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All Journal Indonesian Journal of Pharmaceutical and Clinical Research Jurnal ABDIMAS MUTIARA
Syukur Berkat Waruwu
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Journal : Indonesian Journal of Pharmaceutical and Clinical Research

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Antioxidant activity of 1.3-bis(p-hydroxyphenyl)urea by CUPRAC and FRAP methods Satria, Denny; Rifda Amaliya Ma’ruf; Syukur Berkat Waruwu; Urip Harahap; Hari Purnomo4
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.17768

Abstract

An imbalance in the number of free radicals produced in the body can result in oxidative stress. Excessive oxidative stress can lead to chronic inflammation, which in turn can lead to most chronic diseases. Inflammation is related to oxidation through increased reactive oxidative stress, which can target modulators associated with inflammation, such as inflammatory cytokines. Antioxidants can inhibit or stop oxidation by protecting the body and neutralizing free radicals. 1.3-bis(p-hydroxyphenyl)urea is a modification of p-aminophenol and has hepatotoxic side effects such as those caused by acetaminophen. This compound can relieve pain, is anti-inflammatory, and has fewer side effects. This research was conducted to evaluate the antioxidant activity of 1.3-bis(p-hydroxyphenyl)urea using the CUPRAC (Cupric Ion Reducing Antioxidant Capacity) method and the FRAP (Ferric Reducing Antioxidant Power) method. The results of the CUPRAC method research show that the 1.3-bis(p-hydroxyphenyl)urea compound has an IC50 value of 4.40 ± 0.07 μg/mL. Meanwhile, the FRAP method was 29.36 ± 1.20 μg/mL. Apart from suppressing inflammation, this compound has the potential to be an antioxidant compound.
Co-Authors Alfi Sapitri Artha Yuliana Sianipar Christica Ilsanna Surbakti Denny Satria, Denny Dian Arisetya Eva Diansari Marbun Ginting, Grace Anastasia br Hari Purnomo4 Marbun, Eva Diansari Modesta Tarigan Realita Lifiani Retnita Ernayani Lubis Reza Fikrih Utama Rifda Amaliya Ma’ruf Sapitri*, Alfi SURBAKTI, CHRISTICA ILSANNA Urip Harahap