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Haqqi Anajili Setyanto, Haqqi Anajili
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6-Gingerol from Zingiberaceae as a Result of Reverse Docking for Prostate’s Cancer Potential Drug Candidate Setyanto, Haqqi Anajili; Widiansyah, Arindra Trisna; Mustofa, Zainul
Proceeding International Conference on Global Resource Conservation Vol 6, No 1: Proceeding of 6th ICGRC 2015
Publisher : Proceeding International Conference on Global Resource Conservation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.209 KB)

Abstract

Prostate cancer is a cancer that attacks the prostate gland causing the death rate which is high enough. One of the causes of prostate cancer is the androgen receptor (AR) in the gland cells that initiates the formation of excess cell proliferation, thus causing prostate cancer. AR inhibitor that is known is antiandrogen (biculatamide and enzalutamide). This study aimed to test the 6-gingerol compound of ginger as an AR inhibitor drug candidate for prostate cancer using silico methode. The 3D structure of the 6-gingerol compound was taken from PubChem, the prediction of targeted protein used SwissTargetPrediction and Pharmapper, analysis and docking 6-gingerol and antiandrogens with AR using Pyrx software, visualization compounds and protein interactions using PyMOLsoftware. Visualization results shows that the interaction of 6-gingerol, biculatamide, and enzalutamide with AR have the same site. This proves that the 6-gingerol is potential as anAR inhibitor candidate.Keywords: 6-gingerol; prostate’s cancer; reverse docking
The Inventory of Aquatic Macroinvertebrates in Various Waterfall in East Region of Malang, East Java Wijayanti, Erna; Fauzi, Ahmad; Widiansyah, Arindra Trisna; Mustofa, Zainul; Setyanto, Haqqi Anajili; Sukoco, Restu Megadiana; Nuha, Ulin; Fadilah, Rizka Elan
Proceeding International Conference on Global Resource Conservation Vol 6, No 1: Proceeding of 6th ICGRC 2015
Publisher : Proceeding International Conference on Global Resource Conservation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.209 KB)

Abstract

Indonesia as Maritime Island has many water regions. Waterfall is one of the water region that has a large number of aquatic macroinvertebrates. The aim of this research is to collect and identify the various aquatic macroinvertebrates that can be found in several waterfalls in east Region of Malang, East Java. The research was carried out on September until November 2015 in six waterfalls: Coban Jahe, Coban Pelangi, Coban Trisula, Coban Kembar, Coban Ringin Gantung and Coban Pitu. Dragnet was used to collect the samplesof aquatic macroinvertebrates in some sampling point. The result of this research was found 38 families that belonged to 18 ordo in 6 different classes: Insecta, Oligochaeta, Gastropoda, Hirudinae, Turbellaria, and Crustacea. The information about the inventory of aquatic macroinvertebrates will give another suggestion for the local government to conserve this animals especially waterfall environment, not only as tourist area but also as a source of knowledge to do another research. Keywords: Aquatic macroinvertebrates; inventory; Malang; waterfalls
Co-Authors Arindra Trisna Widiansyah, Arindra Trisna Erna Wijayanti I Gusti Bagus Wiksuana Restu Megadiana Sukoco, Restu Megadiana Rizka Elan Fadilah, Rizka Elan Ulin Nuha, Ulin Zainul Mustofa, Zainul