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All Journal HOSPITAL MAJAPAHIT (JURNAL ILMIAH KESEHATAN POLITEKNIK KESEHATAN MAJAPAHIT) Journal of Holistics and Health Sciences (JHHS) Hospital Majapahit : Jurnal Ilmiah Kesehatan Politeknik Kesehatan Mojokerto STRADA Jurnal Ilmiah Kesehatan Prima Wiyata Health Jurnal Pengabdian Masyarakat Bangsa JPK : Jurnal Penelitian Kesehatan
Hany Puspita Aryani, Hany
Sekolah Tinggi Ilmu Kesehatan Husada Jombang, Indonesia
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Journal : STRADA Jurnal Ilmiah Kesehatan

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An IGF-1 Levels Decrease in SOPK-RI Model Mice After A Low-Carb Diet Ermawati Ermawati; Budi Santoso; Widjiati Widjiati; Hany Puspita Aryani
STRADA Jurnal Ilmiah Kesehatan Vol. 9 No. 2 (2020): November
Publisher : Institut Ilmu Kesehatan STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.546 KB) | DOI: 10.30994/sjik.v9i2.298

Abstract

The aim of this study is to analyze the IGF-1 levels decrease in mice modeled by Polycystic Ovary Syndrome Insulin Resistance post carbohydrate high in protein. True Experimental Design with a Posttest Control Group Design research using 36 tails, female Wistar Rattus Norvegicus Strains, 3 months, 100-200 grams and randomly divided into 3 groups, namely K-(n =12, negative control group), K+(n=12, positive control group) and KP(n=12, treatment group). SOPK-IR modeling is done by mice in the injection of the hormone testosterone provionate at a dose of 100 mg/kg BW for 28 days, on the last day after injection a vaginal swab is performed to identify the condition of diestrus. The measurement of IGF-1 levels used the Enzyme-Linked Immunosorbent Assay method. Data analysis techniques used ANOVA test and LSD post hoc test. The results obtained mean levels of IGF-1 at K- (234.126±32.568) ng/mL, K+ (169.662±30.150) ng/mL, KP (146.528±29.562) ng/mL (p=0.000)
Co-Authors Budi Santoso Elly Rustanti Ermawati Ermawati Karisma Dwi Ana Rahayu, Hanis Kusumawati Rista Dian Anggraini Sri Wulandari Sulistiawati Sylvie Puspita Warda Anil Masyayih Widjiati Widjiati Yoga Rosita Yoseph Copertino Tna’auni