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All Journal Jurnal Farmasi Udayana
Angela Alysia Elaine
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Medicine & Pharmacology

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Studi In Silico Senyawa Daun Sirsak (Annona muricata L.) Sebagai Inhibitor BRAF V600E Pada Kanker Melanoma Audry Rahma Dewayani; Salsabil Ghaliya; Natashya Parameswari; Alya Puteri Agustina Pribadi; Husna Muharram Ahadi; Diah Lia Aulifa; Angela Alysia Elaine; Bernap Dwi Putra Sitinjak
Jurnal Farmasi Udayana Vol. 11, No. 2, Tahun 2022
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2022.v11.i02.p07

Abstract

Melanoma is a cancer that develops in melanocytes and manifests itself on the skin as lumps and uneven skin pigmentation. A chemotherapeutic medication called Vemurafenib is one of the medicines used to treat this malignancy. Chemotherapeutic drugs, on the other hand, are known to induce a variety of adverse effects in the body, thus alternative substances with the same potential but fewer side effects must be sought. This study was conducted utilizing an in silico technique, which included molecular docking, as well as Lipinski rules and PreADMET to predict the pharmacokinetic profile. Compounds found in soursop leaves (Annona muricata L.) have been shown to inhibit cell division by interacting with the BRAF V600E receptor. Reticuline has a Gibbs energy of -8.78; a 395.39 nM inhibition constant; and binds to the amino acids GLN A:530, CYS A: 532, and ASP A: 594.
Co-Authors Alya Puteri Agustina Pribadi Audry Rahma Dewayani Bernap Dwi Putra Sitinjak Diah Lia Aulifa Husna Muharram Ahadi Natashya Parameswari Salsabil Ghaliya