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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Meditory : The Journal of Medical Laboratory JFM (Jurnal Farmasi Malahayati) JURNAL ILMIAH KESEHATAN SANDI HUSADA Muhammadiyah Medical Journal Jurnal Pengabdian kepada Masyarakat Wahana Usada Jurnal Yoga Dan Kesehatan Journal Pharmactive
Ni Wayan Rika Kumara Dewi
Institut Teknologi Dan Kesehatan Bintang Persada
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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ISOLASI DAN IDENTIFIKASI SENYAWA ANTIOKSIDAN GOLONGAN FLAVONOID DARI EKSTRAK ETIL ASETAT DAUN PRANAJIWA (Euchresta horsfieldii Lesch Benn.) Ni Wayan Rika Kumara Dewi; I Wayan Gunawan; Ni Made Puspawati
CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Vol 5 No 1 (2017)
Publisher : Magister Program of Applied Chemistry, Udayana University, Bali-INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.127 KB) | DOI: 10.24843/CK.2017.v05.i01.p04

Abstract

ABSTRAK: Penelitian ini bertujuan untuk menentukan aktivitas antioksidan dan mengidentifikasi senyawa golongan flavonoid yang terkandung dalam ekstrak etil asetat daun pranajiwa (Euchresta horsfieldii Lesch Benn.). Uji aktivitas antioksidan dilakukan secara invitro dengan metode DPPH (1,1-diphenyl-2-pycrylhidrazyl). Teknik pemisahan dilakukan dengan kromatografi kolom dan diidentifikasi dengan spektrofotometer FTIR dan UV-Vis. Hasil penelitian menunjukkan bahwa ekstrak etil asetat memiliki aktivitas antioksidan dengan nilai IC50 sebesar 393,95 µg/mL dan kadar total flavonoid sebesar 6619,72 mg QE/100g atau 6,62 % QE. Pemisahan dan pemurnian ekstrak etil asetat menggunakan fase diam silika gel 60 dan fase gerak n-heksana:kloroform: etanol (20:1:1) yang menghasilkan isolat aktif yang positif flavonoid (isolat FE) yang diduga merupakan senyawa flavonoid golongan flavonol yaitu 3,5,7,3’,4’-pentahidroksi flavonol. ABSTRACT: The present study was conducted to determine antioxidant activity and to identify the flavonoid active compounds from ethyl acetate extracts of Pranajiwa leaves. In vitro antioxidant activity was carried out using DPPH (1,1-diphenyl-2-pycrylhidrazyl) method. The separation of the ethyl acetate extracts was conducted by column chromatography and the identification by using FTIR and UV-Vis spectrophotometer. The results showed that ethyl acetate extract has antioxidant activity with IC50 value of 393,95 µg/mL and the total flavonoid of 6619,72 mg QE /100g or 6,62% QE. The separation and purification of ethyl acetate extract was chromatography column on silica gel 60 and the solvent n-hexane:chloroform:ethanol (20:1:1) based on UV-Vis and Infrared spectra positive flavonoid isolate (isolates FE) was tentaviely identified as 3,5,7,3',4'-pentadihydroxy flavonols.
Primers application with the Tso31 gene target in the molecular identification of Taenia solium Nur Habibah; Heri Setiyo Bekti; Ni Wayan Rika Kumara Dewi; Luh Putu Rinawati; Burhannuddin Burhannuddin; Aprilia Rakhmawati
Muhammadiyah Medical Journal Vol 2, No 1 (2021): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.651 KB) | DOI: 10.24853/mmj.2.1.35-40

Abstract

Background: taeniasis is a zoonotic disease caused by Taenia spp. Human taeniasis caused by Taenia solium can be acquired after consumption of raw insufficiently cooked infected pork meat. Pigs are intermediate host for T.solium. Pigs acquired this infection by eating human feces that contained T.solium eggs. Pigs infected with T.solium can be transmitted to humans. Purposes: identification of T.solium in pig is important because it is indicator of T.solium transmission. Microscopic examination of T.solium eggs is considered less effective and efficient so that many other methods are developed for T.solium detection such as molecular and immunology. Method: This method used specific primer which can detect the Tso31 gene in T.solium. Tso31 gene is one of the most promising antigens to differentiate T.solium from T.saginata. Pig feces samples were taken by random sampling technique from 7 pig farms in Denpasar. Result: from the 30 samples, we found one sample that which gave a single amplification product of 234 bp. This indicates that the pig farms in Denpasar have been infected with T.solium. Conclusion: it is necessary to do meat inspection properly in the market as well as health education about the dangers and impacts of T.solium infection in the community.
The Effectiveness of Green Grape Extract (Vitis vinifera) on Decreasing White Rat (Rattus novergicus) Triglycerides Levels Ketut Lilik Arwati; Ni Nyoman Astika Dewi; Heri Setiyo Bekti; Ni Wayan Rika Kumara Dewi; Andi Udin Saransi
Muhammadiyah Medical Journal Vol 3, No 1 (2022): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.3.1.1-9

Abstract

Background: Grapes (Vitis vinifera) are a source of antioxidants with high content of polyphenols and anthocyanins. Grape skin is rich in flavonoids. Anthocyanins and flavonoids have the effect of lowering blood triglyceride levels. Purposes: This study aimed to determine the effect of using green grape extract (GGE) in lowering triglyceride levels in the blood. Methods: Five groups of white male rats (Rattus novergicus) were divided into a negative control group (KN), positive control (KP), rats with a GGE dose of 100 mg/200g BW as P1, rats with a GGE dose of 250mg/200g BW as P2, and rats with GGE dose of 500 mg/200g BW as P3. Each group was given a hypercholesterolemic diet for five weeks. Groups P1, P2, and P3 were given GGE according to their respective doses for 14 days, then measured triglyceride levels in the blood. Results: The results showed that GGE 500mg/200g BW significantly reduced triglyceride levels in all treated mice. Conclusion: These results indicate that GGE has a great potential to treat dyslipidemia by lowering triglyceride levels in the blood.
ISOLASI DAN IDENTIFIKASI SENYAWA AKTIF ANTIRADIKAL BEBAS DARI KULIT BATANG KEPUH (Sterculia foetida L.) Ni Wayan Rika Kumara Dewi; Made Dwike Swari Shanti
Jurnal Farmasi Malahayati Vol 5, No 1 (2022)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v5i1.6799

Abstract

Penelitian ini bertujuan untuk menentukan senyawa aktif antiradikal bebas dari kulit batang kepuh (Sterculia foetida L.). Uji aktivitas dilakukan secara invitro dengan metode DPPH (1,1-diphenyl-2-pycrylhidrazyl). Teknik pemisahan dilakukan dengan kromatografi kolom dan diidentifikasi dengan spektrofotometer FTIR dan UV-Vis.Hasil maserasi yang memiliki aktivitas adalah ekstrak etanol. Selanjutnya dipartisi dengan etil asetat dan kloroform, diperoleh ekstrak kloroform yang menunjukkan hasil uji aktivitas antiradikal bebas yang paling tinggi dan dilanjutkan teknik pemisahan. Ekstrak dipisahkan dengan kromatografi kolom dengan fase diam silika gel. Pemisahan dan pemurnian menghasilkan 9 fraksi gabungan (A, B, C, D, E, F, G, H, I). Berdasarkan uji antiradikal bebas, semua fraksi menunjukkan hasil positif antiradikal bebas, yang relatif murni secara KLT adalah fraksi B yang berbentuk serbuk berwarna kuning muda seberat 0,0325 gram. Identifikasi dengan pereaksi Leibermann Burchard menunjukkan isolat FB adalah golongan senyawa triterpenoid. Spektrum UV-Vis dari isolat FB dengan dua puncak utama yang muncul pada panjang gelombang 212 nm sebagai λ maks diduga jenis transisi yang terjadi pada panjang gelombang 212 nm kemungkinan diakibatkan oleh terjadinya transisi elektronik dari n-σ* dari kromofor C=O dan puncak yang lain berupa bahu pada panjang gelombang 284 nm diakibatkan oleh terjadinya transisi elektronik n-π* dari ikatan rangkap C=O. Dugaan ini diperkuat oleh data dari spektrum inframerah yang menunjukkan adanya gugus fungsi –OH, CH alifatik, C=O, C=C alifatik, dan C-O.
Gambaran Kadar Hemoglobin Dan Protein Urin Pada Ibu Hamil Luh Putu Rinawati; Ni Putu Ditya Prabandari Dewi; Ni Putu Yulia Rahma Dewi; Ni Komang Omik Trianita Udiana; Ni Wayan Rika Kumara Dewi; Heri Setiyo Bekti
Meditory : The Journal of Medical Laboratory Vol 10, No 2 (2022): meditory, Volume 10 No 2
Publisher : Jurusan Analisis Kesehatan, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v10i2.2279

Abstract

Backgrounds of hemoglobin is a metalloprotein in red blood cells that functions as an oxygen booster from the lungs to the rest of the body. To maintain hemoglobin levels in the body, especially in pregnant women, it is necessary to have adequate intake of nutrients, namely iron. If the intake of iron in pregnant women is less, it will increase the risk of anemia. Anemia is a condition or condition that causes low levels of hemoglobin (Hb). Albuminuria or proteinuria is a condition in which urine or urine contains an abnormal amount of albumin. Throughout pregnancy, pregnant women are usually advised to take a urine test. One of the focuses of the urine test is to determine urine protein levels in pregnant women. In pregnant women, there is a phase where urine protein levels increase, namely, lack of fluids, exposure to cold and extreme weather, new strenuous activities, and emotional stress also often causes urine protein levels in pregnant women to increase, and impaired kidney function. or urinary tract infection. The method we used in this research is descriptive research method to describe the levels of hemoglobin (Hb) and urine protein in pregnant women at the Ubud 1 Public Health Center, Gianyar-Bali. With the sampling technique using the probability sampling method, with a simple random sampling technique. The results of 41 respondents, that pregnant women who have normal Hb levels (≥ 11 g/dL) at Puskesmas Ubud 1 were found to be more than pregnant women who have low Hb levels ( 11 g/dL). And from the total sample, as well as 2 pregnant women from the urine protein level examination data were positive. The conclusion after averaging the Hb and urine protein levels of pregnant women at the ubud 1 health center that it can be said that the health condition of pregnant women is quite good, but there are still some respondents who show results that are not in accordance with normal limits, therefore it is important to maintain health and pattern healthy living.Keywords: hemoglobin, urine protein, pregnant women
Peningkatan Pemahaman Siswa Farmasi tentang Peran Farmakoekonomi dalam Pelayanan Kesehatan di SMK Bintang Persada Denpasar Made Dwike Swari Santi; Ni Wayan Rika Kumara Dewi; Gede Terima Yasa
Jurnal Pengabdian kepada Masyarakat Wahana Usada Vol. 4 No. 2 (2022): Desember : Jurnal Pengabdian kepada Masyarakat Wahana Usada
Publisher : Sekolah Tinggi Ilmu Kesehatan KESDAM IX/Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47859/wuj.v4i2.284

Abstract

Background: Pharmacoecomics has been defined as the description and analysis of the costs of drug therapy to health care systems and society. Pharmacoeconomics research identifies, measure, and compares the costs and consequences of pharmaceutical product and service. Within this framework, research and methods related to cost-minimization, cost-effectiveness, quality-of-life and other humanistic assessments are include. In-essence, pharmacoeconomics analysis uses tools for examining the impact of alternative drug therapies and other medical interventions Based on this background, the author is interested to explain about the role of Pharmacoecomics on health service in pharmacist students at Bintang Persada School, Denpasar. Purpose: The purpose of this activity is as a form of implementation of Tri Dharma Stikes Bali Wisnu Dharma Denpasar. Methods: Participants who took part in this activity were 83 students using the pretest and posttest methods. Results: The results obtained were an increase in the pretest score (before being given education) which was 62.11% to 83.22% in the posttest result (after being given education). Conclusion: There is a significant relationship between posttest scores, which increases after education is held, so pharmacoeconomics education needs to be given and pharmaceutical products utilization in health service followed by cost utillity evaluation and cost effectiveness as well as impact evaluation of quality adjusted life years of patients.
PEMANFAATAN DAN POTENSI ANTIOKSIDAN PADA BUNGA TELANG (Clitorea ternatea L.) : Literatur Review Ni Wayan Rika Kumara Dewi
Journal Pharmactive Vol. 1 No. 2 (2022): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.688 KB)

Abstract

Abstrak Latar belakang : Bunga telang memiliki potensi antioksidan karena memiliki kandungan antosianin dan flavonoid lainnya. Antosianin diketahui mampu memberikan aktivitas antioksidan. Selain itu bunga telang juga sering dimanfaatkan dalam bidang pangan. Hal ini menunjukkan potensi besar pemanfaatan bunga telang oleh masyarakat luas, sehingga perlu dikaji terkait pemanfaatan dan potensi antioksidan bunga telang (Clitoria ternatea L.) Tujuan: Untuk mengetahui manfaat dan potensi antioksidan dari bunga telang (Clitoria ternatea L.) dengan berbagai metode yaitu DPPH, FRAP, ABTS, BTA, CUPRAC. Metode: Penelitian ini menggunakan metoda deskriptif dengan menggunakan metode review artikel terstruktur. Pengumpulan data dilakukan menggunakan basis data Google Scholar, Science Direct danPubMed dengan kata kunci “Clitoria ternatea L. antioxidant activity”, “Clitoria ternatea L.”, “phytochemical analysis of Clitoria ternatea L.”, “traditional use of Clitoria ternatea L.”Hasil: Berdasarkan studi literatur pemanfaatan bunga telang digunakan dalam bidang pangan dan kesehatan yaitu mencegah glikasi protein dan kerusakan DNA oksidatif, Mengerahkan efek protektif terhadap Bisphenol A (BPA) terhadap kinerja reproduksi dalam meningkatkan persentase kehamilan dan ukuran anak, memodulasi efek perlindungan terhadap paparan UVR pada kulit, dan meningkatan stabilitas dalam pangan fungsional dalam bentuk bubuk minuman fungsional dan sebagai pewarna makanan Kesimpulan: Bunga telang (Clitoria ternatea L.) memiliki aktivitas biologis sebagai antioksidan dan memiliki manfaat di bidang pangan dan kesehatan. Pada potensi antioksidan yang diperoleh dari beberapa literatur dengan metode yang berbeda memberikan perbedaan nilai IC50.
The Kajian Manfaat Tumbuhan Kepuh (Sterculia Foetida L.) Dan Terapi Yoga Sebagai Pengobatan Tradisional Ni Wayan Rika Kumara Dewi; Iwan Saka Nugraha; Made Prita Artika
Jurnal Yoga dan Kesehatan Vol 6 No 1 (2023): Volume 6 Nomor 1 Maret 2023
Publisher : UHN IGB Sugriwa Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25078/jyk.v6i1.2007

Abstract

Kepuh plant (Sterculia foetida L.) is one of the plants that have the potential as a source of new medicines which are rich in compounds used as modern medicines, pharmaceutical intermediates, and main compounds in natural medicinal ingredients. Traditional medicine in Bali is often called Usada which contains the science of diagnosing diseases, medicinal ingredients, and prayers. The community is also familiar with Ayurveda, namely the use of herbal medicines and yoga therapy. The development of traditional medicine into herbal medicine requires an analysis of the activity of primary metabolites present in the Kepuh plant (Sterculia foetida L.). In addition, it is also necessary to know the effect of yoga therapy on traditional medicine. This study uses a descriptive method using a structured article review method. Based on secondary data obtained from several scientific journals, it is known that the biological activities of secondary metabolites in the Kepuh plant (Sterculia foetida L.) are antibacterial, antioxidant, antifungal, antiprotozoal, cytotoxic, thrombolytic, anti-rheumatic, analgesic, antipyretic, antidiabetic, insecticidal, antifeedant, and microbicidal effects. So scientifically the Kepuh plant (Sterculia foetida L.) can be used as a source of new drugs which are rich in compounds used as modern medicines, pharmaceutical intermediates, and main compounds in natural medicinal ingredients. Likewise, the effect of giving yoga therapy to traditional medicine which is a non-pharmacological treatment can help the healing process in patients with certain diseases. However, it is necessary to carry out further research on the use of the Kepuh plant as a herbal medicine in combination with yoga therapy.
Andrografolid : Potensi Sebagai Antiaterosklerosis Pada Sitokin Il-1β Putu Yudha Ugrasena; Iwan Saka Nugraha; Ni Wayan Rika Kumara Dewi
Jurnal Ilmiah Kesehatan Sandi Husada Vol 12 No 1 (2023): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v12i1.991

Abstract

The focus is how the role of cytokines in atherosclerosis as a chronic inflammatory disease, as it is known that cytokines regulate complex inflammatory responses in atherosclerotic plaques, especially IL-1β. Sambiloto (Andrographis paniculata) is a plant with various pharmacological activities. Andrographolide (AND) is the main bioactive compound in the diterpene lactone group. This literature study aims to assess the potential of AND on the proinflammatory cytokine IL-1 β as an antiatherosclerosis. This type of research is a qualitative review of various studies using sambiloto plants or andrographolide compounds (AND). Search literature using the Google Scholar database. Keywords used "Andrographis paniculata, andrographolide, IL-1β, Atherosclerosis. The results showed that AND has effects as an anti-inflammatory, antiatherosclerosis as well as cardiovascular-related diseases. There are not many articles on the activity of AND in IL-1β against atherosclerosis, but AND can provide inhibitory activity of the cytokine IL-1β against inflammation. Not many researchers have discussed the pharmacological effects of AND as an antiatherosclerotic on IL-1β therapeutic targets, but from the results of the review AND has a strong potential in inhibiting IL-1 cytokine secretion β.
VOLUME PENOTOLAN MEMPENGARUHI FINGERPRINT EKSTRAK METANOL HERBA SAMBILOTO (ANDROGRAPHIS PANICULATA (BURM. F.) NEES) DENGAN KLT-SPEKTROFOTODENSITOMETRI Ugrasena Putu Yudha; Puspita Sari Dyah Ratna Ayu; Kumara Dewi Ni Wayan Rika
Journal Pharmactive Vol. 2 No. 1 (2023): Jurnal Pharmactive April
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Spotting volume is an important factor affecting the resolution value of the chromatogram, the number of peaks and separation, peak profile and peak broadening, as well as the asymmetry of the peaks. This study aims to determine the effect of bottling volume on fingerprint chromatography of the methanol extract of Andrographis paniculata (Burm. F.) Nees herb and to determine fingerprint chromatography at optimum volume. The chromatographic system used refers to the Indonesian Herbal Pharmacopoeia. Sambiloto herbal samples were spotted with a variety of 3 µL bottling volumes; 5µL; 10µL; 15µL; 20 µL and 25 µL on a 60 GF254 silica gel plate were then eluted with a mixture of chloroform P and methanol P (9:1) v/v. The plates were scanned with a TLC Scanner 3 (CAMAG) at a wavelength of 210 nm. Spectra were made for each spot at a wavelength of 190-400 nm. Parameters that were calculated were resolution values, tailing factor from andrographolid peaks, and cosine functions (C) from volume variation chromatograms to determine the effect of spotting volume. The bottling volume selected from the optimization step was 5 µL with andrographolid peak resolution with the previous and following peaks being 1.57 and 1.16, respectively. The tailing factor value was 1 and the number of peaks that appeared was 10. The average value of C in the 5 µL bottling volume precision test was 99.36 with a VC of 1.17% (VC <2%)
Co-Authors Andi Udin Saransi Aprilia Rakhmawati Burhannuddin Gede Terima Yasa Heri Setiyo Bekti I Wayan Gede Gunawan Iwan Saka Nugraha Ketut Lilik Arwati Made Dwike Swari Santi Made Prita Artika Ni Komang Omik Trianita Udiana Ni Luh Gde Mona Monika Ni Made Puspawati Ni Nyoman Astika Dewi Ni Putu Ditya Prabandari Dewi Ni Putu Gita Puspita Sari Ni Putu Yulia Rahma Dewi Nur Habibah Puspita Sari Dyah Ratna Ayu Putu Yudha Ugrasena Rinawati, Luh Putu