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Des Suryani
Universitas Muhammadiyah Sumatera Utara
Religion Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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PENGARUH PEMBERIAN MINUMAN BERENERGI YANG MENGANDUNG ASPARTAM TERHADAP GAMBARAN HISTOPATOLOGI CEREBELLUM TIKUS JANTAN (Rattus norvegicus L.) Ritonga, Annisa Qarunia; Suryani, Des
JURNAL IBNU SINA BIOMEDIKA Vol 1, No 1 (2017)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (374.902 KB) | DOI: 10.30596/isb.v1i1.1090

Abstract

Latar belakang. Minuman berenergi yang mengandung aspartam jika dikonsumsi secara berlebihan berpotensi merusak sel saraf, dan dapat menyebabkan kerusakan histologi cerebellum.Tujuan. Untuk mengetahui “Pengaruh Pemberian Minuman Berenergi yang Mengandung Aspartam terhadap Gambaran Histopatologi Cerebellum Tikus Jantan (Rattus norvegicus L.)”.Metode. Penelitian eksperimental dengan metode Post test Only With Control Group Design yang menganalisis histopatologi cerebellum menggunakan histoteknik parafin blok, dengan pewarnaan HE dan mikroskop cahaya serta mengumpulkan data dengan pengamatan langsung gambaran histopatologi cerebellum. Uji hipotesis menggunakan uji One-Way ANOVA yang dilanjutkan dengan uji Post Hoc Benferroni.Hasil.  Kepadatan sel purkinje normal pada uji ANOVA didapatkan  perbedaan signifikan (p=0,000). antara kontrol negatif (KN) dengan perlakuan (P1,P2) dan kontrol positif (KP1,KP2) terdapat ada perbedaan signifikan (p<0,05) dan tidak ada perbedaan signifikan (p>0,05) antara kontrol negatif (KN) dengan perlakuan (P1,P2) dan kontrol positif (KP1,KP2) dari sel purkinje yang patologis tikus jantan (Rattus norvegicus L ). Kesimpulan. Minuman berenergi yang mengandung aspartam dapat menyebabkan kerusakan berupa penurunan kepadatan sel purkinje cerebellum dan sel purkinje patologis pada kelompok perlakuan (P1,P2) dan kontrol positif (KP1,KP2). Kata kunci : Minuman berenergi, aspartam, sel purkinje, histopatologi cerebellum. 
PENGARUH PEMBERIAN EKSTRAK AIR TEBU HITAM (Saccharum officinarum L.) TERHADAP KADAR KOLESTEROL TOTAL SERUM MENCIT (Mus musculus) YANG DIINDUKSI DIET TINGGI KOLESTEROL Hidayati, Nurul; Suryani, Des
JURNAL IBNU SINA BIOMEDIKA Vol 2, No 2 (2018)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.058 KB) | DOI: 10.30596/isb.v2i2.2599

Abstract

AbstrakLatar Belakang. Dislipidemia adalah keadaan abnormal lipid dan lipoprotein dalam darah. Obat-obatan yang digunakan sebelumnya seperti statin, diketahui memiliki beberapa efek samping seperti myositis, kelemahan otot, insomnia, peningkatan enzim hati dan rhabdomyolysis. Octacosanol dapat menurunkan sintesis kolesterol dengan menghambat HMG-CoA reductase. Octacosanol adalah campuran alami dari alkohol jenuh rantai panjang yang dapat ditemukan di tebu, gandum, dan bekatul. Metode. Studi eksperimental, tikus dibagi menjadi 5 kelompok: kelompok kontrol negatif (diet standar), kontrol positif (diet kolesterol tinggi), dan kelompok perlakuan 1, 2 dan 3 (diet kolesterol tinggi juga 0,25 cc, 0,35 cc dan 0, 50 cc ekstrak tebu hitam). Perawatan selama 30 hari dan darah diambil pada akhir penelitian untuk pemeriksaan kadar kolesterol total serum. Hasil. Ada perbedaan yang signifikan antara kadar kolesterol total dari kelompok kontrol positif dan kelompok perlakuan, nilai p = 0,00 itu membuktikan bahwa ekstrak tebu hitam berpengaruh terhadap penurunan kadar kolesterol total tikus. Namun, hasil analisis berat badan tikus meningkat secara signifikan, nilai p = 0,00 sehingga tidak boleh diberikan pasien dengan dislipidemia dengan obesitas. Kesimpulan. Hasil penelitian ini menunjukkan bahwa pemberian ekstrak tebu hitam dapat menurunkan kadar kolesterol total serum dengan efek samping meningkatkan berat badan tikus. Kata kunci: total kolesterol, dislipidemia, octacosanol, ekstrak tebu hitam
Hubungan Kadar Low Density Lipoprotein Dengan Gangguan Pendengaran Sensorineural Nurfadhilah Amini Nasution; Muhammad Edy Syahputra Nasution; Siti Masliana Siregar; Des Suryani
Jurnal Kesehatan Panrita Husada Vol 5 No 2 (2020)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (Stikes Panrita Husada Bulukumba)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37362/jkph.v5i2.372

Abstract

Abnormalities of lipid metabolism in hyperlipidemia are the cause of atherosclerotic plaque in the inner ear and cranial nerves VIII, which can cause sensorineural hearing loss. Based on previous research, this theory is still questionable. Objective: To determine the relationship of LDL levels with sensorineural hearing loss. Method: This study is an analytic study with a cross-sectional approach. The research sample was taken based on a categorical descriptive formula with a large sample of 38 people. The data obtained is the result of laboratory tests, physical examination of the ears, nose and throat and audiometry examination of pure tone. This research was conducted at Medan Haji General Hospital and Putri Hijau Hospital II Medan. The number of research subjects was determined using consecutive sampling techniques. Data were analyzed using chi square test statistics. Results: There was a significant correlation of LDL levels with sensorineural hearing loss with a value of p = 0.001. The highest age in this study was 50-60 years of age, the most sex was female, the highest degree of hearing loss was moderateConclusion: There is a significant relationship between LDL levels with sensorineural hearing loss. Keywords: Audiometry, Hearing Loss, Sensorineural Hearing Loss, Low Density Lipoprotein, Lipid Profile
PENGETAHUAN DAN PENERAPAN GERMAS PIS-PK PADA KELUARGA BINAAN KESEHATAN FAKULTAS KEDOKTERAN UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA TAHUN 2020 HANNY RAHMI LUBIS; DES SURYANI
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

In an effort to improve the quality of health in Indonesia, the president initiated a national movement, namely GERMAS. Theimplementation of GERMAS activities starts from the family level as the smallest part of the community. In order to supportthis government movement, the UMSU Faculty of Medicine also created a program called the health assisted familyprogram. The program, which has been running since 2013, aims students to educate the target family to live healthier life.However, so far there has been no analysis of the results of this activity, both regarding the knowledge and also the dailyapplication of GERMAS PIS-PK by the assisted families. Therefore, the researcher wants to assess the knowledge andapplication of the family and see the relationship between them. To determine the relationship between the knowledge of thetarget family community on GERMAS PIS-PK and their application to the program. Observational research with crosssectional design in the health assisted families of FK UMSU class of students 2017. Research data were obtained fromprimary data using a knowledge questionnaire about GERMAS PIS-PK and a questionnaire on the application of GERMASPIS-PK. Then do the analysis with the Fisher test. There were 28 families (96.6%) with good knowledge and there were 28families (96.6%) who had applied GERMAS PIS-PK. The results of the Fisher test showed that there was a significantrelationship between the knowledge of the assisted families about GERMAS PIS-PK and the application of GERMAS PIS-PKwith a value of P = 0.034 (p <0.05). The families who have good knowledge about GERMAS PIS-PK also apply GERMASPIS-PK well in their daily life.
PERBANDINGAN EFEKTIVITAS NEFROPROTEKTOR EKSTRAK JINTAN HITAM (NIGELLA SATIVA) DENGAN EKSTRAK TEMULAWAK (CURCUMA XANTHORRHIZA) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS (RATTUS NOVERGICUS) YANG DIINDUKSI PARASETAMOL KARTIKA HANDAYANI; DES SURYANI; HUMAIRAH MEDINA LIZA LUBIS
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Over-use of paracetamol can cause nephrotoxicity. Black cumin and curcuma contain antioxidants that can ward off freeradicals produced by paracetamol metabolism. To compare the effectiveness of nephroprotector of black cumin extract andcurcuma extract on the histopathological picture of rats induced by paracetamol. True experimental, Post Test Only ControlDesign. 24 rats were divided into 4 groups: negative control standard diet and aquades, positive group paracetamol dose500 mg / kgBB, treatment 1 extract of black cumin extract 500 mg / kgBB, and treatment 2 curcuma extract 500 mg / kgBB.After 30 minutes P1 and P2 were given a dose of paracetamol 500 mg / kg. Rats were dissected for kidney removal andhistopathological preparations were made. Degeneration, necrosis and bleeding of the proximal tubules were assessed byscoring, comparison of scores between groups was assessed by the kruskal wallis test. There were nephroprotector effectsof black cumin and curcuma, with the same effectiveness on kidney damage induced by paracetamol. Black cumin can bedeveloped further as a nephroprotector.
PENGARUH KEPATUHAN PROTOKOL KESEHATAN PANDEMI COVID - 19 TERHADAP STRES DAN RELIGIUSITAS MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA MUHAMMAD IQBAL; DES SURYANI; NANDA SARI NURALITA; PINTA PUDIYANTI SIREGAR
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

COVID-19 is an infectious disease outbreak that has emerged since January 30, 2019 and has been called a public healthemergency by WHO. In order to avoid community transmission, it is recommended to comply with the health protocolestablished by the government. Many of the impacts of the health protocol are felt by the community, especially students,namely academic stress. The level of adherence to the health protocol itself can be related to the level of one's religiosity.To determine the effect of compliance with the COVID-19 health protocol on stress and religiosity of students at the Facultyof Medicine, University Muhammadiyah of Sumatra Utara. This study is a cross-sectional study. The number of sampleswas calculated using the Slovin formula totaling 164 people. Hypothesis test used is Chi Square test. Data were collectedbased on a questionnaire, namely DASS-42, adherence to health protocols and the Religiosity Scale. The results showedthat during the pandemic the level of good student compliance was 52.4% and those who did not comply were 47.6% with anormal stress level of 68.3% , mild stress 15.2%, moderate stress 9.8%, heavy stress 4.9% and very severe stress 1.8%.The level of religiosity of students during the pandemic with good religiosity was 51.2% and those that were lacking were48.8%. Based on the Chi Square test, it was found that the relationship between health protocol compliance with stress (p =0.001) and religiosity (p value = 0.001) but after the Kendall's tau correlation test, the value of p = 0.001 and p = 0.001 wasfound (it seems that there is a positive relationship with very strong correlation. weak. Adherence to implementing healthprotocols has a positive correlation with religiosity and student stress, but the correlation is weak. There is a positiveinfluence between compliance with the COVID-19 protocol on stress and religiosity.
HUBUNGAN KEPATUHAN MENJALANKAN PROTOKOL KESEHATAN PANDEMI COVID - 19 DENGAN PENGETAHUAN COVID - 19 DAN PERSEPSI COVID-19 PERAWAT DI RS AVICENNA BIREUEN, KOTA BIREUEN ACEH WIDYA AFIFAH; DES SURYANI; IKHFANA SYAFINA; IKA NOPA
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Coronavirus Disease 2019 (COVID-19) is a respiratory disease caused by Severe Acute Respiratory Disease SyndromeCoronavirus-2 (SARS-CoV-2). Health workforce efforts to break the chain of virus transmission in Health Service Facilities.Therefore it is very important to apply knowledge and perceptions of transmission of COVID-19. Some literature states thatthere is a relationship between one's compliance with knowledge and perception. However, other researchers said there wasno linkage of deficiencies, so researchers wanted to see which one was most appropriate about this. To determine therelationship between nurses' compliance implementing COVID-19 Pandemic Health Protocol with COVID-19 knowledgedand perception of COVID-19.. Caterogical analysis using cross sectional design. Nurses working at Avicenna Bireuen Hospitalin 2020. The research data were obtained from primary data using a COVID-19 Health Protocol compliance questionnaire,knowledge and perception questionnaire of COVID-19. Then do to analysis with the Chi Square test. The results of ChiSquare test showed that there was a significant relationship between nurses' compliance implementing COVID-19 pandemichealth protocol with knowledge of COVID- 19 wih a value of P=0.004 (p<0.05) and perceptions of COVID-19 with a value ofP=0.012 (p<0.05). Nurses who adhere to the COVID-19 pandemic health protocol have good knowledge of COVID-19 andgood perceptions of COVID-19.
EVALUASI HASIL INVESTIGASI KONTAK SERUMAH PADA PASIEN TUBERKULOSIS DI KOTA MEDAN MAULIDA SHAFI; ISTI ILMIATI FUJIATI; ELMAN BOY; DES SURYANI
JURNAL ILMIAH SIMANTEK Vol 5 No 2 (2021): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

This study aims to determine the distribution of TB suspects based on demographics, symptoms, and risk factors and therelationship between household contact with TB suspects. This study used a descriptive method with cross sectional design.Data were processed using SPSS Chi-Square test. The results showed that the frequency of TB suspects in people whocontact with TB patients by age was at the age of 21-40 years, based on gender the most frequency was found in males 41people (62.1%). Based on symptoms obtained frequency the most common symptom was cough (89.4%), based on the riskfactor for the most frequency in smokers (19.7%), and based on the relationship of household contact with suspected TBusing the Chi-square statistical test showed that the probability value (p) <0.05 (p = .000). This means that at the 95%significance level with ɑ = 0.05, there is a significant relationship between household contact with TB patients with suspectedTB. From the results of the study it was found that the frequency of TB suspicion among people who had household contactwith TB patients based on age at most was in the age group of 21-40 years totaling 19 patients (28.8%).
GAMBARAN FOTO TORAKS PASIEN PENYAKIT PARU YANG MENGALAMI HEMOPTISIS PERIODE FEBRUARI - JUNI 2018 DI RSUD DR. PIRNGADI MEDAN RIZKY NURDIANTY; IKHFANA SYAFINA; DEDY DWI PUTRA; DES SURYANI
JURNAL ILMIAH SIMANTEK Vol 5 No 3 (2021): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Hemoptysis is a symptom of removal of blood from mouths that are filled with a feeling of wanting to cough hematemesis ablood drain, black which is not and weal. To find out the picture of the chest X ray of patients with pulmonary disease whoexperienced symptoms of hemotysis in February 2018 – june 2018 at Dr. Pirngadi Medan. The type to be used in thisresearch is descriptive research and cross sectional research design. study. Population is patient of polyclinic of lung atRSUD Dr. Pirngadi Medan. The sample in this study is the medical record data from febuary 2018 – june 2018 in patients inthe pulmonary clinic RSUD Dr. Pirngadi Medan. The results of chest X-ray images in lung patients with most hemoptysissymptoms were infiltrates of 40 (75.5), the most gender who experience symptoms of hemoptysis are men as many as 40(75.5%), the highest age who experience symptoms of hemoptysis is 21-30 years as many as 22 (41.5%), the most lungdiagnosis of hemoptysis is 30 pulmonary tuberculosis (56.6%). There is a picture of chest X-ray infiltrates more common inlung disease patients with hemoptysis symptoms.
PENGARUH PEMBERIAN MINUMAN BERENERGI YANG MENGANDUNG ASPARTAM TERHADAP GAMBARAN HISTOPATOLOGI RENAL TIKUS JANTAN (Rattus norvegicus L.) Cindy Mentari; Des suryani
ANATOMICA MEDICAL JOURNAL | AMJ Vol 1, No 3 (2018)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.776 KB) | DOI: 10.30596/anatomica

Abstract

ABSTRACTBackground: Energy drinks containing aspartame are commonly consumed by the public, the use of aspartame in energy drinks causes controversy regarding its safety against kidneys especially when consumed in excess. Objective: This study aimed to determine the effect of energy drinks containing aspartame on histopathology renal male rats (Rattus norvegicus L .) ". Method: Invivo experimental study on mice with posttest only with control group design. Rats were divided into 5 groups: negative control group (KN) which was only given aquades, positive control 1 (KP1) given ADI dose aspartame (50 mg / kg / day), positive control 2 (KP2) given toxic dose aspartame (75 mg / kgbb / day), treatment 1 (P1) given ADI dose of energy drinks aspartame (50 mg / kg / day), and treatment 2 (P2) given doses of aspartame doses of energy (75 mg / kg / day). and treated for 28 days. Renal histopathology was analyzed qualitatively. Glomerular and tubulus proximal degeneration degree data were analyzed using the Kruskal-walis test and Mann-Whitney post Hoc test. Results: Giving energy drinks containing aspartame caused glomerular and renal proximal tubular degeneration. There is a difference in the level of kidney damage between mice given ADI dose aspartame and mice given aspartame exceeding the ADI dose (p <0.05). There was no difference in the level of proximal tubular damage between mice given aspartame doses in excess of ADI with mice given energy drinks contains aspartame both at ADI doses and in doses exceeding the ADI level (p> 0.05). Conclusion: Energy drinks containing aspartame cause hydrophic degeneration in the glomerulus and proximal tubules of male rats. Other contents in energy drinks may aggravate the conditions of hydrophic degeneration in the glomerular and proximal tubular of  rat that are given energy drinks according to ADI doses, especially if given in doses that exceed ADI doses 
Co-Authors AQILAH HANIFA Balemun Kaisar Harahap Cindy Mentari Debby Mirani Lubis DEDY DWI PUTRA Eka Febriyanti ELMAN BOY HANNY RAHMI LUBIS Hidayati, Nurul Hildaini Fatma Tanjung Humairah Medina Liza Lubis Huwainan Nisa Nasution Ika Nopa IKHFANA SYAFINA ISTI ILMIATI FUJIATI KARTIKA HANDAYANI MAULIDA SHAFI Muhammad Edy Syahputra Nasution Muhammad Iqbal Nuralita, Nanda Sari Nurfadhilah Amini Nasution Nurhakiki Zahara Arif Octari Auliati Ritonga, Annisa Qarunia RIZKY NURDIANTY Shinta Damayanti Siregar, Pinta Pudiyanti Vici Vitricia Melja WIDYA AFIFAH