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All Journal Jurnal Pembelajaran dan Biologi Nukleus Journal of Natural Sciences
Hermawan Purba
Sekolah Tinggi Ilmu Kesehatan (STIKes) Senior Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media

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Journal : Jurnal Pembelajaran dan Biologi Nukleus

 1 
The Utilisation of Coconut Water Waste into Nanocellulose and Potential Synergistic Effect of Asthma Plant (Euphorbia hirta L.) Extract as an Antibacterial Agent Lydia Br Barus; Fani Nuryana Manihuruk; Mesi Puspita Sari; Helen Anjelina Simanjuntak; Junius Gian Ginting; Hermawan Purba
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS (JPBN) Vol 9, No 3 (2023): Jurnal Pembelajaran Dan Biologi Nukleus November 2023
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v9i3.5060

Abstract

Skin infections contribute to one of the most significant global health issues. Acne, blisters, and abscesses are examples of skin infections that can be induced by Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. Treatment can be attempted through the development of nanotechnology in the form of nanocellulose. Nanocellulose, an organic substance, can be produced through the conversion of coconut water waste and Acetobacter xylinum bacteria. Future applications of nanocellulose formulated with a blend of extracts derived from natural sources, including Patikan Kebo (Euphorbia hirta L.), are anticipated to include the treatment of wound dressings (patches). Determining the antibacterial potential of nanocellulose was the objective of this study. The experimental research technique is implemented in phases. The extraction process was conducted by means of maceration, while the parallel streak method was utilized for antibacterial testing. The findings of the study indicated that the mean zone of inhibition for each treatment variable was as follows: 0 mm, 15.1 mm, 23.53 mm, and 23.06 mm for nanocellulose (serving as the negative control), nanocellulose and 0.5% extract, 1% extract, 1.5% extract, and clindamycin, respectively. Conclusion: Antibacterial activity was observed in nanocellulose extracts containing 1% and 1.5%
Inhibition Test of Ethanol from Extract Mangosteen Leaves (Garcinia mangostana L.) as an Acne Antibacterial Junius Gian Ginting; Nurbaiti Br. Singarimbun; Mestika Clemesiya Yulianti Daeli; Helen Anjelina Simanjuntak; Hermawan Purba; Lydia Br. Barus; Defcato Firmawati Zega
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS (JPBN) Vol 9, No 3 (2023): Jurnal Pembelajaran Dan Biologi Nukleus November 2023
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v9i3.5066

Abstract

A prevalent global infection that manifests frequently in Indonesia. An example of an infectious disease that is commonly encountered during adolescence is acne (Acne vulgaris). Antibiotics can be used to treat acne; however, their misuse can lead to the development of resistance; therefore, we are searching for inexpensive, readily available alternatives that are also secure. Mangosteen leaves (Garcinia mangostana L.) are one alternative to synthetic ingredients when it comes to the treatment of acne. Mangosteen leaves comprise xanthone derivative compounds that exhibit significant biological activity, including antioxidant, antibacterial, and antimicrobial properties. Therefore, this this study aimed to ascertain the inhibitory power of an ethanol extract derived from mangosteen leaves in order to determine its antibacterial activity against Staphylococcus epidermidis bacteria. Additionally, the compound content of the ethanol extract of mangosteen leaves was determined. The inhibition test was conducted by utilizing the paper disc technique, while the extraction method employed the maceration method. As indicated by the phytochemical screening test results, simplicia and ethanol extract of mangosteen leaves were found to contain steroids/triterpenoids, alkaloids, flavonoids, saponins, and tannins. The inhibition test outcomes against Staphylococcus epidermidis bacteria revealed the following: a diameter of 3.3 mm for bacteria at a concentration of 20%, 9.4 mm for bacteria at 40%, 10.4 mm for bacteria at 60%, 12.9 mm for bacteria at 80%, and 13.2 mm for bacteria at 100%
Co-Authors Cander Pasaribu Defcato Firmawati Zega Fani Nuryana Manihuruk Helen Anjelina Simanjuntak Junius Gian Ginting Lydia Br Barus Lydia Br. Barus Mesi Puspita Sari Mestika Clemesiya Yulianti Daeli Rahmiati Rahmiati Singarimbun, Nurbaiti Br Toberni S Situmorang Toberni S Situmorang Wan Yuli Anjani