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Polifarmasi dan Interaksi Obat Pasien Usia Lanjut Rawat Jalan dengan Penyakit Metabolik Dasopang, Eva S.; Harahap, Urip; Lindarto, Dharma
Indonesian Journal of Clinical Pharmacy Vol 4, No 4 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Penyakit metabolik merupakan penyakit yang berkaitan dengan peningkatan usia seperti hipertensi, diabetes melitus, dislipidemia, dan obesitas. Penyakit-penyakit tersebut ditangani dengan terapi obat yang sifatnya polifarmasi sehingga dapat menyebabkan risiko terjadi interaksi obat-obat. Penelitian ini dilakukan secara restropektif dengan menggunakan rekam medis pasien usia lanjut dengan penyakit metabolik yang di rawat jalan di Rumah Sakit Umum Pusat Haji Adam Malik Medan. Sebanyak 328 sampel yang termasuk ke dalam kriteria inklusi diperoleh data bahwa jumlah interaksi obat-obat yang terjadi cukup tinggi sebesar 78,96%. Pola mekanisme yang terbanyak adalah farmakokinetik (63,6%) dengan tingkat keparahan yang terbanyak adalah moderat (69,8%). Penelitian ini menunjukan adanya korelasi antara jumlah interaksi dengan jumlah obat (r= 0,728; p= 0,0001), dan jumlah interaksi dengan jumlah diagnosis (r= 0,264; p= 0,0001).Kata kunci: Interaksi obat, penyakit metabolik, polifarmasiPolipharmacy and Drug Interactions in Elderly Patients with Metabolic DiseasesMetabolic disease is a disease that is associated with increasing age such as hypertension, diabetes mellitus, dyslipidemia and obesity. Such diseases are treated with polypharmacy therapy that can cause increased risk of drug interactions. This study was conducted using a restropective method using the medical records of elderly patients with metabolic diseases in outpatient unit of H. Adam Malik General Hospital Medan. A total of 328 samples were included in the inclusion criteria data showed that the numberof drug-drug interactions that occur quite high at 78.96%. The pattern of drug interaction mechanism that most frequently occur is pharmacokinetic (63.6%) and the highest severity was moderate (69.8%). This study shown a correlation between the number of interactions with a number of drugs (r= 0.728; p=0.0001), and the number of interactions with a number of diagnoses (r= 0.264; p= 0.0001).Keywords: Drug-interactions, metabolic-disease, polypharmacy

Effect of Ethanol Extract of Chayote (Sechiumedule.Jacq.Swartz) on the Activity of Glutathione Peroxide (GPx) in House Mice (Musmusculus L) Strain DD Webster Hyperglycemia Induced by Streptozotocin (STZ) Siahaan, Jekson Martiar; Harahap, Urip; Loesnihari, Ricke
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Streptozotocin can cause hyperglycemia in guinea pig through the mechanism of oxidative stress which damages pancreatic b cells. Ethanol extract of chayote can decrease oxidative stress.Â This study aimed to determine the effect of Ethanol Extract of Chayote ((EEBLS) Ekstrak Etanol Buah Labu Siam) on decreasing blood sugar content and increasing the activity of glutathione peroxide enzyme.Â Subjects and Method: This was an experimental study. The samples were using random sampling technique. The control group was using male white mice (Musmusculus L.) Strain DD Webster which randomized into four groups: negative control group, positive control group, group which got EEBLS of 100 mg/kgBB, and group which got EEBLS of 200 mg/kgBB.Results: The result of the research showed that there was significant decrease in blood sugar, compared with the control group. There was insignificant decrease in the activity of glutathione peroxide enzyme, compared with the control group.Conclusion: The conclusion of the research was that EEBLS of 200 mg/kgBB decreased blood sugar content of mice significantly, but there was no significant change in the activity of glutathione peroxide enzyme when EEBLS was given to the mice.Â Â Keywords: streptozotocin, oxidative stress, antioxidant, flavonoidCorrespondence:Â Jekson Martiar Siahaan. Biomedical Science, Faculty of Medicine, North Sumatera University.Indonesian Journal of Medicine (2016), 1(1): 44-49https://doi.org/10.26911/theijmed.2016.01.01.06

Evaluasi Asuhan Kefarmasian terhadap Hasil Terapi dan Kualitas Hidup Pasien Hipertensi Primer di Rumah Sakit Sitepu, Nadroh Br; Harahap, Urip; Nasution, Salli Roseffi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 1 (2014)
Publisher : Indonesian Research Gateway

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The management of hypertension ideally requires collaboration between health professionals which includes in the three aspects: medical care, pharmaceutical care, and nursing care. The purpose of this study was to determine the impact of pharmacist counseling conducted on therapeutic outcomes in systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), blood glucose levels (BGL) period, total cholesterol, and quality of life of patients were measured Short-Form Health Survey 36 (SF-36). This study was conducted at RSUD dr.R.M. Djoelham Binjai involved 60 primary hypertensive patients. Patients were divided into two groups: group counseling and with out conseling. Data were analyzed by independent sample t-test. The result of this study showed significant differences in SBP (p=0.048), BMI(p=0.014), BGL(p=0.002) and total cholesterol (p=0.000) and value of quality of life who received counseling (63.17%) and without counseling (54.80%) with p=0.001. But obtained no significant differences between DBP (p=0.068).Keywords : primary hypertension, pharmaceutical care, counseling.

Evaluasi Asuhan Kefarmasian terhadap Hasil Terapi dan Kualitas Hidup Pasien Hipertensi Primer di Rumah Sakit Harahap, Urip; Nasution, Salli Roseffi; Sitepu, Nadroh Br
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

The management of hypertension ideally requires collaboration between health professionals which includes in the three aspects: medical care, pharmaceutical care, and nursing care. The purpose of this study was to determine the impact of pharmacist counseling conducted on therapeutic outcomes in systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), blood glucose levels (BGL) period, total cholesterol, and quality of life of patients were measured Short-Form Health Survey 36 (SF-36). This study was conducted at RSUD dr.R.M. Djoelham Binjai involved 60 primary hypertensive patients. Patients were divided into two groups: group counseling and with out conseling. Data were analyzed by independent sample t-test. The result of this study showed significant differences in SBP (p=0.048), BMI(p=0.014), BGL(p=0.002) and total cholesterol (p=0.000) and value of quality of life who received counseling (63.17%) and without counseling (54.80%) with p=0.001. But obtained no significant differences between DBP (p=0.068).Keywords : primary hypertension, pharmaceutical care, counseling.

EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) MENURUNKAN KADAR GULA DARAH MENCIT DIABETES Siregar, Ambali Azwar; Harahap, Urip; Mardianto, Mardianto
Jurnal Ilmiah Manuntung Vol 1 No 1 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Diabetes mellitus is one of desease that have a large population and trend to increase. sulfonylurea and biguanide are almost used treatment but have unexpected side effects. The research still necessary to seek alternative medicine, such as Piper crocatum.This study aimed to determine the effect of ethanol extract of red betel leaves on blood sugar levels and body weight of mice (Mus musculus L.) diabetes. This riset was started to produce simplicia and drilled become powders, continued extract with 70% ethanol. The extract was evaporated with rotary evaporator until obtaine crude extract. And then screen it that determine phytochemical. To continued test on tolerance of level of glucose then mice diabetes induced aloxan.In summary, extract of red betle ethanolic has contained alkaloid, quercetin flavonoid, steroid and fenolic compounds and decreased level of glucose in blood mice diabetes. Besides, it can reduce lose of weight symptom.

ANALISA COST OF ILLNESS AKIBAT PENGGUNAAN NSAIDS DI SEBUAH APOTEK DI KOTA MEDAN, INDONESIA Tanjung, Hari Ronaldo; Sarriff, Azmi; Harahap, Urip
Jurnal Ilmiah Manuntung Vol 1 No 1 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Background:Â A drug therapy problem is any undesirable event experienced by a patient which involves, or is suspected to involve drug therapy and that interferes with achieving the desired goals of therapy. Drug Therapy Problems (DTPs) can lead to ineffective pharmacotherapy and may cause drug-related morbidity and mortality.Objective: TheÂ study aimedÂ toÂ estimates the direct medical cost of illness caused by the drug morbidity or mortality related to NSAIDÂ utilizationÂ in a community pharmacy setting at Medan, Indonesia.Method: ThisstudyÂ used 7 (seven) categories probabilities and costs associated with the therapeutic outcomesÂ to estimate the direct medical cost of illness resulting fromÂ morbidity related NSAIDs utilization.Â Direct non medical costs, indirect costs, and intangible costs related to drug-related-morbidity and mortality were not valued in this cost-of-illness analysis.The duration of the study was from July 2009 to October 2010.Result:Â The patient that experienced NSAIDs-relatedÂ morbidity estimated to spend Rp.467.848,- each and Rp.11.696.200,- in total to managing the morbidity. Every Rp.1,- spent on NSAIDs therapy, an additional Rp.1,45,- was estimated to spent in managingÂ morbidity related NSAIDs utilization.Conclusion: This result showedÂ the cost ofÂ illnessrelatedÂ morbidityÂ of NSAIDs utilizationÂ exceeds the cost of the medications themselves

The Significance of Troponin and Ck-Mb in Association with Q-Wave Myocardial Infarction Harahap, Urip; Margata, Linda
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 1 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Abstract. Acute myocardial infarction (AMI) is the global main cause of morbidity and mortality. AMI describes the process of cell death due to prolonged ischemia identified by the appearance of pathological Q-wave in electrocardiogram (ECG). Myocardial cell death does not occur directly after the onset of myocardial ischemia, however, it occurs more than 6 hours after the onset. Thus, certain cardiac markers, such as cardiac troponin and creatinine kinase-MB (CK-MB) which formed in myocardial cell damage, play a vital role in diagnosing AMI. Keywords: Cardiac Biomarker, CK-MB, Diagnosis, Q-wave Myocardial Infarction, Troponin

The Role Of hs-CRP In Predicting The Likelihood Of Coronary Heart Disease Sitepu, Nadroh Br; Harahap, Urip
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 1 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i1.4015

Coronary Heart Disease (CHD) is a disorder of the cardiovascular system, characterized by atherosclerotic lesions. Inflammation is a strong predictor for coronary heart disease. High sensitivity C-Reactive Protein (hs-CRP) is an important biomarker, synthesized in the liver, can predict the severity of CHD. If the hs-CRP level is found to be low 3 mg / L, a person has the potential for severe vascular risk. Therefore, hs-CRP can be used as a predictor of primary CHD prevention, especially if the hs-CRP level is still low.

Anti-Acne Activity From Biocellulose Mask Formula Containing (Aloe Vera (L.) Burm.F) Essence Combined With Vitamin E Fitri, Raissa; Reveny, Julia; Harahap, Urip; Dharmawan, Hariyadi; Nasri
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i1.5382

Abstract. Biocellulose mask sheet is a new found pharmaceutical cosmetic design that widely commercial. Mostly due to itâ€™s biodegradable properties, provide an eco-friendly waste. Combination of Aloe vera essence (AE) and Vit E to provide and determine itâ€™s respective anti-acne properties in biocellulose mask form. Formulation of biocellulose mask with the help of Acetobacter xylinum bacteria varied with different formulae: F1 (Vitamin E 1%), F2 (E 2.5 %), F3 (AE 5%), F4 (AE 2.5%+Vit E 1%) and F5 (AE 5%+Vit E 1%) followed antimicrobials test with common acne bacteria by diffusion disk against Propionibacterium acne (PAC) ATCC 6919 and Pseudomonas aeruginosa (PAA) ATCC 27853. Study revealed that each formulae design F1; F2; F3; F4; F5 tested against PAC diffusion disk resulted 7.86; 11.67; 10.13; 112.10; 10.33 mm respectively. As for PAA diffusion disk resulted 7.76; 11.63; 10.33; 11.67; 11.00 mm respectively. Biocellulose mask containing combination of AE 2.5% and Vit E (F4) would provide the best anti-acne activity amongst other formulae.

Prevention of Pesticide Toxicity Risk through the Farmer Community Movement to Resolve Toxicity Mahyuni, Eka Lestari; Harahap, R. Hamdani; Harahap, Urip; Nurmaini
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 2 (2020): ABDIMAS TALENTA : Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Pesticide toxicity is a phenomenon that needs to be prevented, which is generally caused by the risky behavior of using pesticides. This PPM activity is one of the community empowerment activities to reduce the risk of pesticide toxicity through the GEMPAR (Gerakan Masyarakat Petani Atasi Racun) action. GEMPAR consists of eight farmer movements to prevent the risk of toxicity due to pesticides used. The eight GEMPAR actions were applied by farmers with promotional and educational methods through the GEMPAR demonstration activities. The demonstration implementation method is presented by the farming community which is divided into three areas in Sumber Mufakat Village, namely Berhala, Simpang Sumbul, and Pasar Sumbul. Demonstrations from these three areas were contested as a form of appreciation for the community so that they could motivate the community to participate in preventing the risk of pesticide toxicity. The demonstration that displayed the messages of the eight GEMPAR movements was carried out well. Each demonstration gives special characteristics either through songs or slogans related to preventing the risk of toxicity. The community became very enthusiastic about the demonstration which could increase the participation of the farming community to use better and healthier pesticides sustainably.

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