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UPAYA MENINGKATKAN KEMAMPUAN ANAK DALAM MEMBILANG DENGAN MENGGUNAKAN MEDIA BENDA Harmita, Harmita
Jurnal Pendidikan Tambusai Vol. 3 No. 3 (2019): December 2019
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Media yang dipilih guru dalam proses belajar mengajar sangat menentukan keberhasilan pemahaman materi. Media yang beragam dapat menimbulkan motivasi dan semangat belajar bagi anak. Media yang digunakan dan cara penyajian yang menarik dapat menimbulkan daya tarik tersendiri bagi anak. Keingintahuan anak sangat besar jika ia melihat media yang menarik. Hal ini dapat meningkatkan kemampuan belajar anak. Berdasarkan deskripsi siklus I dan siklus ke II refleksi dapat disimpulkan bahwa hampir semua masalah dapat diatasi dengan meningkatkan kompetensi mengajar. Hal ini dapat kita lihat dengan hasil pencapaian kemampuan anak. Pada siklus I dan II ditetapkan nilai ketuntasan yang berbeda, namun pada akhir kegiatan perbaikan ke V di siklus II nilai yang diperoleh melebihi nilai ketuntasan yang ditetapkan yaitu 90%. Sedangkan nilai ketuntasan ditargetkan 85%.

Optimasi Penetapan Kadar Akrilamida Yang Ditambahkan Ke Dalam Keripik Kentang Simulasi Secara Kromatografi Cair Kinerja Tinggi Harahap, Yahdiana; Harmita, Harmita; Simanjuntak, Binsar
Majalah Ilmu Kefarmasian Vol. 2, No. 3
Publisher : UI Scholars Hub

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A method by high performance liquid chromatography for the analysis of acrylamide in potato chips, is reported. The retention time for the elution of acrylamide from the C18RP column ranged from 3 to 3,2 minutes, and the eluate was analyzed by UV-VIS detector. A linear response was found for the acrylamide standard tested within the concentration range of 0,8 Â– 10Âµg/ml and the corelation coefficient (r) greater than 0,999, with detection limit 0,06 ppm and quantitative limit 0,19 ppm. Sample preparation was performed by means of solvent extraction using dichlormethane and subsequent re-extraction of the organic solvent with water. This aqueous sample solution was found to be free of any interferences and gave acrylamide and recorveries higher than 90%.

Amankah Pengawet Makanan Bagi Manusia ? Harmita, Harmita
Majalah Ilmu Kefarmasian Vol. 3, No. 1
Publisher : UI Scholars Hub

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Determination of Ethanol In Employee's Blood Who Work In "X" Alcoholic Beverage Industry Using 1-Propanol as an Internal Standard by Gas Chromatography Harmita, Harmita; Mansur, Umar; Rahmadani, Suchi
Majalah Ilmu Kefarmasian Vol. 4, No. 3
Publisher : UI Scholars Hub

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Ethanol not only caused drunk, but also in certain amount it can caused death. Because of the side effect of ethanol was dangerous if there sufficient concentration in blood and the penetration which is relatively easy so it was important to know how much ethanol in blood, especially on official employee in alcoholic beverage industry. A gas chromatography method using a capillary column CBP-10 and flame ionization detector (FID) has been developed and validated for the detection and quatification of ethanol in blood. Gas chromatography was performed in isothermal mode with column temperature 60oC. Helium was used as carrier gas with flow rate 1.0 mL/min. Quantification was performed with the uses of 1-propanol as an internal standard (IS). The method was linear in the concentration range of 0.001-0.8% v/v with coefficient of corelation 0.9998. The lower limit of quantification (LLOQ) was found to be 0.001% v/v. This method was validated with precisions (CV) 0.53-3.47% and accuracies (% diff) 3.86-7.46%. Result of ethanol recovery varied from 96.14-107.46%. The result of validation method fulfilled for the given criteria.

Analisis Asam Valproat dalam Plasma Secara Kromatografi Gas Susanti, Ani; Harahap, Yahdiana; Harmita, Harmita
Majalah Ilmu Kefarmasian
Publisher : UI Scholars Hub

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Valproic acid is an anticonvulsant drug that works by increasing the levels of γ-aminobutyric acid (GABA). Determination of valproic acid is quite difficult because it has no chromophore groups in its structure. Aa analytical method using gas chromatography (GC) with flame ionization detector for the determination of valproic acid in human plasma has been developed and optimized. Valproic acid was extracted from plasma by liquid-liquid extraction method using diethyl ether. The optimum analysis conditions for valproic acid in plasma were achieved by regulated gas chromatography injector and detector at a temperature of 250oC and temperature programming with an initial temperature of 70oC and 5oC temperature increasing per minute until a temperature of 100oC, then held for 1 minute. Then the temperature was increased by 2°C per minute until the column temperature to 150oC. The optimum conditions of analysis took 32 minutes. In the concentration range from 40.0 to 100.0 µg/mL yielded a linear calibration curve with correlation coefficient (r) of 0.9894. Accuracy (% diff) of this method was -13.67% to 12.33% with precision (CV) between 9.33% to 14.92%, and relative recovery test was 86.33% to 112.33%.

Optimasi Biotransformasi Total Sterol Limbah Tahu Menggunakan Mycobacterium phlei DSM 43286 Menjadi 1,4-Androstadien-3,17-Dion, Dengan Pengaruh Variasi Konsentrasi Inhibitor A, A’- Dipiridil Kurniadi, Maryati; Tambunan, Usman Sumo Friend; Harmita, Harmita
Majalah Ilmu Kefarmasian Vol. 1, No. 1
Publisher : UI Scholars Hub

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Isolation of total sterol from waste product of soy bean cake has been conducted, followed by biotransformation to 1,4-androstadien-3,17-dione (ADD). The waste product consist of; β-sitosterol, stigmasterol, kaemfesterol, which are isolated by column chromatography technique using silica gel as stationary phase and chloroform as mobile phase. Biotransformation was conducted by using Mycobacterium phlei DSM 43286 in the present of α, α’- dipiridil as an inhibitor with concentration of 0,5; 1; 1,5; 2,0 mM. The main product of biotransformation were ADD and pregnenolon. The optimum yield of ADD 0,48% is achieved by adding 1,5 mM α, α’- dipiridil are two hours after addition of substrate and 72 hours of incubation time.

Metode Penetapan Kadar Meloxicam Dalam Darah Manusia In Vitro Secara Kromatografi Cair Kinerja Tinggi Harmita, Harmita; Mansur, Umar; Firnando, Firnando
Majalah Ilmu Kefarmasian Vol. 1, No. 2
Publisher : UI Scholars Hub

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Until nowadays study of drug profile inside body (pharmacokinetic) and its development is still an interesting topic under pharmaceutical service. Development of an accurate analysis method for small quantity of drug in blood is an important step, HPLC method usually recommended for this purpose. Observation in studying the optimal method to analyze drug in human blood by using internal standard has been done for meloxicam, a new generation of NSAID. Two things has been focused to this observation, finding an ideal internal standard for meloxicam and testing the recovery of meloxicam in blood sample by in vitro. Coefficient of distribution of many samples (piroxicam, trimetropim, caffeine, salisilamid) gives caffeine as recommended internal standard for meloxicam. The recovery test gives 83,58% Â± 3,802%, 74,37% Â± 0,711%, 82,14% Â± 1,937% for analysis meloxicam in human blood without internal standard; and 41,58% Â± 1,108%, 61,60% Â± 1,049%, 56,88% Â± 0,478% for analysis meloxicam in human blood within internal standard.

Petunjuk Pelaksanaan Validasi Metode Dan Cara Perhitungannya Harmita, Harmita
Majalah Ilmu Kefarmasian
Publisher : UI Scholars Hub

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Each analysis method by some reason, must be validated. The parameters are selectivity, accuracy, precision, linearity, LOD, LOQ, ruggedness, and robustness. The parameters need to be calculated by assay methods. This paper try to give some information above these methods base on some literatures (USP 23rd, WHO, journal, etc).

Karakterisasi Gelatin Hasil Ekstraksi dari Kulit Ikan Patin (Pangasius hypophthalmus) dengan Proses Asam dan Basa Nasution, Azlaini Yus; Harmita, Harmita; Harahap, Yahdiana
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Gelatin in the majority market comes from pigs and cows. The raw material of gelatin manufacture from other sources continue to be studied because it closely related with halal product. Currently gelatin from fish is an alternative to gelatin making. Catfish (Pangasius hypophthalmus) is a fish species developed in Kampar regency of Riau Province. The catfish skin can be used as raw material source in gelatin production. This study aims to compare the characteristics of gelatin extracted from catfish skin with acid and alkaline pretreatment. In the acid pretreatment, sulfuric acid is used until the solution at pH 3, then it is extracted with distilled water at 60ºC. In the alkaline pretreatment, the sample was added by 0.2 N NaOH followed by 0.05 N acetic acid and then extracted with distilled water at 60ºC. Characterizations done were including calculation of rendement value, organoleptic test, moisture content, pH, ash content, viscosity, gel strength and texture profile analysis using texture analyzer, protein content with Kjeldahl method and analysis amino acid with HPLC. Characterization of catfish gelatin with acid process gives the following results: rendement (14.94%), water content (9.80%), pH (5.14), ash (0.19%), viscosity (3.12 cP), protein content (97.71%), and highest amino acids, glycine = 16.90 %, proline = 11.08%, glutamic acid = 9.10 %. The result of gelatin characterizations with alkaline process: rendement (14.30%), water content (7.25%), and pH (5.35), ash content (1.54%), viscosity (5.35 cP), gel strength (141,5 g), protein content (91.92%), the highest amino acid content are glycine = 18.15%, proline = 12.30%, glutamic acid = 10.73%. Catfish gelatin through alkaline pretreatment exhibits better properties than acid pretreatment.

Pengembangan Metode Analisis Agen Pengatur Keasaman Pakan Ternak Menggunakan Metode Kromatografi Cair Kinerja Tinggi Asih, Ninis Kurnia; Harmita, Harmita; Maggadani, Baitha Palanggatan
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Quantitative analysis of organic acid in acidifier product is needed to maintain product effectiveness in repressing microbial growth and lowering feed and gastrointestinal tract pH. The aim of this research is determining the level of formic and lactic acid in two acidifiers from the market. Analysis were performed using reversed phase High Performance Liquid Chromatography (HPLC) with LiChrospher® 100 RP-18 column (250 x 4.0 mm, 5μm, Merck), buffer potassium dihydrogenphosphate 50 mM-TEA 0,5% pH 4,00 as mobile phase and flow rate 0,6 mL/min. Wavelength used in the analysis was 214 nm. Validation methods provide results of recovery by 98.02%-101.97% for formic acid and 97.09%-102.78% for lactic acid, RSD <0.59% for formic acid and 1.28% for lactic acid, LOD 63.05 µg/mL for formic acid 4.55 µg/mL for lactic acid, LOQ 210.16 µg/mL for formic acid and LOD 15.18 µg/mL for lactic acid. The analysis method gives linearity in the range of 439.2 -1764.61 µg/mL for formic acid with correlation coefficient (r) 0.9992 while lactic acid linearity range was 47.88 µg/mL-193.44 g/mL with a correlation coefficient (r) 0.9994. Conformity product A to its label provides the results of 108.19%-109.82% formic acid and 156.88%-167.90% lactic acid whereas the result for product B were 101.65%-109.95% formic acid and 151.10%-172.82% lactic acid.

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