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Muharni Saputri
Fakultas Farmasi, Universitas Tjut Nyak Dhien, Medan, Sumatera Utara, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Formulasi Sediaan Ekstrak Etanol Kulit Buah Alpukat (Persea Americana Mill.) Sebagai Krim Alas Bedak Hamdhani Hamdhani; Muharni Saputri; Sudewi Sudewi; Linda Margata
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.588 KB) | DOI: 10.36490/journal-jps.com.v6i2.49

Abstract

Background; Avocado (Persea americana Mill.) is a plant that is widely grown in Indonesia. Peel avocado is known to contain secondary metabolites such as flavonoids which are useful as antioxidants. This study aims to determine the peel of avocado (Persea americana Mill.) in the form of ethanol extract can be formulated into a foundation cream preparation which at a certain concentration has antioxidant activity. Method; The study was conducted using an experimental method, using peel avocado test material (Persea americana Mill.) processed by maceration using 96% ethanol extract formulated into a foundation cream preparation in a concentration of 1.5%; 2%; 2.5%; and blank. Examination of the physical quality of the preparation includes homogeneity test, pH test, viscosity test, stability test, irritation test, moisture test and antioxidant activity test. Result; The results showed that the yield of peel avocado (Persea americana Mill.) was 12.99%. All formulations met the requirements of the gel evaluation test with a pH range of 6.0-6.5. After doing the cycling test, it was 5.9-6.2. The viscosity results are 15,250-20,050 mPa.S. All formulations are homogeneous and stable. Formulation 3 has an IC50 value of (54.74µg/mL) in the "strong" antioxidant category and has a % recovery value of 67.23%.
Formulasi Dan Uji Efektivitas Sediaan Salep Ekstrak Etanol Daun Sintrong (Crassocephalum crepidioides (Benth.) S.Moore) Terhadap Penyembuhan Luka Bakar Pada Marmut Jantan (Cavia porcellus) Muharni Saputri; Yessi Febriani; Olyvia putri Olyvia putri
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.337 KB) | DOI: 10.36490/journal-jps.com.v6i2.52

Abstract

Background; Scar tissue formation due to infectious burns causes delayed maturation of the epidermis. Sintrong contains flavonoids, alkaloids, glycosides, saponins, tannins, and steroids which have anti-inflammatory and antioxidant functions and can protect the body from the harmful effects of free radicals. Preparations with good titration and long exposure times are needed to treat burn problems. This study aims to determine the process of making sintrong leaf ointment (Crassocephalum crepidiodes (Benth.) S.Moore) and the effect of treating burns from sintrong leaf extract in an ointment preparation that has been tested on male guinea pigs (Cavia porcellus). Methods; In this study, test methods were used by means of simplicia preparation, characterization, test phytochemical screening, extraction, formulation and adjustment of ointment preparations to concentrations of 0.5%, 1% and 1.5%, as well as evaluation of ointment tests which included stability tests, sensory tests, homogeneity tests,adhesion, spreadability, pH test, irritation test and efficacy test of ointment preparations. The results obtained from the characteristic examination indicate that the simplicia of the sintrong leaf has fulfilled the requirements of the characteristic test for simplicia. Result; The results of the phytochemical test showed that the positive sintrong leaves contained alkaloids, flavonoids, glycosides, saponins, tannins and triterpenes or steroids. The results of the evaluation of the ethanol extract of sintrong leaf ointment for stable results. The best formulation is formula 3 with a concentration of 1.5% with a wound healing diameter of 0.13 cm on the 21st day
Efek pemberian ekstrak etanol daun sintrong (Crassocephalum crepidioidies) terhadap penurunan berat badan tikus jantan Muharni Saputri; Salmah Handayani Lubis; Fenny Hasanah; Siti Muliani Julianty; Muflihah Fujiko; Ernawaty Ginting; Anggi Salsabilah Nasution; Kiki Mariana Batubara
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.213

Abstract

One of the medicinal plants that has the effect of reducing obesity is the sintrong plant. This plant has tannins, saponins, polyphenols, and flavonoids so that it can reduce blood glucose levels as an antidiabetic effect and can reduce weight. The purpose of this study was to see the occurrence of weight loss in test animals by administering ethanol extract of sintrong leaves and to find out whether the different doses of sintrong leaves can reduce body weight in male white rats. The research method was carried out experimentally, then testing the effectiveness of the ethanol extract of sintrong leaves using 25 rats which were divided into groups I to V with varying doses of 250 mg, 500 mg, and 750 mg, and carried out statistically by the Tukey method. The results of this acquisition when compared with the comparison group are not much different. Based on the result obtained, group V was given a suspension of ethanol extract of sintrong leaves at a dose of 750 mg/kgBW and the comparison group was given orlistat haven’t significant difference based on a statistical test with α > 0.05 so it could be concluded that there was a decrease in body weight in rats after administration of ethanol extract of sintrong leaves at a dose of 750mg/kgBW.
Co-Authors Anggi Salsabilah Nasution Ernawaty Ginting Hamdhani Hamdhani Kiki Mariana Batubara Linda Margata Muflihah Fujiko Olyvia putri Olyvia putri Salmah Handayani Lubis Siti Muliani Julianty Sudewi Sudewi Yessi Febriani