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Puspita Sari Dyah Ratna Ayu
Program Studi Diploma Farmasi, Institut Teknologi dan Kesehatan Bintang Persada
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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VOLUME PENOTOLAN MEMPENGARUHI FINGERPRINT EKSTRAK METANOL HERBA SAMBILOTO (ANDROGRAPHIS PANICULATA (BURM. F.) NEES) DENGAN KLT-SPEKTROFOTODENSITOMETRI Ugrasena Putu Yudha; Puspita Sari Dyah Ratna Ayu; Kumara Dewi Ni Wayan Rika
Journal Pharmactive Vol. 2 No. 1 (2023): Jurnal Pharmactive April
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Abstract

Spotting volume is an important factor affecting the resolution value of the chromatogram, the number of peaks and separation, peak profile and peak broadening, as well as the asymmetry of the peaks. This study aims to determine the effect of bottling volume on fingerprint chromatography of the methanol extract of Andrographis paniculata (Burm. F.) Nees herb and to determine fingerprint chromatography at optimum volume. The chromatographic system used refers to the Indonesian Herbal Pharmacopoeia. Sambiloto herbal samples were spotted with a variety of 3 µL bottling volumes; 5µL; 10µL; 15µL; 20 µL and 25 µL on a 60 GF254 silica gel plate were then eluted with a mixture of chloroform P and methanol P (9:1) v/v. The plates were scanned with a TLC Scanner 3 (CAMAG) at a wavelength of 210 nm. Spectra were made for each spot at a wavelength of 190-400 nm. Parameters that were calculated were resolution values, tailing factor from andrographolid peaks, and cosine functions (C) from volume variation chromatograms to determine the effect of spotting volume. The bottling volume selected from the optimization step was 5 µL with andrographolid peak resolution with the previous and following peaks being 1.57 and 1.16, respectively. The tailing factor value was 1 and the number of peaks that appeared was 10. The average value of C in the 5 µL bottling volume precision test was 99.36 with a VC of 1.17% (VC <2%)
ANTIBACTERIAL POTENTIAL OF RED BETEL LEAVES (Piper crocatum Ruiz and Pav) Kumara Dewi Ni Wayan Rika; Ugrasena Putu Yudha; Puspita Sari Dyah Ratna Ayu
Journal Pharmactive Vol. 2 No. 1 (2023): Jurnal Pharmactive April
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

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Background: Red betel leaf (Piper crocatum Ruiz and Pav.) is one of the medicinal plants which empirically has the efficacy of healing spiritual ailments. The secondary metabolite compounds contained in red betel leaves are essential oils, flavonoids, alkaloids, saponins, tannins, terpenoids, and phenolic compounds which have antibacterial activity. Objective: To determine the antibacterial potential of red betel leaves (Piper crocatum Ruiz and Pav.) Method: This study uses a descriptive method using a structured article review method. Data collection was carried out using the Google Scholar database, Science Direct and PubMed with keywords “Piper crocatum Ruiz and Pav”, “Piper crocatum”, “Screening phytochemical”, Piper crocatum”, “Leaf Piper crocatum”, and “antibacterial Piper crocatum”. Results: Based on literature studies, the antibacterial potential of red betel leaves (Piper crocatum Ruiz and Pav.) can be seen from the inhibition zones produced for both gram-positive and gram-negative bacteria, although with different values of the resulting inhibition zones.
Co-Authors Ariyanti Ni Nyoman Ni Luh Gde Mona Monika Ni Wayan Rika Kumara Dewi Putu Yudha Ugrasena