Rusmana Wijaya Setia Ningrat
Universitas Andalas, Padang

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Pembuatan dan Karaterisasi Tablet NPN Lepas Lambat Berlapis Polikaprolakton Sebagai Suplement Ruminansia Edtyva Monicha; Akmal Djamaan; Rini Agustin; Rusmana Wijaya Setia Ningrat
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3642

Abstract

Productivity of ruminant cattle can be increased by providing non-protein nitrogen, especially urea. Urea not only has benefits as a plant fertilizer, but is also used as a substitute for nitrogen sources for ruminants. The purpose of this research is to use urea more efficiently because urea in the rumen is degraded more quickly to form ammonia so that urea excretion becomes faster in the urine. In this study it was designed so that urea is released in a slow release, its use is more practical and the dosage is correct. The method used is to make urea tablets and then coat them with a coating, characterize the tablets including their shape and urea content, then test the release of the tablets in vitro in rumen fluid. Based on this, the characteristics of the tablets are using Scanning electron microscopy (SEM), Differential Scanning Calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) methods. From the results of the study showed that urea tablets fulfilled the tablet evaluation including tests for uniformity in size, weight variation, tablet hardness and friability. Meanwhile, for testing the release of urea tablets in the rumen fluid, it can be seen from testing that 70% of the urea tablets without coating were released, while for the coated urea tablets, only 15% were released in the first minute. Sequentially the release of urea tablets from the first minute with three successive repetitions of the test was 14.641; 15.323 and 14.798 %. Meanwhile, tablets that were not coated in the first minute released as much as 71.257%. For this reason, the manufacture of polycaprolactone-coated slow release urea tablets makes urea more beneficial for ruminants without rapid excretion and lasts longer in the rumen so that rumen microbes take advantage of this nitrogen source to form microbial protein.
Formulasi dan Evaluasi Tablet Urea Lepas Lambat Berlapis Biopolimer Poliasam Laktat Sebagai Suplemen Ruminansia Bilqis Nurganiyu; Akmal Djamaan; Rini Agustin; Rusmana Wijaya Setia Ningrat
Journal of Pharmaceutical and Health Research Vol 4 No 2 (2023): June 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i2.3651

Abstract

Urea is a source of non-protein nitrogen (NPN) which can be used to replace pure protein in ruminants. Urea is easily soluble and is degraded to ammonia by rumen bacteria, thus affecting the quality of ruminants. To increase the utilization of urea as a supplement is to try to slow its release into ammonia in the rumen so that it can be used efficiently by rumen microbes to form microbial protein. Slow release urea tablets as an alternative can control the rate of urea degradation and release of ammonia into the rumen and increase rumen efficiency. This study aims to determine the rate and pattern of release of urea tablets in the rumen so that their use is more practical and the dosage is correct. To maintain ammonia levels in the rumen, an alternative polymer-coated urea slow release tablet was designed. Based on this, it was carried out to manufacture slow release urea tablets with biopolymer polylactic acid (PLA) coating in the rumen fluid of ruminants. Furthermore, an in vitro evaluation was carried out by measuring pH into rumen fluid and measuring NH3 by UV-Vis spectro analysis at a wavelength of 630 nm. The results of the test for urea release in the rumen in formulas 1, 2 and 3 were 75.133%, 76.076% and 74.051% respectively, while the release of urea in uncoated urea tablets was 96.384%, these results indicate that tablets with lactic acid coated polyacid last longer. release compared to urea tablets without biopolymer coating.