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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Aisyah : Jurnal Ilmu Kesehatan
Paulus Sugianto, Paulus
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Studi Penggunaan Natrium Valproat Kurang Dari Tiga Bulan Terhadap Magnesium Serum Dan Jumlah Kejang Pasien Epilepsi Di RSUD Dr. Soetomo Latuasan, Ivana Rahayu; Sugianto, Paulus; Kasih, Elisabeth; Octavia, Evi
Jurnal Farmasi Sains dan Terapan Vol 5, No 1 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.402 KB) | DOI: 10.33508/jfst.v5i1.2049

Abstract

Epilepsy is a brain disorder characterized by a tendency to cause continuous epilepsy attacks with neurobiological, cognitive, psychological and social consequences. The appearance of temporary signs or symptoms is caused by abnormal and excessive neuron activity in the brain. Sodium valproate can be used as epilepsy therapy because it is effective in inhibiting seizures, partial seizures, and tonic-clonic seizures. The mechanism of action of sodium valproate in the treatment of epilepsy is to increase the inactivation of Na + channels, thereby reducing the nerve's ability to transmit electric charges. Magnesium is a potential modulator of seizure activity because of its ability to inhibit excitation through N-methyl D-aspartate receptors. The aim of this study was to determine serum magnesium levels with sodium valproate treatment and the number of seizures as well as to identify drug-related problems in epilepsy patients who were less than three months old. The research was conducted in the Electroencephalography Room of the Regional Hospital Dr. Soetomo Surabaya by using observational methods in the form of prospective studies using data collection sheets and questionnaires. Samples were taken from July 1 to September 30, 2017. Based on laboratory results, the average magnesium content of patients with seizures was 2.22 mg / dL while non-seizure patients were 2.08 mg / dL. The conclusion of this study is that the use of sodium valproate does not affect magnesium levels in epilepsy patients and epilepsy patients who get sodium valproate therapy have a lower risk of seizures than those who do not get sodium valproate medication.
Studi Penggunaan Obat Phenytoin Kurang dari Tiga Bulan terhadap Kadar Magnesium Serum dan Jumlah Kejang Pasien Epilepsi di RSUD DR. Soetomo Surabaya Sanjiwani, Kadek Siska Febri; Sugianto, Paulus; Kasih, Elisabeth
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.33508/jfst.v4i2.2180

Abstract

Epilepsy is a clinical phenomenon associated with an electrical explosion or excessive abnormal depolarization, which occurs in focus in the brain which causes a paroxysmal awakening. One of the anti-epilepsy drugs is phenytoin which belongs to the hydantoin class. This study aims to describe the serum Mg levels in epilepsy patients with phenytoin drug therapy in Dr. Soetomo General Hospital with a treatment period of less than three months and to identify DRP problems (Drug Related Problems). The method used in this study is prospectively presented by descriptive method (observational). The population in this study were epilepsy patients who were treated at the RSUD dr. Soetomo Surabaya with a sample of 28 epilepsy patients treated at the Outpatient and EEG Neurology Room at Dr. Soetomo General Hospital Surabaya. Results showed that Mg2+ levels in 28 patients with the highest magnesium levels were 2.46 mg / dL. While the lowest magnesium content is 1.78 mg / dL. Conclusions Patients' magnesium levels are still within the normal range but it has not been concluded that phenytoin can increase serum Mg2+ levels and there is no significant difference between phenytoin therapy in epilepsy patients
Correlation between Blood and Cerebrospinal Fluid (CSF) Neutrophil-Lymphocyte Ratio With Bacterial Meningitis Prognosis Patient Sugianto, Paulus; Machin, Abdulloh; Sudibyo, Devi Ariani; Hamdan, Muhammad
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (651.743 KB) | DOI: 10.30604/jika.v8i2.1993

Abstract

Bacterial Meningitis is a bacterial infection of the central nervous system’s protective membranes called the meninges. Bacterial Meningitis has a high disability and case fatality rate. This inflammatory process not only manifests in CSF but also systemically. The neutrophil-lymphocyte ratio(NLR) can be a predicting factor of severity and prognosis in systemic inflammation. Only a few studies in Indonesia evaluate the neutrophil-lymphocyte ratio as a predictor of mortality in adult bacterial meningitis. This study also aimed to compare neutrophil-lymphocyte ratio in LCS and systemic as a predictor of mortality in patients with adult bacterial meningitis. This is an analytic cross-sectional study in Dr. Soetomo's general hospital—a total sample of 44 bacterial meningitis patients from the inpatient ward of Dr. Soetomo General Hospital Surabaya. The blood Neutrophil- Lymphocyte ratio, Glasgow Coma Scale upon admission, and  Absolute lymphocyte count were significant with bacterial meningitis outcome with p-value less than 0.05. Early detection of bacterial meningitis patient prognosis could alert the healthcare provider to give careful monitoring and aggressive treatment. Abstrak: Meningitis bacterial adalah inflamasi akibat bakteri di selaput otak dan sumsum tulang belakang bernama meningen. Meningitis merupakan penyakit dengan angka kematian dan angka kecacatan yang cukup tinggi walaupun sudah memberikan pengobatan yang tepat. Proses inflamasi ini terjadi tidak hanya pada system saraf pusat namun juga terjadi di seluruh tubuh. Rasio neutrophil-limfosit pada darah selama ini dapat menjadi tanda derajat keparahan dan prognosis pada kasus inflamasi sistemik. Hanya beberapa penelitian yang mencari tentang hubungan rasio limfosit dan neutrophil pada cairan serebrospinal apakah dapat menunjukan derajat keparahan pada infeksi meningitis bakteri. Dalam penelitian ini juga ingin mencari rasio limfosit dan neutrophil darah apakah selaras dengan rasio di dalam cairan serebro spinalis. Penelitian ini merupakan studi reptrospektif kroseksional analitik. Total sampel dari populasi ini adalah 44 yang memenuhi kriteria inklusi dan ekslusi. Secara Statistik didapatkan rasio neutrophil-limfosit darah, tingkat Glassgow Coma Scale saat masuk, dan nilai limfosit absolut signifikan dalam menentukan prognosis pasien dengan meningitis bakteri dewasa (P kurang dari 0.05 ).
Co-Authors Elisabeth Kasih Evi Octavia Fidiana, Fidiana Latuasan, Ivana Rahayu Machin, Abdulloh Muhammad Hamdan Muhammad Hamdan1, Riani Wisnujono1, Yudha Haryono1, Abdulloh Machin1, Dian Puspitarini1 Muhammad Ikbal Ngakan Made Rai Widjaja Nugraha, Priya Pardede, Sabrina Melisa Rahmarini, Edfina Sanjiwani, Kadek Siska Febri Sudibyo, Devi Ariani Surpa, Rio Tasti Wahyuning Hadi, Deby Wahyuninghadi, Debi Widjiati Widjiati, Widjiati