AbstrakPenanganan pandemi COVID-19 melalui vaksinasi memerlukan Vaksin COVID-19. Vaksin merupakan produk biologis yang rentan rusak sehingga memerlukan pengelolaan khusus. Penelitian ini bertujuan untuk mengevaluasi pengelolaan Vaksin COVID-19 di Dinas Kesehatan Provinsi Bali Tahun 2022. Penelitian menggunakan metode kualitatif deskriptif. Informan penelitian adalah pejabat dan staf yang terlibat dalam pengelolaan vaksin COVID-19 menggunakan instrumen yang berupa pedoman wawancara. Hasil penelitian menunjukkan bahwa pengelolaan Vaksin COVID-19 di Dinas Kesehatan Provinsi Bali Tahun 2022 yang meliputi penerimaan, penyimpanan, pendistribusian, penanganan vaksin rusak dan kadaluarsa, serta pencatatan dan pelaporannya menggunakan acuan pedoman yang ditetapkan oleh Kementrian Kesehatan. Kalibrasi alat belum dilakukan sesuai aturan pada proses penyimpanan namun secara umum proses penyimpanan sudah dilakukan sesuai standar. Berdasarkan hasil penelitian disimpulkan bahwa secara umum pengelolaan Vaksin COVID-19 di Dinas Kesehatan Provinsi Bali Tahun 2022 yang meliputi penerimaan, penyimpanan, pendistribusian, penanganan vaksin rusak dan kadaluarsa, serta pencatatan dan pelaporannya sudah sesuai standar yang ditetapkan oleh Kementrian Kesehatan.Kata kunci: Pengelolaan, Vaksin, COVID-19, Dinas Kesehatan Provinsi BaliAbstractHandling the COVID-19 pandemic through vaccination requires a COVID-19 vaccine. Vaccines are biological products that are susceptible to damage, so they require special management. This study aims to evaluate the management of the COVID-19 Vaccine at the Bali Provincial Health Office in 2022. The study used a descriptive qualitative method. Research informants are officials and staff involved in the management of the COVID-19 vaccine using an instrument in the form of an interview guide. The results showed that the management of the COVID-19 Vaccine at the Bali Provincial Health Office in 2022 which includes receiving, storing, distributing, handling damaged and expired vaccines, as well as recording and reporting using the reference guidelines set by the Ministry of Health. The instrument calibration has not been carried out according to the rules in the storage process but in general the storage process has been carried out according to standards. Based on the results of the study, it was concluded that in general the management of the COVID-19 Vaccine at the Bali Provincial Health Office in 2022 which includes receipt, storage, distribution, handling of damaged and expired vaccines, as well as recording and reporting are in accordance with the standards set by the Ministry of Health.Keywords:Management, Vaccines, COVID-19, Bali Provincial Health Office