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All Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Penyakit Dalam Indonesia
Nur Riviati, Nur
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Role of IL-6 and IGF-1 in sarcopenia Riviati, Nur; Legiran, Legiran; Indrajaya, Taufik; Saleh, Irsan
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 1: March 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2023.303 KB) | DOI: 10.30604/jika.v8i1.1625

Abstract

Background: Sarcopenia is a syndrome characterized by decreased muscle mass and decreased muscle strength and muscle function. Oxidative stress and inflammatory processes are known to contribute to sarcopenia by releasing the catabolic stimuli interleukin-6 (IL-6) and insulin-like growth factor (IGF). Methods: The method used is a literature review by collecting appropriate articles from the PubMed and Google Scholar databases. Results: Low IL-6 can trigger satellite cell activity and myotube regeneration, whereas if IL-6 production increases chronically, it triggers muscle wasting. Changes in muscle size are the result of changes in the synthesis and degradation of muscle protein. IGF-1, where signal changes are strongly related to muscle size. IGF-1 binding to the receptor causes intracellular phosphorylation of the adapter protein Shc or insulin receptor substrate (IRS-1). Conclusion: The role of IGF-1 and IL-6 can be helpful as diagnostic and prognostic parameters for sarcopenia. Abstrak: Latar belakang: Sarkopenia adalah sindrom yang ditandai dengan penurunan massa otot disertai penurunan kekuatan otot dan atau fungsi otot. Stres oksidatif dan proses inflamasi dikenal sebagai faktor pemicu untuk sarkopenia dengan melepaskan rangsangan katabolik interleukin-6 (IL-6) dan IGF1. Metode: Metode yang digunakan adalah literature review dengan mengumpulkan artikel-artikel yang sesuai dari data base PubMed dan google sholar. Hasil: IL-6 yang rendah dapat mencetuskan aktivitas sel-sel satelit dan regenerasi myotube, sedangkan bila produksi IL-6 meningkat secara kronik mencetuskan muscle wasting. Perubahan ukuran otot merupakan dampak dari perubahan sintesis dan degradasi protein otot. IGF-1 dimana perubahan sinyal berhubungan kuat dengan ukuran otot. Ikatan IGF-1 pada reseptor menyebabkan fosforilasi intracellular adaptor proteins Shc atau insulin receptor substrate (IRS-1). Kesimpulan: Peran IGF-1 dan IL-6 dapat berguna sebagai parameter diagnostik dan prognostic terhadap kejadian sarcopenia.
The Role of Albumin and Hemoglobin as Predictors of 28-day Mortality in Elderly Sepsis Patients in Mohammad Hoesin Hospital Palembang Gultom, Widya Mandala Sari; Riviati, Nur; Perdana, Rizky; Husin, Syarif
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 3
Publisher : UI Scholars Hub

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Abstract

Introduction. Sepsis is defined as organ dysfunction caused by dysregulation of the host’s response to infection. The majority of sepsis are experienced by elderly patients with high mortality rates. In the condition of sepsis, there are various body mechanisms that cause a decrease in albumin and hemoglobin. This study is to determine the predictive value of albumin and hemoglobin levels on 28-day mortality of elderly sepsis patients.
Correlation between Polypharmacy and Length of Stay Geriatric Patient in Mohammad Hoesin Palembang Hospital Tanzil, Iswadi; Riviati, Nur; Saleh, Irsan
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 4
Publisher : UI Scholars Hub

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Introduction. Geriatric patients have multipathological characteristics, low physiologic reserves, atypical clinical signs and symptoms, decreased functional status, and nutritional disturbances. This situation is a risk factor for polypharmacy. Polypharmacy is closely related to drug side effects, drug interactions, and patient compliance. Polypharmacy is thought to have a relationship with the length of stay in geriatric patients. The purpose of this study was to determine the correlation between polypharmacy and length of stay in geriatric patients at Moehammad Hoesin Hospital Palembang. Methods. This was a cross-sectional study with a correlation test design conducted at Dr. Mohammad Hoesin Hospital (RSMH) Palembang from April 2021 to July 2021. The sample was geriatric patients aged > 60 years. We collected data on the number and types of drugs given and the length of hospitalization. All data processing and analysis in this study were conducted by using SPSS version 22 for Windows. Results. Of 56 geriatric patients, there was 28 female (50%) and 28 male (50%). The median value of the number of drugs was 7 (3-32). Patients without polypharmacy were 7 (12.5%), and patients with polypharmacy were 49 (87%). The median length of hospitalization for geriatric patients at RSMH was 11.5 (range 1-47) days. There was a correlation between polypharmacy and length of stay (r=0.277; p value=0.039). Conclusion. There is a weak correlation between polypharmacy and length of stay (r=0.277; p=0.039).
Co-Authors Gultom, Widya Mandala Sari Indrajaya, Taufik Legiran Legiran Muhammad Irsan Saleh Murdani Abdullah Perdana, Rizky Purwita W Laksmi, Purwita W Siti Setiati Syarif Husin Tanzil, Iswadi