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All Journal Indonesian Journal of Pharmaceutical Science and Technology JURNAL FARMASI GALENIKA
Juanda, Dadang
Indonesian Journal of Pharmaceutical Science and Technology
Computer Science & IT Health Professions Medicine & Pharmacology

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Gastric Ulcer Healing Effect of Bangle (Zingiber cassumunar (Roxb.)) Rhizome Extract in Aspirin-induced Rats Model Yuniarto, Ari; Susilawati, Elis; Rahman, Toni Abdul; Setiawan, Finna; Juanda, Dadang
Indonesian Journal of Pharmaceutical Science and Technology Supp 1, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (481.322 KB) | DOI: 10.15416/ijpst.v1i1.10436

Abstract

In the gastrointestinal system, gastric ulcers are one of the common serious diseases. The pathophysiology of gastric ulcer is an imbalance between aggressive and mucosal defense factor. Imbalance between aggressive and mucosal defense factor have contribution against developed of gastric ulcer disease. The objective of the research was to evaluate gastric ulcer healing effect of Bangle (Zingiber cassumunar (Roxb.) rhizome extract in aspirin-induced rats model. Antiulcer activity of Bangle rhizome extract was evaluated by several parameters involving gastric acidity, number of ulcers, diameters of ulcers, ulcer index, and healing ratio. Doses level of Bangle rhizome extract which used in this study such as 50 mg/kg and 100 mg/kg, respectively. Histopathological of the stomach was performed using hematoxylin-eosin stained. The results of study showed that groups which given Bangle rhizome extract have signi cant effect in gastric acidity, number of ulcers, diameters of ulcers, ulcer index, and healing ratio compared to the control group. Histopathological study of the stomach ulcers showed tissues regeneration in group were treated by Bangle rhizome extract compared to the control group. It can be concluded that from the experimental study of Bangle (Zingiber cassumunar (Roxb.)) rhizome extract have potential antiulcer activity in aspirin-induced rats model. Keywords : Zingiber cassumunar (Roxb.), Extract, Ulcer, Aspirin. 
Penetapan Kadar Total Fenol dan Aktivitas Antioksidan dari Jus Buah Lima Spesies Jeruk (Citrus sp.) Juanda, Dadang
JURNAL FARMASI GALENIKA Vol 2 No 01 (2015): JURNAL FARMASI GALENIKA
Publisher : Sekolah Tinggi Farmasi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.112 KB)

Abstract

Jeruk merupakan buah yang sering dikonsumsi oleh masyarakat Indonesia, jenis jeruk cukup banyak diantaranya jeruk sunkist (Citrus sinensis Osbeck), jeruk purut (Citrus hystrix D. C.), jeruk nipis (Citrus aurantifolia), jeruk bali (Citrus maxima Merr) dan jeruk garut (Citrus nobilis Lour), kandungan senyawa aktif yang diketahui cukup banyak diantaranya senyawa fenolat yang diketahui memiliki aktivitas sebagai antioksidan. Penelitian ini dilakukan untuk menetapkan kadar senyawa fenol dan aktivitas antioksidan dari dari beberapa spesies jeruk. Buah jeruk diblender  dan filtrat yang diperoleh  di freeze dry sehingga didapat jus kering. Jus jeruk ditentukan kadar total fenol dengan menggunakan reagen Folin Ciocalteau dan aktivitas antioksidan diuji secara in vitro menggunakan metode peredaman radikal bebas DPPH (1,1-difenil-2-pikrilhidrazil). Kadar fenol total  dari jeruk sunkist, jeruk purut, jeruk nipis, jeruk bali dan jeruk garut secara berurutan  98,6 ; 141,7; 81,7; 71,3; 67,4 (mg asam galat/100 g jus). Aktivitas antioksidan dari jeruk sunkist, jeruk purut, jeruk nipis, jeruk bali dan jeruk garut  memberikan EC50 (Efisien Konsentrasi) secara berurutan 732,00; 1.255,07; 1.631,80;  1.739,72; 2.192,2 µg/mL..  
Co-Authors Rahman, Toni Abdul Setiawan, Finna Susilawati, Elis Yuniarto, Ari