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All Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan The Journal of Society Medicine (JSOCMED)
Tamasse, Jumraini
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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PENGARUH INTERVENSI REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION TERHADAP FUNGSI SENSORIMOTOR PADA PASIEN STROKE ISKEMIK SUBAKUT Tamasse, Jumraini; A. Zuljumadi Adma; Muhammad Akbar; Irfan Idris; Andi Kurnia Bintang; Yudy Goysal
Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 1 (2024): April
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i1.163

Abstract

Stroke adalah gangguan akut perfusi serebral dan penyebab kecacatan pada populasi di seluruh dunia. Stroke iskemik subakut adalah fase stroke berdasarkan waktu pemulihan. Untuk mengatasi permasalahan fungsi sensorimotor akibat stroke diperlukan neurorestorasi. Strategi baru dalam bidang neurorestorasi berupa neuroinvasive brain stimulation (NIBS), salah satu modalitasnya adalah repetitive transcranial magnetic stimulation (rTMS). Penelitian sebelumnya menunjukkan bahwa rTMS telah menunjukan berbagai manfaat terhadap perbaikan fungsi sensorimotor pasca stroke, namun, masih terdapat hasil yang bervariasi. Penelitian ini merupakan jenis penelitian eksperimental dengan desain pre-test post-test control group. Data demografi serta tanda dan gejala pasien diperoleh dari anamnesis dan pemeriksaan fisik. Protokol rTMS menggunakan stimulus eksitasi frekuensi 10 Hz, 740 pulse selama 7 menit 10 detik dan stimulus inhibisi frekuensi 1 Hz, 1200 pulse selama 19 menit 59 detik sedangkan penilaian terhadap fungsi sensorimotor menggunakan skor fugl-mayer assesment upper extremity dan lower extremity (FMA-UE dan FMA-LE) sebelum dan setelah perlakuan. Uji Wilcoxon dan uji Mann Whitney dilakukan untuk analisis statistik. Signifikansi statistik didefinisikan sebagai nilai p <0,05. Terdapat pengaruh intervensi repetitive Transcranial Magnetic Stimulation terhadap fungsi motorik dimana fungsi motorik pada UE perlakuan (16,33±8,61) dan UE kontrol (2,80±1,42), nilai p 0,000*.
High Density Lipoprotein (HDL) Level and Blood Urea Nitrogen (BUN)/Creatinin Ratio Relationship with One-Month Outcome in Acute Ischemic Stroke Patients Habib Djarkoni, Ilham; Iqbal Basri, Muhammad; Akbar, Muhammad; Hamid, Firdaus; Kurnia Bintang, Andi; Tamasse, Jumraini
Journal of Society Medicine Vol. 2 No. 12 (2023): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i12.112

Abstract

Introduction: Stroke has caused around 15.5% of all deaths. Evaluation of factors that worsen clinical outcomes is necessary to avoid complications such as renal dysfunction and secondary dyslipidaemia. This study aims to determine the relationship between increasing serum HDL levels and blood urea nitrogen–serum creatinine ratio (BUN/Cr) on clinical outcomes of acute ischemic stroke. Method: Prospective cohort study was used with subjects being first-onset acute ischemic stroke patients. Demographic, clinical data, and assessment of BUN/Cr and HDL ratios were collected. Subjects were divided into good clinical outcome (mRS 0-2) and poor clinical outcome (mRS 3-6) groups, and then analysed using multiple linear regression multivariate analysis with confidence interval of 95%. Results: 60 participants met the inclusion criteria. There was a significant relationship between serum BCR levels and poor clinical outcomes (p <0.001) relationship between serum HDL levels and poor clinical outcomes also shown significances (p <0.001) Mean BCR in good and poor clinical outcomes of acute ischemic stroke were (17.08±30.13) and (29.35±67.30) respectively. Mean HDL in good and poor clinical outcomes were (39± 62) and (41 ± 92) respectively.  A multiple linear regression analysis showed a positive correlation (p <0.001) between increasing Serum HDL levels and Bun/Cr ratio simultaneously to poor clinical outcomes in acute ischemic stroke patients. The Cut-off point was 20.9 for BUN to creatinine ratio and 46 mg/dL at serum HDL. Both of BUN/Cr ratio and HDL were shown high specificity and could be used as predictors of clinical outcome in acute ischemic stroke patients. Conclusion: Increased BUN/Cr ratio and increased serum HDL levels were associated with clinical outcomes in patients with acute ischemic stroke.
Co-Authors A. Zuljumadi Adma Andi Kurnia Bintang Habib Djarkoni, Ilham Hamid, Firdaus Iqbal Basri, Muhammad Irfan Idris Kurnia Bintang, Andi Muhammad Akbar Muhammad Akbar Yudy Goysal