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Pure Neural Leprosy Verdy, Verdy; Budiyanto, Arief; Siswati, Agnes Sri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Pure neural leprosy (PNL) is an infection by Mycobacterium leprae with clinical manifestation as nerve thickening, sensory nerve impairment, with or without motoric nerve involvement, and without skin lesion. Pure neural leprosy causes progressive degeneration of nerve function. Diagnosis establishement of PNL is difficult. Purpose: To discuss about PNL especifically in aspects of the diagnosis and therapy. Reviews: Gold standard in diagnosis of PNL is histopathological examination from nerve biopsy but this procedure is still difficult for various reasons. Some investigations can be done for PNL such as cytological fine needle aspiration, Mitsuda test, serology test for antibody anti-PGL1, electroneuromyography (ENMG), and polymerase chain reaction (PCR). Pure neural leprosy classification is based on findings of abnormality in neurological, immunological, and histopathological. Pure neural leprosy therapy is based on the classification of paucibacillary or multibacillary. Conclusions: The clinical and epidemiological findings plus with the electroneuromyography alteration were finally accepted as sufficient criteria to diagnose PNL. Pure neural leprosy therapy follows WHO regiment in accordance with the paucibacillary or multibacillary classification.Key words: pure neural leprosy, Mycobacterium leprae, nerve biopsy, anti-PGL-1, electroneuromyography.

Successful Treatment of Actinomycetoma with Combination of Cotrimoxazole and Tetracycline Verdy, Verdy; Dewi, Vina Ajeng Puspa; Budiyanto, Arief; Siswati, Agnes Sri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background: Actinomycetoma is an infection of chronic granulomatous disease on the skin, subcutaneous tissue, fascia, and bone, occured after trauma because of bacteria innoculation. Clinical features seem painless nodules, abscess, fistula, and sinusÂ with granulated discharge.Gold standard treatment for actinomycetoma is cotrimoxazole. Combination therapy with other antibiotic is needed to prevent resistance and improve therapeutic efficacy. Purpose: To discuss successful treatment of actinomycetoma with combination of cotrimoxazole and tetracycline Case: A 19-years-old woman had complained ofÂ chronic post-traumatic wounds since two years ago. Dermatological examination showed multiple painless nodules, sinus, and discharge on right dorsum pedis. Histopathological examination demonstrated sinus in dermis, suppurative granulomas, and SplendoreHoeppli phenomenon in dermis layer. Case Management: Combination therapy consist of cotrimoxazole 2x960 mg, that was given for 6 months and tetracycline 4x500 mg, that was given in the first 1 month.Â No side effects and drug allergy during and/or post treatment was found. After clinical evaluation for 6 months, successful of treatmentÂ was obtained and no recurrence was found. Conclusion: The combination therapy of cotrimoxazole for 6 months and tetracycline for 1 month was proven to be effective and no recurrence was found.Key words: actinomycetoma, cotrimoxazole, tetracycline.

Uji Potensi Antibakteri Sodium Ascorbyl Phosphate terhadap Propionibacterium acnes In Vitro Sulistiyowati, Yuli; Siswati, Agnes Sri
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2011)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v11i1.930

Akne vulgaris adalah gangguan pada unit pilosebaseus yang sering terjadi pada dewasa muda. Propionibacterium acnes adalah bakteri anaerob yang merupakan flora folikel dan berperan penting dalam patogenesis akne. Sodium Ascorbyl Phosphate (SAP) merupakan bentuk phosphate ester ascorbic acid yang mudah diserap oleh kulit, sehingga sering digunakan dalam produk kosmetik baik sebagai senyawa tunggal maupun campuran. Apabila senyawa ini terbukti mempunyai pengaruh terhadap jumlah koloni P. acnes, maka SAP dapat digunakan sebagai salah satu obat alternatif antiakne. Tujuan penelitian adalah untuk mengetahui kadar minimal SAP yang dapat menghambat pertumbuhan P. acnes invitro. Penelitian dilakukan secara eksperimental lab dengan bahan uji SAP yang dibuat dalam konsentrasi 0,5%, 1%, 1,5%, 2%, 2,5 %, 3%, 3,5%, 4%, 4,5 % kadar hambat minimal SAP terhadap P. acnes dengan metode dilusi cair. Penelitian ini dilakukan pengulangan sebanyak 3 kali. P. acnes cair di dapatkan dari Laboratorium Mikrobiologi FK UGM. Hasil penelitian menunjukkan bahwa kadar hambat minimal SAP terhadap Propionibacterium acnes adalah 2,5 % b/v. Dari penelitian ini dapat disimpulkan bahwa SAP memiliki potensi antibakteri terhadap Propionibacterium acnes.

Efek Antimikotik Minyak Mimba (Azadirachta indica) terhadap Dermatofita Estri, Siti Aminah Tri Susilo; Habib, Inayati; Suswardana, Suswardana; Siswati, Agnes Sri
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 2 (2006)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v6i2.1889

Recently, natural substances have been much developed for antimycotic medicine, such as neem tree that can be found in Indonesia. Oilfrom the neem seed has been proved to have antimycotic effect on non-dermatophytic fungi. The aim of this research was to determine antimycotic effects of neem oil on T. mentagrophytes, E. floccusum and M. gypseum by means of dilution method.This research utilized a simple experimental method. One ml of water and 1 ml of casein yeast glucose were placed into 10 tubes. One ml of pure neem oil was introduced into tube I and the liquids were mixed. Afterwards, 1 ml of solution from tube I was added into tube II. One ml of the solution from tube II was then added into tube III, and so forth up to tube X. Subsequently, 1 ml of dermatophytic suspension (106 cell/ml) was introduced into each tube. The growth of dermatophyte colony was examined on day 5 to 7, after being incubated at room temperature.Results of this research showed that on day 5, T. mentagrophytes began to appear in tube IV (neem oil concentration of 3,12%), while E. floccusum and M. gypseum appeared in tube III (6,25%). On day 7, all colonies began to appear in tube II; therefore, the minimal inhibitory concentration was 12,5%). Neem oil started to have antimycotic effect on T. mentagrophytes, E. floccusum and M. gypseum at a concentration of 6,25%.Akhir-akhir ini banyak dikembangkan bahan alami sebagai antimikotik, antara lain pohon mimba yang banyak terdapat di Indonesia Minyak dari bij i mimba terbukti mempunyai efek antimikotik terhadap berbagai jamur non dermatofita. Tujuan penelitian ini adalah untuk mengetahui efek antimikotik minyak mimba terhadap T. mentagrophytes, E. floccusum dan M. gypseum dengan metode dilusi.Penelitian menggunakan metode eksperimental sederhana. Pada 10 tabung dimasukkan 1 ml aqua dan lml casein yeast glucose. Pada tabung I ditambahkan 1 ml minyak mimba murni dan dicampur. Pada tabung ke II ditambahkan 1 ml larutan dari tabung I, begitu seterusnya sampai tabung ke X. Selanjutnya pada masing-masing tabung ditambahkan 1 ml suspensi dermatofita 106 sel/ml. Pertumbuhan koloni dermatofita dinilai pada hari ke 5-7 setelah diinkubasi pada suhu kamar.Hasil penelitian menunjukkan bahwa pertumbuhan koloni T. mentagrophytes pada hari ke-5 mulai tampak pada tabung ke-4 (konsentrasi 3,12%), koloni E. floccusum dan M. gypseum pada tabung ke-3 (konsentrasi 6,25%). Pada hari ke-7 semua koloni mulai tampak pada tabung ke-3, sehingga kadar hambat minimal pada konsentrasi 12,5%. Efek antimikotik minyak mimba terhadap T mentagrophytes, E. floccusum dan M. gypseum mulai tampak pada konsentrasi 6,25%.

Uji Potensi Antibakteri Sodium Ascorbyl Phosphate terhadap Propionibacterium acnes In Vitro Sulistiyowati, Yuli; Siswati, Agnes Sri
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2011)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v11i1.930

Akne vulgaris adalah gangguan pada unit pilosebaseus yang sering terjadi pada dewasa muda. Propionibacterium acnes adalah bakteri anaerob yang merupakan flora folikel dan berperan penting dalam patogenesis akne. Sodium Ascorbyl Phosphate (SAP) merupakan bentuk phosphate ester ascorbic acid yang mudah diserap oleh kulit, sehingga sering digunakan dalam produk kosmetik baik sebagai senyawa tunggal maupun campuran. Apabila senyawa ini terbukti mempunyai pengaruh terhadap jumlah koloni P. acnes, maka SAP dapat digunakan sebagai salah satu obat alternatif antiakne. Tujuan penelitian adalah untuk mengetahui kadar minimal SAP yang dapat menghambat pertumbuhan P. acnes invitro. Penelitian dilakukan secara eksperimental lab dengan bahan uji SAP yang dibuat dalam konsentrasi 0,5%, 1%, 1,5%, 2%, 2,5 %, 3%, 3,5%, 4%, 4,5 % kadar hambat minimal SAP terhadap P. acnes dengan metode dilusi cair. Penelitian ini dilakukan pengulangan sebanyak 3 kali. P. acnes cair di dapatkan dari Laboratorium Mikrobiologi FK UGM. Hasil penelitian menunjukkan bahwa kadar hambat minimal SAP terhadap Propionibacterium acnes adalah 2,5 % b/v. Dari penelitian ini dapat disimpulkan bahwa SAP memiliki potensi antibakteri terhadap Propionibacterium acnes.

Therapy selection for tinea corporis and cruris with commorbidity: 3 case series Yefta, Yefta; Winarni, Dwi Retno Adi; Siswati, Agnes Sri
Journal of General - Procedural Dermatology & Venereology Indonesia
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Dermatophytosis is a superficial (skin, hair and nails) fungal infection caused by dermatophyte group fungi (Trichophyton, Epidermophyton and Microsporum). Immunocompromised conditions cause fungal infections to become more widespread and require consideration of therapy. Case Illustration: This case series represented three cases of tinea corporis and tinea cruris in patients with comorbidities. The first case was tinea corporis and tinea cruris in a patient with congestive heart failure with oral terbinafine therapy. The second case was tinea corporis and tinea cruris in a patient with bilateral fourth degree hydronephrosis with oral griseofulvin therapy. The third case was tinea corporis in a patient with autoimmune hemolytic anemia with oral itraconazole therapy. A two-week post-systemic antifungal evaluation gave good results in all of the patients. Discussion: Selection of antifungals in dermatophytosis cases considering the patient's condition (contraindications and side effects that can be caused) provides a good outcome in patients with comorbidities. Conclusion: Dermatophytosis (tinea corporis and tinea cruris) is common in immunocompromised patients. This is due to decreased immunity causing dermatophytes to develop easily on the skin. Selection of the right therapy, considering comorbid conditions is important in order to get the best results for the patients.

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