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All Journal JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Farmako Bahari Indonesian Journal of Pharmaceutical and Clinical Research Lumbung Farmasi : Jurnal Ilmu Kefarmasian Journal of Pharmaceutical Care Anwar Medika Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Praktis Journal of Pharmacy Science and Technology
Ana Khusnul Faizah
Universitas Hang Tuah
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Indonesian Journal of Pharmaceutical and Clinical Research

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Evaluation of Antiinflammatory Activity of Marine Omega-3 in Rats Faizah, Ana Khusnul; Kresnamurti, Angelica
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (806.788 KB) | DOI: 10.32734/idjpcr.v2i2.2666

Abstract

Marine omega-3 from fish contains high EPA dan DHA which may have an analgesic and anti-inflammatory effects. The objective of study is to analyze the anti-inflammatory effect of marine omega-3 in rats. The method of this study is pre-post control experimental. The acute anti-inflammatory effect of marine omega-3 were investigated through carrageenan induced paw edema in rats. Thirty minutes before the procedure, the experimental groups were treated with fish oil 40 and 60 mg/kg; sodium diclofenac (5 mg/kg) as positive control groups and span 80-tween 80 as negative control groups. The degree of paw edema was measured by caliper. The marine omega-3 showed anti-inflammatory effect in a dose-dependent manner. The results of 60 mg/kg of marine omega-3 was significantly different compared with the negative. Overall, the marine omega-3 has acute anti-inflammatory activity in rats.
Co-Authors Adinda Kumala Sari Amitasari Damayanti Andayani, Rina Angelica Kresnamurti Angelica Kresnamurti Angelica Kresnamurti Effendi Rachmat Eri Destin Anggraini Ersanda Praditapuspa Giftani Wardani Sudjwaro Hardiyono _ Jala Kesit Dewayani Kresnamurti, Angelica Lestiono Lestiono Nani Khusnul Wijayanti DN Nani W.D Nurrahman Oki Nugraha Putra Oki Nugraha Putra Oki Nugraha Putra Risca Amilia Widyananda Kartikasari Yagi Dimas Nuryanto