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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Rustham Basyar, Rustham
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Health Professions Medicine & Pharmacology Public Health

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p53 Gene Codon 72 Polymorphisms among Cervical Carcinoma Patients Basyar, Rustham; Saleh, Agustria Z; Sastradinata, Irawan; Yuwono, Yuwono
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 3, July 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.277 KB) | DOI: 10.32771/inajog.v3i3.48

Abstract

Objective: To identify the association between p53 gene codon 72 polymorphism and cervical carcinoma. Method: An analytic observational study with case-control design, from November 2013 until March 2014 in the Department of Obstetrics and Gynecology and Microbiology Laboratory Faculty of Medicine, Sriwijaya University, Dr. Moh. Hoesin Hospital Palembang. Result: In total there are 100 samples analyzed consisting of 50 subjects and 50 control groups. Genotype distribution in subject group are 54% Arg/Arg, 42% Pro/Arg and 4% Pro/Pro, and in control group are 36% Arg/Arg, 46% Pro/Arg and 18% Pro/Pro. Arg/Arg genotype is at risk of cervical carcinoma 6.7 times higher compared with Pro/Pro genotype (p=0.013; OR 6.75; 95% CI 1.34-34.94). Arg allele in the p53 gene codon 72 increase the risk of cervical carcinoma 2.6 times more than Pro allele. Conclusion: Proline mutation to Arginine in gene p53 P72R is one of the risk factor for cervical carcinoma. Keywords: arginine, cervical carcinoma, gene p53 codon 72, polymorphism, proline
p53 Gene Codon 72 Polymorphisms among Cervical Carcinoma Patients Basyar, Rustham; Saleh, Agustria Z; Sastradinata, Irawan; Yuwono, Yuwono
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 3, July 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.277 KB) | DOI: 10.32771/inajog.v3i3.48

Abstract

Objective: To identify the association between p53 gene codon 72 polymorphism and cervical carcinoma. Method: An analytic observational study with case-control design, from November 2013 until March 2014 in the Department of Obstetrics and Gynecology and Microbiology Laboratory Faculty of Medicine, Sriwijaya University, Dr. Moh. Hoesin Hospital Palembang. Result: In total there are 100 samples analyzed consisting of 50 subjects and 50 control groups. Genotype distribution in subject group are 54% Arg/Arg, 42% Pro/Arg and 4% Pro/Pro, and in control group are 36% Arg/Arg, 46% Pro/Arg and 18% Pro/Pro. Arg/Arg genotype is at risk of cervical carcinoma 6.7 times higher compared with Pro/Pro genotype (p=0.013; OR 6.75; 95% CI 1.34-34.94). Arg allele in the p53 gene codon 72 increase the risk of cervical carcinoma 2.6 times more than Pro allele. Conclusion: Proline mutation to Arginine in gene p53 P72R is one of the risk factor for cervical carcinoma. Keywords: arginine, cervical carcinoma, gene p53 codon 72, polymorphism, proline
Co-Authors Saleh, Agustria Z Sastradinata, Irawan Yuwono Yuwono