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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journal of Islamic Medicine MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Biomolecular and Health Science Journal Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Implementa Husada
Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu
Faculty Of Medicine Universitas Muhammadiyah Surabaya, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan

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Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus) Andre Bagaskara; Nenny Triastuti; Nurma Yuliyanasari; Yudith Annisa Ayu Rezkitha; Muhammad Anas; Ricky Indra Alfaray
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 9, No 1 (2022): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.9.1.2022.01-09

Abstract

Background:Putri Malu plants (Mimosa pudica linn) contain flavonoid compounds that are useful as hepatoprotectors. Putri Malu plants extract can be usefull to prevent problem such as Ibuprofen-induced hepatic damage., but study that focus on this topic remain scarce in Indonesia. Objective: To prove the extracted content of the leaves of the Putri Malu plant (Mimosa pudica linn) as a hepatoprotector of hepatic damage in mice (Mus musculus) induced by Ibuprofen. Method: This randomized post-test control group design was conducted at the Experimental Animal Laboratory, Faculty of Veterinary Medicine, Universitas Airlangga. A total of 28 mice were treated with four condition then underwent SGOT and SGPT blood laboratory tests. Results: Group P1 (placebo) had SGOT and SGPT levels averaging 23.87 mg/dl and 13.45 mg/dl, group P2 (ibuprofen dose 7 mg/KgBW) had SGOT and SGPT levels of 29.13 mg/dl and 19.10 mg/dl, group 3 (Putri Malu extract 35 mg/KgBW) had SGOT and SGPT of 24.05 mg/dl and 13.56 mg/dl, and group 4 (ibuprofen dose 7 mg/KgBW and Putri Malu extract of 35 mg/KgBW) showed SGOT and SGPT levels of 28.23 mg/dl and 18.35 mg/dl. The four groups had different mean SGOT and SGPT levels (P 0,000). Conclusion:Leaf extract of the Putri Malu plants (Mimosa pudica linn) has a chemical effect of heaptoprotector as shown by the decrease in SGOT and SGPT level.
Co-Authors Ahmad Siddiq Muhajir Ami Ashariati Andre Bagaskara Astri Dewayani Bestya Presidiana Delia Nur Aini Dwiki Noni Armyta I'tishom, Reny Irawati, Detti Nur Iswan A Nusi Kamal Musthofa Kartika Afrida Fauzia Kharisma Sukma Nanda Khodijah Nidaul Chasanah Lionardy Yodianto Lionardy Yodianto Muhammad Anas Muhammad Miftahussurur Muhammad Perdana Airlangga, Muhammad Perdana Naufal Fauzy Nenny Triastuti Nur Firdaos Nurma Yuliyanasari, Nurma Pangestu Adi Prahastutik, Rizkia Hani Rafiqy Sa'adiy Faizun Rafiqy Sa’adiy Faizun Rahmat Sayyid Zharfan Ricky Indra Alfaray Ricky Indra Alfaray Ricky Indra Alfaray Ricky Indra Alfaray Samsriyaningsih Handayani Saruuljavkhlan Batsaikhan Saruuljavkhlan Batsaikhan Umaimah Rosyidah Ummi Maimunah Yoshio Yamaoka, Yoshio Yudhistira Pradnyan Kloping Yudho, S. Ugroseno