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All Journal INDONESIAN JOURNAL OF PHARMACY
Rob W.M. Van Soest, Rob W.M.
Institute for Systematics and Ecology, University of Amsterdam, P.O. Box 94766, 1090 GT Amsterdam, The Netherlands
Medicine & Pharmacology

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Isolation and structure identification of new alkaloids from the sponge Rhabdastrella rowi Hertiani, Triana; Edrada, RuAngelie; Van Soest, Rob W.M.; ., Sudarsono; Proksch, Peter
INDONESIAN JOURNAL OF PHARMACY Vol 19 No 3, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (385.253 KB) | DOI: 10.14499/indonesianjpharm0iss0pp128-136

Abstract

Chemical investigation on marine sponge Rhabdastrella rowi collected from Bali, Indonesia has been performed. This study was aimed to isolate and to identify structures of the sponge secondary metabolites as well as to test their cytotoxicity activity on mouse lymphoma cell line L5178Y.Isolation procedure was performed by using different chromatography techniques. NMR spectroscopy and mass spectrometry methods were used to identify the compounds chemical structures. Cytotoxicity of the isolates was tested on mouse lymphoma cell line L5178Y by using the microculture tetrazolium (MTT) assay.This study yielded two new alkaloids, quinolin-4-ol (1) and quninazolin-4-amine (2) which were found as minor constituents of Rhabdastrella rowi. Both compounds were observed as inactive against mouse lymphoma cell line L5178Y.Key words: Rhabdastrella rowi, sponge, alkaloids
Co-Authors Ali Djamhuri Peter Proksch, Peter RuAngelie Edrada, RuAngelie Triana Hertiani