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All Journal Buletin Kedokteran dan Kesehatan Prima Jurnal Mahasiswa Ilmu Kesehatan
Lubis, Asyrun Alkhairi
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : Buletin Kedokteran dan Kesehatan Prima

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Skrinning fitokimia komponen bioaktif Parem Karo Sembiring, Novitaria Br.; Lubis, Asyrun Alkhairi; Karo, Reh Malem Br; Hidayat, Andri
Buletin Kedokteran & Kesehatan Prima Vol. 2 No. 2 (2023): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v2i2.4798

Abstract

Param Karo atau disebut juga Kuning Bergeh, memiliki khasiat untuk menurunkan suhu tubuh ketika demam. Berdasarkan wawancara dengan pembuat param Karo, di Kelurahan Pekan Bahorok, Sumatera Utara, sediaan ini terbuat dari buah pala (Piperis Nigri Fructus), jahe (Zingiberis Officinalis Rhizoma), bangle (Zingiber purpureum), lempuyang (Zingiber cassumunar), kencur (Kaemferia galanga), temulawak (Curcuma xanthoriza), temu kunci (Boesenbergia pandurata), dan tepung beras (Oryza Sativa) yang dihaluskan, kemudian dibentuk bulat-bulat ukuran kecil. Penelitian ini bertujuan untuk mengidentifikasi metabolit sekunder Param Karo yang belum pernah diteliti. Metode penelitian ini eksperimental dengan menguji metabolit sekunder param Karo menggunakan reagen-reagen skrinning fitokimia. Hasil pengujian skrinning fitokimia param Karo positive mengandung alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Sehingga dapat disimpulkan param Karo mengandung metabolit sekunder seperti alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Meskipun, bahan-bahan dalam pembuatan param Karo sudah melewati proses pemanasan, komponen senyawa bioaktif khususnya metabolit sekunder tidak rusak dan dapat dipertahankan.
The effect of gelagah stem extract on blood glucose levels in male white rats induced with alloxan Simatupang, Veronica Triwindari; Lubis, Asyrun Alkhairi; Nasution, Ali Napiah; Lumbantobing, Christina JRE; Fioni, Fioni; Rahimi, Armon
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5218

Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to insulin deficiency, insulin resistance, or both. This study aimed to investigate the effects of gelagah stem extract (Saccharum spontaneum L.) on blood glucose levels in male Sprague-Dawley rats induced with alloxan. Experimental rats were divided into six groups: a normal control group, a negative control group (administered 100 mg/kg body weight alloxan), a positive control group (administered 5 mg/kg body weight glibenclamide), and three treatment groups administered gelagah stem extract at doses of 100, 200, and 400 mg/kg body weight. Results showed that all doses of gelagah stem extract significantly reduced blood glucose levels in alloxan-induced diabetic rats. Statistical analysis (Post hoc LSD) confirmed that the decrease in blood glucose levels was significantly different between the treatment groups and the negative control group (p < 0.05).
Co-Authors Andri Hidayat, Andri Br Ginting, Anissa Destryana Fioni, Fioni Lumbantobing, Christina JRE Nasution, Ali Napiah Rahimi, Armon Reh Malem br Karo Sembiring, Novitaria Br. Simatupang, Veronica Triwindari