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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Medical and Health Science Journal
Hans Lumintang, Hans
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Health Professions Immunology & microbiology Public Health Social Sciences

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Cara Penularan HIV & AIDS Di Unit Perawatan Intermediate Penyakit Infeksi (UPIPI) RSUD Dr. Soetomo Surabaya Astindari, Astindari; Lumintang, Hans
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (276.29 KB) | DOI: 10.20473/bikkk.V26.1.2014.1-5

Abstract

Latar belakang: Kasus HIV & AIDS makin lama makin meningkat. Sejak pertama kali dilaporkan pada tahun 1987 sampai 2009, di Indonesia tercatat 3.492 orang meninggal dunia karena penyakit ini. Cara penularan HIV & AIDS di Indonesia selalu mengalami perubahan. Awalnya cara penularan terjadi melalui hubungan heteroseksual. Kemudian peningkatan jumlah pengguna narkoba suntik (penasun) di Indonesia menyebabkan cara penularan HIV & AIDS juga mengalami perubahan karena penularan bisa terjadi melalui penggunaan jarum suntik bersama di kalangan para penasun. Saat ini cara penularan HIV & AIDS kembali lagi, terutama melalui hubungan heteroseksual. Perubahan cara penularan HIV & AIDS dari kelompok penasun ke heteroseksual mempengaruhi strategi pencegahan penularan HIV & AIDS di Indonesia, khususnya di RSUD Dr. Soetomo Surabaya. Tujuan: Mengevaluasi cara penularan HIV & AIDS di UPIPI RSUD Dr. Soetomo Surabaya tahun 2006-2010. Metode: Penelitian deskriptif, retrospektif tentang cara penularan HIV & AIDS di UPIPI RSUD Dr. Soetomo Surabaya tahun 2006 – 2010. Hasil: Kasus baru HIV & AIDS di UPIPI RSUD Dr. Soetomo Surabaya tahun 2006-2010 didapatkan 3.090 kasus, dengan perbandingan pasien laki-laki lebih banyak dari pasien perempuan. Cara penularan tertinggi melalui hubungan seksual yaitu 63,5%, cara penularan berikutnya melalui penasun 24,8%, penasun + seksual 6,3%, dan perinatal 3,2%. Cara penularan melalui heteroseksual makin meningkat dari tahun 2006 sebanyak 186 orang (47,1%) menjadi 509 orang (71,9%) pada tahun 2010. Simpulan: Cara penularan HIV & AIDS di UPIPI RSUD Dr. Soetomo mengalami perubahan, yang semula terbanyak melalui penasun pada tahun 2005 berubah melalui heteroseksual pada tahun 2010. Hal itu akan mempengaruhi strategi upaya pencegahan penyakit tersebut. Kata kunci: studi retrospektif, HIV & AIDS, penularan, heteroseksual, IDUs, penasun, perinatal.
Correlation of Expression p16 on Genital Wart Lesions with Various Degrees of Cervical Dysplasia Rahmawati, Asri; Damayanti, Damayanti; SP, Cita Rosita; Lumintang, Hans
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.416 KB) | DOI: 10.20473/bikkk.V26.3.2014.1-7

Abstract

Introduction: Infection of Human Papillomavirus (HPV) can cause condylomata acuminata. High-risk HPV types have proteins E6 and E7 called “oncoprotein” for its role in the occurrence of cancer. E7 protein causing no active bond pRb and E2F is regulated by CDK inhibitors, such as p16INK4a . Overexpression p16INK4a could be obtained from pre cancerous lesions. Pap smear, the standard screening method, is performed to detect early malignancy of the cervix, but have low sensitivity. The presence of tumor markers, p16INK4 ,will help early detection of malignancy. Purpose: To evaluate the profile of p16INK4a expression in condylomata acuminata lesions with various degrees of cervical dysplasia. Methods: Discriptive, observational, cross seetional study by performed p16INK4a immunohistochemical examination in lesions condylomata acuminata and cytologic examination on cervical biopsy. Results: Results of cervical cytology (pap smear) from 18 samples showed Low-grade Squamous Intraepithelial Lesions (LSIL) in 10 patients (55.6%) and Negative for Intraepithelial Lesion or Malignancy (NILM) in 8 patients (44.4%). Immunohistochemical examination obtained p16INK4a expression with score of 1 (sporadic) in 8 patients (44.4%), with score of 2 (focal) in 7 patients (38.9%) and with score of 3 (diffuse) in 3 patients (16.7%).  From 3 patients with diffuse expression of p16INK4a , 2 patients (66,6%) showed LSIL from cytology cervix and 1 patient (33,3%) revealed NILM. Spearman correlation test results showed no significant correlation between p16INK4a expression in cervical dysplasia with p = 0.24 (p> 0,05). Conclusion: There were three samples of diffuse, with most of Low-grade Squamous Intraepithelial Lesions (LSIL) in cervical dysplasia, it indicates there is a potential of p16INK4a as a marker of malignancy in condylomata acuminata. Key words : condylomata acuminata, p16INK4a , cervical dysplasia.
Profile of Peanut Spesific-IgE in Atopic Dermatitis L, Indiarsa Arief; Lumintang, Hans; Ervianti, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.195 KB) | DOI: 10.20473/bikkk.V26.3.2014.1-5

Abstract

Background : Atopic Dermatitis (AD) is a chronic reccurent disease. One of the environmental factors which possibly involved in the reccurency of AD is food allergy such as peanut. Peanut allergy in the pathogenesis of AD is by induction IgE and T cells. Peanut-spesific IgE allergen are observed in AD patient. Purpose: To identify the distibution of serum IgE concerning the peanut antigens according to AD. Methods:This trial was cross sectional descriptive study, which studied 33 atopic dermatitis patients, which fulfill inclution criterias.We describe the anamnesis, physical examination, peanut-spesific IgE  and the severity of AD using SCORAD index. Results: There were 7 patients (21,2%) with positive result of peanut-spesific IgE. The positive result of peanut-spesific IgE were noted most often on AD patients who suffer from severe grade of AD severity score (85,7%) but not found in class 3 or more (where antibody can detect significanly, often clinical manifestasion appeared when had sensitisation). Conclusion: The positive result of peanut-spesific IgE class 1 (0,35- 0,7 IU/mL)  5 people (15,1%) and  class 2 (0,7-3,5 IU/mL) 2 people (6,1%) were noted most often on AD patients who suffer from severe grade of AD severity scoreKey words: atopic dermatitis, peanut-spesific IgE.
IMUNOHISTOKIMIA PADA KONDILOMATA AKUMINATA Widyaswari, Meidyta Sinantryana; Lumintang, Hans; Soemarno, Troef
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): February
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Condylomata Acuminata (CA) is a sexually transmitted disease caused by the Human Papilloma Virus (HPV) type-specific and may be simultaneously co-infected with other HPV types associated with malignancy. Purpose: To differentiate between CA and histopathological of malignancy by immunohistochemistry. LiteratureReview: CA refers to benign epidermal proliferation caused by the HPV types 6 and 11, but co-infection with high- risk HPV types are common. The clinical presentation of CA can’t differentiate between benign or preneoplastik diplasia lesions. Koilocytes considered pathognomonic for HPV lesions, these findings sometimes don’t appear on CA, and histopathology was not accurate, that immunohistochemistry with MIB-1 (Ki-67) and p16 can beused. Conclusion: Immunohistochemistry examination can help differentiate the diagnosis between malignancy or non- malignancy in the case of CA.
Co-Authors Asri Rahmawati Astindari Astindari, Astindari Cita Rosita SP, Cita Rosita Damayanti Damayanti Evy Ervianti Indiarsa Arief L, Indiarsa Arief Meidyta Sinantryana Widyaswari, Meidyta Sinantryana Troef Soemarno, Troef