu Hesa Frida Nanda Putri M. Nadhif Mikchaell Alfanov Pardamean Panjaitan Mikchaell Alfanov Pardamean Panjaitan Mochamad Arega Alfikri Mr. Hardoko Muhammad Ridha Naila Nency Romasni Sitanggang Sevia Medytya Shalma Dinda Shefita Meilana Titik Dwi Sulistiyati Ubaidillah Ubaidillah Vira Nur Titisari Yunita Eka Puspitasari Zulfia Rifka Ayu Kusuma