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Journal : Jurnal Ilmiah Kedokteran Wijaya Kusuma

The Role of Cytokines in Inflammatory Process of Knee Osteoarthritis: Systematic Review Florencia Christofora Ngantung; Basuki Supartono; Hikmah Muktamiroh
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 2 (2022): SEPTEMBER 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (295.059 KB) | DOI: 10.30742/jikw.v11i2.2444

Abstract

Osteoarthritis (OA) is a degenerative joint disorder that occurs in cartilage. OA is the main cause of disability in adults and generally characterized by pain to the joints that got pressured. Based on several previous studies, it is known that the incidence of osteoarthritis is correlated with synovial inflammation and that inflammatory cytokines play an important role in the expansion of osteoarthritis. Based on these things, the author intends to conduct a literature study with the aim of knowing the role of cytokines on inflammation in knee osteoarthritis. The research was conducted through PubMed and Science Direct databases. The results of the study showed that cytokines played negative different roles depending on the type of cytokines such as those found in knee OA inflammation. Conclusion: Cytokines have a negative effect because they can disrupt synovial tissue balance, induce catabolic processes, and induce osteoclast differentiation and subchondral bone resorption.
HUBUNGAN ANTARA KELEBIHAN BERAT BADAN DENGAN KEKUATAN TULANG PEREMPUAN LANSIA Denina Kusumaningayu Puspitarini; Basuki Supartono; Yuli Suciati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 2 (2021): SEPTEMBER 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.216 KB) | DOI: 10.30742/jikw.v10i2.1197

Abstract

Osteoporosis merupakan salah satu penyakit degeneratif yang banyak terjadi pada perempuan lansia. Terdapat beberapa faktor risiko diantaranya adalah usia dan indeks massa tubuh. Berat badan berlebih pada lansia dapat mempengaruhi kekuatan tulang yang mungkin memberikan efek protektif, sehingga penelitian ini bertujuan untuk mengetahui hubungan antara kelebihan berat badan (overweight dan obesitas) dengan kekuatan tulang perempuan lansia. Penelitian ini merupakan observasional analitik dengan desain potong lintang dan pendekatan korelasi. Dengan teknik acak sederhana, sejumlah 104 perempuan lansia dihitung indeks massa tubuh menggunakan timbangan dan staturameter serta diukur kekuatan tulangnya menggunakan BMD (Bone Mineral Densitometry) jinjing sebagai deteksi dini osteoporosis, yang dilakukan di Rumah Sakit Umum Al-Fauzan, Kota Jakarta Timur, pada bulan Oktober 2019. Hasil penelitian didapatkan subjek overweight sebanyak 77 orang (74%) dan obesitas 27 orang (26%). Dari subjek overweight terdapat 68 orang (88,3%) menderita osteoporosis, dan 9 orang (11,7%) menderita osteopenia. Dari subjek obesitas 22 orang (81,5%) menderita osteoporosis dan 5 orang (18,5%) menderita osteopenia. Berdasarkan uji Chi-Square dari kedua varibel, dapat disimpulkan bahwa penelitian ini tidak menunjukkan hubungan yang bermakna antara kelebihan berat badan dengan kekuatan tulang perempuan lansia, p= 0.512 (derajat kemaknaan < 0.05). Kelebihan berat badan seperti overweight ataupun obesitas mungkin tidak dianggap sebagai faktor pelindung terhadap osteoporosis pada perempuan lanjut usia.
Hormone Therapy as A New Hope for Achondroplasia Patients Basuki Supartono; Ayola Dewi Utami; Abyanka Rayhan Fuadi; Bintang Bayu Aryandi
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (375.971 KB) | DOI: 10.30742/jikw.v11i1.1601

Abstract

Achondroplasia is a disorder of child bone growth due to gene mutation of growth factor receptor. Short stature is a major problem. Efforts to increase height are still a challenge. The method performed so far is the lengthening of the limbs with various complications and risks of re-surgery. A promising new alternative without surgery is the administration of growth hormone therapy. This review aims to find out the safety and effectiveness of hormone therapy. The review method used is a narrative review. The review results showed that growth hormone therapy is safe and effective. The review concludes that growth hormone therapy has been proven to be safe and effective in increasing the height of achondroplasia patients.