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All Journal Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education PAMERI : Pattimura Medical Review
Yuniasih M. J. Taihuttu
Fakultas Kedokteran Universitas Pattimura
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : PAMERI : Pattimura Medical Review

 1 
JENIS LEUKOSIT MENCIT (Mus musculus) PASCA STRES AKUT DENGAN PERLAKUAN EKSTRAK ETANOL BIJI PALA (Myristica fragrans Houtt) Zulhaimi Hendrajid; Yuniasih M. J. Taihuttu; Parningotan Y. Silalahi; Laura B. S. Huwae; Vina Z. Latuconsina
PAMERI Vol 2 No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.865 KB) | DOI: 10.30598/pamerivol2issue2page103-116

Abstract

Glucocorticoid represent a kind of stress hormone that suppressed the normal immune response by blockade T-Helper 1 cell program that has function to produce gamma interferon. Glucocorticoid could give some impact like losing weight, immunodeficiency, and change the differentiation of leukocyte. This fruit of nutmeg (Myristica fragrans Houtt) is a traditional plant in Maluku and contains secondary metabolite compounds that can induce the secretion of immune system (immunomodulatory). This research has a target to discover the number of mice leukocyte and its various cell that will be induced by stress itself and will be given ethanol extract of nutmeg seed. This research considers as pure experimental with posttest only control group design. 30 mice divided into 5 different groups, which are normal control (KN), negative control (stress), positive control (stress+0.2 Alprazolam), ethanol extract of nutmeg seed 4% (P1) and 16% (P2). Group control of K-, K+, P1, P2 were stress inducted using FST method for 6 minutes, and then give orally all the treatment for 7 days long and at the 8th days the blood collected intracardially. The counting process held as manual observation. The data analyzed by using ANOVA. The result of this research shows that P1 on the experiment could decrease the presentation of neutrophil, increase the presentation of monocyte and lymphocyte, meanwhile on P2 could decrease the presentation of neutrophil and monocyte, increase the presentation of lymphocyte and has no effect to the percentation of eosinophil and basophil. We can conclude that the giving of ethanol extract of nutmeg seed didn’t give a specific effect to the average mount of neutrophil, monocyte, lymphocyte, eosinophil, and basophil (p>0.05).
PENGARUH STRES AKUT TERHADAP KADAR GULA DARAH MENCIT (Mus Musculus) DENGAN PERLAKUAN EKSTRAK ETANOL ALGA COKELAT (Sargassum sp.) Christy Sahetapy; Indrawanti Kusadhiani; Yuniasih M. J. Taihuttu; Jansye C. Penturi; Johan B. Bension; Vina Z. Latuconsina
PAMERI Vol 3 No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.93 KB) | DOI: 10.30598/pamerivol3issue2page26-42

Abstract

Stress is a non-specific response in the body to conditions or conditions that occur as a result of exposure to stressors. High stress usually has a negative impact on the body, one of which is increasing blood sugar levels. Brown algae is one of the traditional marine plants and contains secondary metabolite compounds such as alkaloids, flavonoids, and steroids which are antidepressants so that they can prevent the increase in blood sugar levels. This study aims to determine the effect of acute stress on blood sugar levels of mice by giving ethanol extract of brown algae. This research is a true experimental research design with pre test and post test control group design. 30 mice were divided into normal control (KN), negative control (K-), positive control (K +) groups, ethanol extract of brown algae with a concentration of 2.5% (P1) and 5% (P2). The study was started by measuring the initial blood sugar levels in all groups, then groups K-, K +, P1, and P2 were given stress treatment with the FST method for 6 minutes for 7 days. Group K + was given alprazolam at a dose of 0.2 ml at 1 hour before treatment, while P1 and P2 were given brown algae at 30 minutes before treatment. After the treatment, it was followed by measurement of the final blood sugar level. The data from the observations were analyzed using the dependent T-test with a confidence level of 95%. The results showed that the post-test blood sugar levels in the P1 and P2 groups experienced an increase, but the increase was not significant. The results also showed that the significance values (2-tailed) in the P1 and P2 groups were 0.772 and 0.392 (sig> 0.05), meaning that it could be concluded that there was no effect of giving ethanol extract of brown algae on the prevention of increasing blood sugar levels after acute stress.
Co-Authors Amanda Gracia Manuputty Christiana R. Titaley Christy Sahetapy Fadhila Nuralifa Fairus Indrawanti Kusadhiani Jansye C. Penturi Johan B. Bension Laura B. S. Huwae Maxwell Landri Vers Malakauseya Parningotan Y. Silalahi Vina Z. Latuconsina Zulhaimi Hendrajid