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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journal of Islamic Medicine MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Biomolecular and Health Science Journal Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Implementa Husada
Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu
Faculty Of Medicine Universitas Muhammadiyah Surabaya, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Dilema Penggunaan Aspirin dan Proton Pump Inhibitor (PPI) Pada Pasien Gastroesophageal Reflux Disease Dengan Coronary Artery Disease (CAD) Prahastutik, Rizkia Hani; Airlangga, Muhammad Perdana; Ayu Rezkitha, Yudith Annisa; Irawati, Detti Nur
Journal of Islamic Medicine Vol 5, No 1 (2021): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2021
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v5i1.11572

Abstract

Latar belakang: Gastroesofageal Reflux Disease (GERD) ini sering terjadi pada penderita Coronary Artery Disease (CAD) dengan keluhan nyeri dada. Oleh karena itu obat antiplatelet digabungkan dengan Proton Pump Inhibitor (PPI) untuk pencegahan dari efek samping aspirin dan pengobatan GERD itu sendiri. Karena efek samping pendarahan gastrointestinal yang disebabkan oleh aspirin, Proton Pump Inhibitors (PPI) juga bisa berpengaruh mengurangi ketersediaan hayati aspirin, sehingga mengurangi kerja aspirin. Tujuan : untuk menganalisis munculnya dilema pengobatan pada pasien Gastroesophageal Reflux Disease (GERD) dengan Coronary Artery Disease (CAD). Metode: Artikel-artikel ilmiah terpublikasi tentang Gastroesophageal Refluks Disease (GERD) dengan Coronary Artery Disease (CAD) dicari menggunakan kata kunci Gastroesophageal Reflux Disease, Coronary Artery Disease, Antiplatelet, Proton Pump Inhibitors. dengan mendapatkan jumlah artikel sebanyak 1144877 dan telah melalui skrining sesuai dengan kriteria inlusi menjadi 7 jurnal Hasil : Pada pasien kunci Gastroesophageal Reflux Disease (GERD) dengan Coronary Artery Disease (CAD) Proton Pump Inhibitors (PPIs) sering dikombinasikan dengan antiplatelet yang telah terbukti secara efektif mengurangi resiko komplikasi pada gastrointestinal pada pasien. Namun, pada beberapa penelitian pemberian PPI akan mengurangi efek kemanjuran dari antiplatelet aspirin Kesimpulan: Penggunaan PPI pada GERD dianjurkan untuk digunakan dalam jangka pendek,karena penggunaan jangka panjang pada PPI meningkatkan resiko infark miokard, gagal ginjal, dan demensia. Pertimbangan pada resiko dan manfaat dengan mengkaji faktor resiko dari ganstrointestinal perlu diperhatikanKata kunci : Antiplatelet, Coronary Artery Disease, Gastroesophageal Proton Pump Inhibitors Reflux Disease,
The effectiveness of classic lecture and workshop as interventions to improve primary health care providers knowledge and skill on the management of pediatric emergencies: a case study Ricky Indra Alfaray; Rahmat Sayyid Zharfan; Yudhistira Pradnyan Kloping; Yudith Annisa Ayu Rezkitha; Rafiqy Sa’adiy Faizun; Saruuljavkhlan Batsaikhan; Ahmad Siddiq Muhajir; Bestya Presidiana; Umaimah Rosyidah; Khodijah Nidaul Chasanah; Delia Nur Aini; Naufal Fauzy; Kamal Musthofa; Nur Firdaos; Samsriyaningsih Handayani
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.4757

Abstract

Abstract A preliminary study showed that most health workers in primary health care (PHC) claimed that they need a refreshing course because of their lack of updated knowledge and skill. This study enrolled 27 primary healthcare workers recruited from the PHC. The intervention used were classic lectures and workshops. The knowledge was evaluated using a paper-based test and practice, while the skill was evaluated using a practice test. Multiple questions (pre-test and post-test) based on current emergency management for pediatric were used for paper-based evaluation. Semi-structured interviews were conducted to confirm the subject's perspective on the intervention. A paired t-test was used for evaluating the pre- and post-test results, which was confirmed by a triangulation approach. There was a significant difference between the pre- and post-test results (p<0.001), and 8 of 10 subjects can demonstrate the procedure learned correctly after the intervention. A total of 14 interviewed subjects stated great effectiveness of the intervention, with several limitations on applicability in daily clinical practice. Classic lecture and workshop as an intervention in health education effectively increase health workers' knowledge and skill in PHC. This study might help other rural areas PHC apply the same method so the professionalism and quality of health workers in PHC providers can be maintained.Keywords                : primary health care, classic lecture; workshop; knowledge; skillCorrespondence     : rickyindraalfaray@gmail.com
Wild tembelek plant (Lantana camara) as a potential bioactive natural product againts Streptococcus pyogenes in Indonesia Ricky Indra Alfaray; Rafiqy Sa&#039;adiy Faizun; Lionardy Yodianto; Saruuljavkhlan Batsaikhan; Yudith Annisa Ayu Rezkitha
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 1 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (836.258 KB) | DOI: 10.30651/jqm.v4i1.3566

Abstract

Abstract  Infectious diseases are common problems in most countries. Streptococcus pyogenes is the infectious agent that causes diseases such as pharyngitis, impetigo, toxic shock syndrome, and necrotizing fasciitis. Tembelek (Lantana camara) is a wild plant that can easily be found in every ecosystem in Indonesia whether in nature or settlements and known as a plant that has an antibacterial effect but the knowledge about its potential against Streptococcus pyogenes in this past five years remain scant. The aim of this study was to determine the potentiality of Lantana camara leaves and flowers extract against Streptococcus pyogenes. In this experimental study, in vitro using Post-test Only Control Group Designed, has been done and confirmed by the Indonesian Institute of Sciences. Lantana camara leaves and flowers extracts were obtained by maceration using ethanol. The extracts were diluted into eight concentrations and their antibacterial activity against Streptococcus pyogenes was tested using the Kirby-Bauer disc then proceeded Minimum Inhibitory Concentration (MIC) test and phytochemical assay. The data processed using SPSS software version 22. The results showed that flowers extract had the most significant inhibition zone (11.85 ± 0.119 mm) compared with the leaves extract (9.54 ± 0.07 mm) at the highest tested concentration was 640 mg/ml. The MIC of both extracts was 250 mg/ml. Flavonoids, phenolic, steroids, and saponins were found in both extracts whereas, alkaloid was found only in flowers extract. In conclusion, the Tembelek plant has an antibacterial effect against Streptococcus pyogenes. Future study is needed related to its mechanism of antibacterial effect. Keywords                : Antibacterial potential, Lantana camara; Streptococcus pyogenes
The Role of JAK2 in Myeloproliferative Diseases Diagnosis Yudith Annisa Ayu Rezkitha; S. Ugroseno Yudho Bintoro; Ami Ashariati
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (572.416 KB) | DOI: 10.20473/bhsj.v1i2.9831

Abstract

Janus Kinase 2 (JAK2) plays an important role in mediating transduction signal of hematopoiesis, including in the pathogenesis of Myeloproliferative diseases (MPD). Various studies have been carried out to identify the position of aleles in tyrosine encoding mutations. Although the effect of JAK2 mutations is still not fully understood, the discovery of these mutations might be able to differentiate the types of polycythaemia vera, essential thrombocytemia, and primary myelofibrosis with malignant abnormalities. WHO has revised the MPD diagnosis criteria following this finding. This review will discuss the role of JAK2.
CORRELATION BETWEEN KNOWLEDGE OF CITY OF RESIDENCE AND COVID19 IN SURABAYA YOUTH GENERATION Ricky Indra Alfaray; Lionardy Yodianto; Astri Dewayani; Kartika Afrida Fauzia; Dwiki Noni Armyta; Yudith Annisa Ayu Rezkitha; Reny I'tishom; Muhammad Miftahussurur
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 5 No. 1 (2021): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v5i1.2021.116-122

Abstract

COVID19 pandemic became the primer focus of health problem by the government since the case was increasing every month in 2020. The impact of this pandemic was spread quickly across many areas including Surabaya city. Youth generation often found to be a silent source of infection. Furthermore, young people behavior often ignoring health prevention policy makes the infection more easily to spread. This condition might be because of their knowledge regarding COVID19 was relatively not enough. Factor that may affect their knowledge are varies including knowledge of city of residence. This study aims to evaluate the correlation between knowledge about city of residence with youth generation knowledge of COVID19 as this factor has not yet been studied before in Indonesia. We conducted an analytical cross-sectional with an online survey for youth generation across Surabaya to understand their knowledge concerning Surabaya and COVID19. A total of 57 participants were voluntarily enrolled in this study. The result data were analyzed statistically. There is significant positive correlation between participants’ knowledge of Surabaya city with knowledge of COVID19 (r= 0.314; p= 0.017). Furthermore, knowledge of COVID19 was significantly different between youth who have better knowledge of Surabaya than lower knowledge (p= 0.021). Knowledge of Surabaya city was correlated with knowledge of COVID19. Youth who have better knowledge regarding their city of residence seem to have better knowledge of COVID19.  Knowledge concerning city of residence proven to be important in order to increase knowledge of COVID19 in youth generation.
Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus) Andre Bagaskara; Nenny Triastuti; Nurma Yuliyanasari; Yudith Annisa Ayu Rezkitha; Muhammad Anas; Ricky Indra Alfaray
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 9, No 1 (2022): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.9.1.2022.01-09

Abstract

Background:Putri Malu plants (Mimosa pudica linn) contain flavonoid compounds that are useful as hepatoprotectors. Putri Malu plants extract can be usefull to prevent problem such as Ibuprofen-induced hepatic damage., but study that focus on this topic remain scarce in Indonesia. Objective: To prove the extracted content of the leaves of the Putri Malu plant (Mimosa pudica linn) as a hepatoprotector of hepatic damage in mice (Mus musculus) induced by Ibuprofen. Method: This randomized post-test control group design was conducted at the Experimental Animal Laboratory, Faculty of Veterinary Medicine, Universitas Airlangga. A total of 28 mice were treated with four condition then underwent SGOT and SGPT blood laboratory tests. Results: Group P1 (placebo) had SGOT and SGPT levels averaging 23.87 mg/dl and 13.45 mg/dl, group P2 (ibuprofen dose 7 mg/KgBW) had SGOT and SGPT levels of 29.13 mg/dl and 19.10 mg/dl, group 3 (Putri Malu extract 35 mg/KgBW) had SGOT and SGPT of 24.05 mg/dl and 13.56 mg/dl, and group 4 (ibuprofen dose 7 mg/KgBW and Putri Malu extract of 35 mg/KgBW) showed SGOT and SGPT levels of 28.23 mg/dl and 18.35 mg/dl. The four groups had different mean SGOT and SGPT levels (P 0,000). Conclusion:Leaf extract of the Putri Malu plants (Mimosa pudica linn) has a chemical effect of heaptoprotector as shown by the decrease in SGOT and SGPT level.
Efektivitas Biaya Sacubitril / Valsartan dalam Mengurangi Rehospitaliasasi pada Pengobatan Gagal Jantung dengan Fraksi Ejeksi Berkurang Dibandingkan dengan Penggunaan Obat Golongan Ace Inhibitor Kharisma Sukma Nanda; Muhammad Perdana Airlangga; Nurma Yuliyanasari; Yudith Annisa Ayu Rezkitha
JURNAL IMPLEMENTA HUSADA Vol 2, No 1 (2021)
Publisher : UMSU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jih.v2i1.6950

Abstract

Gagal jantung merupakan masalah kesehatan masyarakat  dengan angka morbiditas dan mortalitas yang cukup besar, serta risiko kematian yang tinggi  pada negara maju maupun negara berkembang, sehingga membutuhkan manajemen terapi yang tepat untuk mengurangi morbiditas dan mortalitas. ACEI / ARB adalah standar perawatan yang biasa digunakan selama ini, namun sacubitril / valsartan banyak dibicarakan dan memberikan resiko kematian yang lebih rendah serta mengurangi rehospitalisasi pada pasien gagal jantung dibandingkan dengan penggunaan ACEI. Oleh karena itu, sacubitril / valsartan cenderung lebih hemat biaya dibandingkan dengan ACEI (standar perawatan saat ini). Tujuan penulisan ini untuk mengetahui efektivitas biaya sacubitril / valsartan dibandingkan dengan enalapril (ACEI) dalam pengobatan gagal jantung dengan fraksi ejeksi berkurang.
Co-Authors Ahmad Siddiq Muhajir Ami Ashariati Andre Bagaskara Astri Dewayani Bestya Presidiana Delia Nur Aini Dwiki Noni Armyta I'tishom, Reny Irawati, Detti Nur Iswan A Nusi Kamal Musthofa Kartika Afrida Fauzia Kharisma Sukma Nanda Khodijah Nidaul Chasanah Lionardy Yodianto Lionardy Yodianto Muhammad Anas Muhammad Miftahussurur Muhammad Perdana Airlangga, Muhammad Perdana Naufal Fauzy Nenny Triastuti Nur Firdaos Nurma Yuliyanasari, Nurma Pangestu Adi Prahastutik, Rizkia Hani Rafiqy Sa&#039;adiy Faizun Rafiqy Sa’adiy Faizun Rahmat Sayyid Zharfan Ricky Indra Alfaray Ricky Indra Alfaray Ricky Indra Alfaray Ricky Indra Alfaray Samsriyaningsih Handayani Saruuljavkhlan Batsaikhan Saruuljavkhlan Batsaikhan Umaimah Rosyidah Ummi Maimunah Yoshio Yamaoka, Yoshio Yudhistira Pradnyan Kloping Yudho, S. Ugroseno