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All Journal Indonesian Journal of Chemistry Indonesian Journal of Pharmaceutical Education
Mohamad Adam Mustapa
Department Of Pharmacy, Faculty Of Sport And Health Sciences, Universitas Negeri Gorontalo, Gorontalo 96128, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Journal : Indonesian Journal of Chemistry

 1 
Evaluation of the Antiplasmodial Properties of Andrographis paniculata (Burm.f.) and Peperomia pellucida (L.) Kunth Nurhayati Bialangi; Mohamad Adam Mustapa; Yuszda Salimi; Weny Musa; Ari Widiyantoro; Agus Malik Ibrahim; Boima Situmeang; Julinton Sianturi
Indonesian Journal of Chemistry Vol 23, No 1 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.74481

Abstract

Plasmodium species are the infectious agents that are responsible for malaria, a disease that claims the lives of approximately 400,000 people annually. The fact that drug resistance against malaria is on the rise suggests that new antimalarial compounds need to be discovered. It is well known that medicinal plants present the best opportunity for the identification of novel antimalaria chemicals. Both the Andrographis paniculata (Burm.f.) and Peperomia pellucida (L. Kunth) species have been tested for their antiplasmodial ability against the Plasmodium falciparum strain. The P. pellucida (L. Kunth) species has also been subjected to in vitro and in vivo biological research. P. pellucida was used to isolate the steroid known as 3-hydroxy-24-ethyl-5,22-cholestadiene (1) and the triterpenoid known as 3-hydroxy-9-lanosta-7,24E-dien-26-oic acid (2). Both compounds were then tested for their activity in vitro. In the mice model, triterpenoid 2 had a substantial chemo-suppressive impact.
Co-Authors Abto, Nazarudin Agus Malik Ibrahim Ari Widiyantoro Boima Situmeang Julinton Sianturi NUR AIN THOMAS Nurhayati Bialangi Weny Musa Yuszda K. Salimi