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REVIEW ARTIKEL: ANALISIS MOLECULAR DOCKING SENYAWA GOLONGAN FLAVONOID SEBAGAI ANTIBAKTERI TERHADAP RESEPTOR PBP 2A BAKTERI MRSA: ARTICLE REVIEW: MOLECULAR DOCKING ANALYSIS OF FLAVONOID COMPOUNDS AS ANTIBACTERIALS AGAINST PBP 2A RECEPTORS OF MRSA BACTERIA Jajang Japar Sodik; Deden Indra Dinata
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.736

Methicillin-resistant Staphylococcus aureus (MRSA), bakteri yang resisten terhadap antibiotik b-laktam seperti methicillin, merupakan masalah klinis yang terus-menerus mempengaruhi seluruh dunia. Resistensi terjadi akibat adanya modifikasi struktural protein pengikat penisilin (PBP)2a bakteri MRSA. Flavonoid adalah salah satu senyawa aktif terpenting yang secara alami terdapat pada tanaman. Beberapa flavonoid telah terbukti memiliki sifat antibakteri pada penelitian sebelumnya. Penambatan molekul (Molecular Docking) merupakan salah satu metode in silico (virtual) berbasis struktur yang paling sering digunakan dan paling sederhana. Tujuan dari review jurnal untuk mengetahui senyawa turunan flavonoid pada tanaman obat yang berpotensi untuk dikembangkan sebagai pengobatan antibakteri terhadap bakteri MRSA berdasarkan dari beberapa studi secara in-silico. Metode pencarian jurnal dilakukan melalui website https://scholar.google.co.id/ dan Pubmed dengan menggunakan kata kunci Molecular Docking Flavonoid Methicillin Resistant Staphylococcus aureus. Hasil yang didapat adalah dari 31 senyawa aktif turunan flavonoid yang berpotensi menghambat reseptor PBP2a bakteri MRSA. Pada PDB ID IMWT didapatkan senyawa terbaik Diferulic acid memiliki nilai binding affinity sebesar -102.4, pada PDB ID 1VQQ didapatkan senyawa terbaik Hesperidin memiliki nilai binding affinity sebesar -9.2 dan pada PDB ID 4DKI didapatkan senyawa terbaik Quercetin 3-O-rutinoside memiliki nilai binding affinity sebesar -91.56. Kata kunci : Molecular Docking , Methicillin-resistant Staphylococcus aureus (MRSA), Flavonoid.

REVIEW ARTIKEL: ANALISIS MOLECULAR DOCKING SENYAWA GOLONGAN FLAVONOID SEBAGAI ANTIBAKTERI TERHADAP RESEPTOR PBP 2A BAKTERI MRSA: ARTICLE REVIEW: MOLECULAR DOCKING ANALYSIS OF FLAVONOID COMPOUNDS AS ANTIBACTERIALS AGAINST PBP 2A RECEPTORS OF MRSA BACTERIA Jajang Japar Sodik; Deden Indra Dinata
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.736

Methicillin-resistant Staphylococcus aureus (MRSA), bakteri yang resisten terhadap antibiotik b-laktam seperti methicillin, merupakan masalah klinis yang terus-menerus mempengaruhi seluruh dunia. Resistensi terjadi akibat adanya modifikasi struktural protein pengikat penisilin (PBP)2a bakteri MRSA. Flavonoid adalah salah satu senyawa aktif terpenting yang secara alami terdapat pada tanaman. Beberapa flavonoid telah terbukti memiliki sifat antibakteri pada penelitian sebelumnya. Penambatan molekul (Molecular Docking) merupakan salah satu metode in silico (virtual) berbasis struktur yang paling sering digunakan dan paling sederhana. Tujuan dari review jurnal untuk mengetahui senyawa turunan flavonoid pada tanaman obat yang berpotensi untuk dikembangkan sebagai pengobatan antibakteri terhadap bakteri MRSA berdasarkan dari beberapa studi secara in-silico. Metode pencarian jurnal dilakukan melalui website https://scholar.google.co.id/ dan Pubmed dengan menggunakan kata kunci Molecular Docking Flavonoid Methicillin Resistant Staphylococcus aureus. Hasil yang didapat adalah dari 31 senyawa aktif turunan flavonoid yang berpotensi menghambat reseptor PBP2a bakteri MRSA. Pada PDB ID IMWT didapatkan senyawa terbaik Diferulic acid memiliki nilai binding affinity sebesar -102.4, pada PDB ID 1VQQ didapatkan senyawa terbaik Hesperidin memiliki nilai binding affinity sebesar -9.2 dan pada PDB ID 4DKI didapatkan senyawa terbaik Quercetin 3-O-rutinoside memiliki nilai binding affinity sebesar -91.56. Kata kunci : Molecular Docking , Methicillin-resistant Staphylococcus aureus (MRSA), Flavonoid.

COMPARISON OF ANALYSIS METHODS FOR CURCUMIN DETERMINATION: A LITERATURE REVIEW Jajang Japar Sodik; Deden Indra Dinata; R. Herni Kusriani; Garnadi Jafar
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.850

Curcuminoids such as curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) are the major bioactive components found in Curcuma species, including turmeric (Curcuma longa L.). Curcumin is a polyphenol that is used as an antioxidant. Various analytical methods have been developed for the detection of curcumin, each with its advantages and limitations. Selection of an appropriate analytical method is crucial for obtaining accurate results. Although critical reviews on the chemical, biological, and pharmacological properties of curcumin are widely available, reviews specifically focusing on the different analytical methods for curcumin are limited. This review article aims to provide an overview of several analytical methods for the determination of curcumin. This is expected to encourage readers to choose a suitable analytical method for their specific needs. The articles used in this review were sourced from international English-language publications obtained from Science Direct, PubMed, and Google Scholar. The search was performed using keywords such as "Instrumental analysis of curcumin" and "Analytical techniques for curcumin analysis." The results reveal that spectrophotometric methods are simple techniques used to estimate curcumin content; however, their utility is limited to cases where the concentration of each curcuminoid is not a critical quality parameter. Accurate quantification and detection of trace amounts of curcuminoids and metabolites require the use of chromatographic separation methods combined with mass spectrometry detection (LC-MS/MS) because of their high accuracy, reproducibility, and sensitivity with low limits of detection (LOD) and lower limits of quantification (LLOQ). Keywords: Analytical methods, Curcumin, Determination

REVIEW: THE POTENTIAL OF HERBAL PLANTS AS ANTI-ALOPECIA MEDICINES Arif Rubianto; Garnadi Jafar; Deden Indra Dinata; Jajang Japar Sodik
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1204

Hair loss, or alopecia, is a common dermatological condition that affects up to 2% of the world's population. It is often caused by genetic factors, such as male or female pattern baldness, but can also be attributed to various environmental factors, an imbalanced diet, or chronic illnesses. While hair loss is not life-threatening, it can lead to significant anxiety, depression, and other psychological issues, ultimately affecting one's quality of life. Various treatments for baldness, including synthetic drugs like minoxidil and finasteride, or herbal remedies, have been approved by the Food and Drug Administration. Although synthetic drugs are effective, they may come with potential side effects. Natural remedies have been proposed as a viable option for treating baldness because many chronic disorders can lead to alopecia. Therefore, this review focuses on identifying efficient alternative treatment agents with limited side effects. Specifically, it considers medicinal plants as potential healing agents for treating baldness. To gather relevant information for this study, several databases were searched, including Scopus, PubMed, and Google Scholar. Comprehensive searches were conducted using various search terms, such as "baldness," "alopecia," "natural remedies for baldness," "herbal treatment for baldness," and others, to extract relevant scientific articles. Many medicinal plants and natural compounds have shown potential for reducing baldness, thanks to their anti-inflammatory and antioxidant properties. According to existing literature, extracts of medicinal plants and formulations derived from plants, such as Eclipta alba (L.) Hassk, Arctium lappa L., Centella asiatica L., Morinda citrifolia, Acorus calamus var. angustatus, Alpinia zerumbet, ...

POTENTIAL ANTIOXIDANT ACTIVITY OF SURUHAN LEAF AND STEM EXTRACT (Peperomia pellucida L. Kunth) USING THE DPPH METHOD AND DETERMINATION OF PHENOLIC AND FLAVONOID LEVELS Jajang Japar Sodik; Wempi Budiana; Asep Roni; Wahyudin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024): Forthcoming Issue
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1264

Antioxidants are compounds that are capable of neutralizing free radicals. One plant with potential antioxidant properties is Peperomia pellucida. Objective: This study aimed to determine the antioxidant activity, total phenolic content, and total flavonoid content of extracts of the leaves and stems of Peperomia pellucida. Methods: Antioxidant activity was tested using the DPPH method, while the total phenolic and flavonoid contents were measured using UV-Vis spectrophotometry. Extraction was performed via reflux using three different solvents: n-hexane, ethyl acetate, and ethanol. Results: The highest antioxidant activity was found in the ethanol extract of the leaves, with an IC50 value of 36.85 µg/mL, and in the stems, with an IC50 value of 71.28 µg/mL. The highest total phenolic content in the ethanol extract of the leaves was 14.46 mg GAE/g and that in the stems was 12.82 mg GAE/g. The highest total flavonoid content in the ethanol extract of the leaves was 12.12 mg QE/g and that in the stems was 10.49 mg QE/g. Conclusion: The results indicated that the ethanol extract of Peperomia pellucida leaves exhibited very strong antioxidant activity. Keywords: antioxidants, DPPH, phenolic, flavonoids, suruhan Plants

Bersama Desa Mangunarga: Membangun Perilaku Hidup Bersih dan Sehat untuk Kehidupan Sejahtera Mamay Maulana Sobandi; Yakobus Lau De Yung Sinaga; Roganda Situmorang; Isviyanti Isviyanti; Jajang Japar Sodik
Ekspresi : Publikasi Kegiatan Pengabdian Indonesia Vol. 1 No. 3 (2024): Juli: Ekspresi : Publikasi Kegiatan Pengabdian Indonesia
Publisher : Asosiasi Seni Desain dan Komunikasi Visual Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/ekspresi.v1i3.213

Waste management remains a major challenge in Indonesia, particularly concerning marine plastic waste and the increase in hazardous waste (B3). The lack of understanding and limited facilities such as TPS-3R and waste banks further exacerbate the situation. In response, we conducted a community service program in Mangunarga Village, Sumedang, West Java, aimed at raising awareness and improving waste management practices. This program included educational workshops and equipping waste processing facilities. The results showed a significant increase in community understanding and behavior related to waste management, with awareness rising from 16.5% to 97.2%, and proper waste sorting practices increasing from 8.2% to 96.3%. The success of this program underscores the importance of community-based approaches and supportive infrastructure in addressing environmental challenges at the local level.

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