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Fioni, Fioni
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Efektivitas madu sebagai gastroprotektif pada tikus putih yang diinduksi aspirin bedasarkan hasil histopatologi Meutia, Rena; Razoki, Razoki; Halim, Binarwan; Nasution, Chairul Radjab; Tarigan, Antje Irmella; Fioni, Fioni; Nardi, Leo
Buletin Kedokteran & Kesehatan Prima Vol. 1 No. 2 (2022): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (553.15 KB) | DOI: 10.34012/bkkp.v1i2.2689

Abstract

Tukak lambung merupakan kerusakan jaringan mukosa, sub mukosa sampai lapisan otot lambung. Salah satu penyebabkan tukak lambung yaitu hipersekresi asam lambung sehingga terjadi kerusakan mukosa. Madu memiliki efek gastroprotektif, karena di dalam madu terdapat senyawa flavonoid, vitamin E, asam askorbat, dan katalase, Tujuan penelitian ini adalah untuk mengetahui aktivitas gastroprotektif akibat pemberian madu pada tikus yang diinduksi aspirin. Metode yang digunakan madu pada masing-masing pemberian tunggal diberikan 3 variasi kosentrasi yaitu madu 0,5; 0,75; dan 1 ml/kgbb. Parameter pengamatan meliputi biometrik makroskopis (jumlah tukak, pH tukak dan indeks tukak) dan mikroskopis (uji histopatologi). Bedasarkan hasil yang diperoleh bahwa bedasarkan pengamatan makroskopis terhadap perlakuan tunggal menunjukkan bahwa pemberian madu sebesar 1 ml/kgbb menunjukkan efek gastroprotektif dari kosentrasi lainnya. Kesimpulan: uji histopatologi pada dosis yang memiliki efek gastroprotektif dapat mengembalikan kohesi sel mukosa yang sebelumnya telah rusak akibat erosi.
The effect of gelagah stem extract on blood glucose levels in male white rats induced with alloxan Simatupang, Veronica Triwindari; Lubis, Asyrun Alkhairi; Nasution, Ali Napiah; Lumbantobing, Christina JRE; Fioni, Fioni; Rahimi, Armon
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5218

Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to insulin deficiency, insulin resistance, or both. This study aimed to investigate the effects of gelagah stem extract (Saccharum spontaneum L.) on blood glucose levels in male Sprague-Dawley rats induced with alloxan. Experimental rats were divided into six groups: a normal control group, a negative control group (administered 100 mg/kg body weight alloxan), a positive control group (administered 5 mg/kg body weight glibenclamide), and three treatment groups administered gelagah stem extract at doses of 100, 200, and 400 mg/kg body weight. Results showed that all doses of gelagah stem extract significantly reduced blood glucose levels in alloxan-induced diabetic rats. Statistical analysis (Post hoc LSD) confirmed that the decrease in blood glucose levels was significantly different between the treatment groups and the negative control group (p < 0.05).
Analisis kadar zat besi pada sari kedelai kemasan dengan metode spektrofotometri UV-VIS br Karo, Reh Malem; Sinurat, Jhon Patar; Fioni, Fioni; Fibrini, Dewi
Jurnal Prima Medika Sains Vol. 3 No. 2 (2021): Desember
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v3i2.2038

Abstract

Latar belakang: Kedelai adalah hasil pangan jenis kacang-kacangan yang sangat kaya akan nutrisi yang bermanfaat bagi kesehatan manusia. Tujuan: Untuk mengetahui keberadaan zat besi dan kadar zat besi dalam sari kedelai. Metode: Analisis kualitatif menggunakan pereaksi NaOH, K4[Fe(CN)6] dan K3[Fe(CN)6] dan analisis kuantitatif menggunakan spektrofotometer UV-Visibel pada panjang gelombang 248.3 nm. Hasil: Sari kedelai mengandung zat besi yang dibuktikan melalui analisis kualitatif menggunakan pereaksi NaOH, K4[Fe(CN)6] dan K3[Fe(CN)6] yang menghasilkan masing-masing endapan hijau, biru dan coklat yang artinya mengnadung zat besi. Persamaan regresi linear larutan standar besi adalah Y = 0.0154x  +  0.1555 dengan korelasi (R2) sebesar 0.9981. Kadar zat besi dalam sari kedelai adalah 56.48 mg/ml dan termasuk dalam kelompok produk yang memiliki kadar zat besi yang cukup tinggi. Kesimpulan: Sari kedelai mengandung zat zat besi dengan kadar sebesar 56.48mg/ml.
Effectiveness of green betel leaf extract cream in healing cut wounds Aulia, Hilda Rafni; Wienaldi, Wienaldi; Fioni, Fioni
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4399

Abstract

Green betel leaf (Piper betle L.) is widely used in the healing of cut wounds. The aim of this study was to investigate the efficacy of green betel leaf extract cream in the healing of cut wounds on the skin of white Wistar rats. The design employed was a pre-test post-test with a control group design and a sample size of 20 white rats divided into four groups. Betel leaf extract was prepared using the maceration method, while a cream preparation of betel leaf extract was prepared using the oil-in-water emulsion type (M/A). Macroscopic histopathological evaluation was performed by examining fibroblast growth. A one-way analysis of variance (ANOVA) test (p < 0.05) was used to determine the difference between groups, and a post hoc least significant difference (LSD) test was used to analyze which treatment group had the greatest efficacy. Technical terms were explained upon first use, and the language used was clear, objective, and value-neutral to improve academic quality. The text was free from grammatical errors, spelling mistakes, and unnecessary jargon. A one-way analysis of variance (ANOVA) test (p < 0.05) was used to determine the difference between groups, and a post hoc least significant difference (LSD) test was used to analyze which treatment group had the greatest efficacy. The study revealed a substantial difference in the average wound healing rates between the control group (P0) and treatment groups P1, P2, and P3. This is due to the lack of active substances in the control group (P0), which aids in accelerating the wound healing process. Notably, the 15% green betel leaf extract cream demonstrated superior efficacy in healing wounds in white rats compared to the 10% and 25% green betel leaf extract creams. The results indicated no significant difference between the application of 15% and 25% green betel leaf extract cream. This is due to the fact that secondary metabolite compounds present in the extract produce a healing effect on wounds at these particular levels. However, lower concentrations only act as microorganism inhibitors, rendering them less effective for promoting wound healing.
Co-Authors Aulia, Hilda Rafni Binarwan Halim Fibrini, Dewi Lubis, Asyrun Alkhairi Lumbantobing, Christina JRE Meutia, Rena Nardi, Leo Nasution, Ali Napiah Nasution, Chairul Radjab Rahimi, Armon Razoki, Razoki Reh Malem br Karo Simatupang, Veronica Triwindari Sinurat, Jhon Patar Tarigan, Antje Irmella Wienaldi, Wienaldi