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All Journal Jurnal Kesehatan Andalas Jurnal Kedokteran dan Kesehatan JURNAL IBNU SINA BIOMEDIKA Jurnal Kesehatan Bina Generasi MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Medica Hospitalia
Wahab, Zulfachmi
FK Universitas Muhammadiyah Semarang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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PERUBAHAN KADAR HEMOGLOBIN DAN NILAI ENZIM AMINOTRANSFERASE PADA TERAPI ANTIRETROVIRAL LINI PERTAMA Ratnaningrum, Kanti; Wahab, Zulfachmi; Augatha, Arrafli Bagas
JURNAL IBNU SINA BIOMEDIKA Vol 2, No 1 (2018)
Publisher : UNIVERSITAS MUHAMMADIYAH SUMATERA UTARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (553.6 KB) | DOI: 10.30596/isb.v2i1.1832

Abstract

Pendahuluan: Terapi Anti Retroviral (ARV) lini pertama (Human Immunodeficiency Virus) HIV masih digunakan sebagai pilihan utama dalam pengobatan HIV. Penggunaan ARV memerlukan pemantauan nilai laboratorium untuk meghindari efek samping akibat terapi tersebut. Sedikitnya informasi tentang efek samping terapi ARV dan semakin banyaknya kasus pasien HIV menyebabkan peneliti ingin mengetahui jumlah penurunan kadar hemoglobin dan peningkatan nilai enzim amino transferase pada pasien HIV dengan terapi ARV lini pertama kombinasi duviral dan neviral.Metode: Penelitian ini merupakan studi observasional analitik dengan pendekatan cross  sectional, dengan metode consecutive  sampling. Data merupakan data sekunder pasien HIV di RSUD Ambarawa. Kriteria inklusi berusia ≥18 tahun, menjalani 1 tahun pengobatan dalam kurun waktu 2011-2015 dengan kombinasi duviral dan neviral. Data dianalisis menggunakan uji T berpasangan untuk kadar hemoglobin dan uji chi square untuk nilai enzim aminotransferase.Hasil: Dari 37 sampel, terdapat sigifikansi antara terapi anti retroviral lini pertama terhadap perubahan kadar hemoglobin (p=<0,001) dengan delta penururan 3,29 mg/dl dan nilai enzim aminotransferase yaitu nilai SGPT (p=<0,001) dengan delta peningkatan 14,09 IU serta SGOT (p=0,021) dengan delta peningkatan 11,40 IU.Simpulan: Terjadi penurunan kadar hemoglobin sebesar 3,29 mg/dl, peningkatan nilai enzim aminotransferase sebesar 14,09 IU pada SGPT serta 11,40 IU pada SGOT setelah terapi ARV lini pertama.
Central and Peripheral Obesity on Severity Knee Osteoarthritis Refangga Lova Nusantara Efendi; Zulfachmi Wahab; M. Riza Setiawan
MAGNA MEDIKA: Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 3 (2016): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.944 KB) | DOI: 10.26714/magnamed.1.3.2016.64-68

Abstract

Background: Obesity can affect severity of knee osteoarthritis sufferers. Several studies have examined relationship between obesity and osteoarthritis, but no one has examined the different types of obesity on osteoarthritis, therefore, researchers wanted to know differences of central and peripheral obesity on severity osteoarthritis.Methods: A retrospective studi, with cross-sectional, simple random sampling method, conducted between 1 August 2014 and 30 September 2014 in Semarang City. Samples people > 50 years old. Data were analyzed by rank Spearman and Anova correlation.Results: In this study, 45.7% (n = 32) reported severe osteoarthritis. The results of the statistical test obtained p1 = 0,000 (reject Ho). The correlation coefficient (r) is 0.857 (strong), and the linear pattern is positive. The coefficient of determination (r2) is obtained (0.857) 2 = 0.73 = 73%. And 37.1% (N = 26) reported being obese. p2 = 0.043 (reject Ho). The mean deviation (MD) was 0.048 (not significant) between central obesity and peripheral obesity.Conclusion: Obesity affects severity of knee osteoarthritis. The greater body mass index, greater severity of knee osteoarthritis. 73% of severity of knee osteoarthritis is influenced by obesity, but there is no significant effect between central and peripheral obesity on the occurrence of knee osteoarthritis.
Ankle Brachial Index pada Penderita Diabetes dan Non Diabetes, dan Hubungannya dengan Aktivitas Fisik dan Perilaku Merokok Arum Kartikadewi; Setyoko Setyoko; Zulfachmi Wahab; Kharisma Andikaputri
Jurnal Kedokteran dan Kesehatan Vol 18, No 1 (2022): JURNAL KEDOKTERAN DAN KESEHATAN
Publisher : Faculty of Public Health, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/jkk.18.1.57-68

Abstract

Ankle Brachial Index (ABI) adalah prediktor utama untuk menilai adanya penyakit arteri perifer pada penderita Diabetes Melitus (DM) dan non DM. Terdapat perbedaan faktor risiko terhadap abnormalitas ABI antara penderita DM dan non DM. Penelitian bertujuan mengetahui perbedaan faktor yang mempengaruhi ABI pada penderita DM dan non DM etnis Jawa.Desain penelitian adalah observasional analitik dengan pendekatan case control. Sampling dilakukan dengan cara consecutive sampling. Perbedaan faktor yang mempengaruhi ABI dianalisis dengan  uji Chi-square. Faktor yang signifikan mempengaruhi ABI pada responden DM adalah usia (p-value=0,04) dan aktivitas fisik (p-value=0,02) dan faktor yang tidak signifikan adalah jenis kelamin (p-value=1,00), lama DM (p-value=0,31), tekanan darah (p-value=0,75), dan status merokok (p-value=1,00). Sedangkan, faktor yang signifikan mempengaruhi ABI pada responden non DM adalah aktivitas fisik (p-value=0,01) dan faktor yang tidak signifikan adalah jenis kelamin (p-value=0,31), usia (p-value=0,08), tekanan darah (p-value=0,93), dan status merokok (p-value=0,32). Faktor yang mempengaruhi ABI pada responden DM adalah usia dan aktivitas fisik, sedangkan pada responden non DM adalah aktivitas fisik.
Korelasi Indeks Massa Tubuh dan Tekanan Darah dengan Rasio TG/HDL pada Penderita Diabetes Mellitus Tipe 2 Etnis Jawa: Correlation of Body Mass Index and Blood Pressure with TG/HDL Ratio in Type 2 Diabetes Javanese Patients Yanuarita Tursinawati; Lilis Setiowati; Zulfachmi Wahab; Arum Kartikadewi
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.817

Abstract

LATAR BELAKANG: Salah satu komplikasi makrovaskuler penderita diabetes melitus tipe 2 (DMT2) yaitu penyakit jantung koroner (PJK). Kematian utama pada DMT2 disebabkan karena PJK. Rasio trigliserida (TG)/ high density lipoprotein (HDL) dapat memprediksi perkembangan PJK dan berkorelasi dengan indeks massa tubuh (IMT) dan tingkat tekanan darah. TUJUAN: Penelitian ini bertujuan membuktikan korelasi IMT dan tekanan darah dengan rasio TG/HDL penderita DMT2 Etnis Jawa. METODE : Sampel penelitian sejumlah 107 subjek DMT2 etnis Jawa. Data sekunder berupa rekam medis pasien DMT2 di Puskesmas, Semarang. Uji korelasi Spearman dipakai untuk menganalisis korelasi IMT dan tekanan darah dengan rasio TG/HDL dengan p<0,05. HASIL: Pada DMT2 etnis Jawa ditemukan rerata IMT adalah 24,3 + 3,3 kg/m2 dengan mayoritas IMT obesitas (42,1%), rerata tekanan darah sistolik (138,4+19 mmHg) dan tekanan darah diastolik (80,5+8,9 mmHg) dengan mayoritas mengalami prehipertensi (46,7%). Terdapat korelasi positif lemah yang signifikan antara IMT terhadap rasio TG/HDL pada penderita DMT2 etnis Jawa (r= 0,262, p= 0,006). Tekanan darah tidak terdapat korelasi signifikan terhadap rasio TG/HDL pada penderita DMT2 etnis Jawa (r= -0,114, p=0,243,). KESIMPULAN: Terdapat korelasi signifikan antara indeks massa tubuh (IMT) dengan rasio TG/HDL pada penderita DMT2 etnis Jawa. Sedangkan tingkat tekanan darah tidak berkontribusi terhadap rasio TG/HDL pada penderita DMT2 etnis Jawa. KATA KUNCI: Indeks massa tubuh, tekanan darah, rasio TG/HDL, DMT2
Hubungan antara Kadar HbA1c dan Derajat Retinopati Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Mata Cicendo Bandung Fathia Farhani; Zulfachmi Wahab; Yanuarita Tursinawati
Jurnal Kesehatan Andalas Vol 12, No 1 (2023): Online March 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2157

Abstract

Diabetic retinopathy is the common complication of T2DM, which leads to vision loss. The severity of retinopathy can be affected by HbA1c levels. Controlling the glycemic such as HbA1c, may prevent the severity of diabetic retinopathy. Objective: To identified the association between HbA1c levels and severity of retinopathy in Type 2 DM patients at Cicendo Eye Hospital, Bandung. Methods: This research was an analytic observational study and cross-sectional approach. Samples were taken using purposive sampling and consisted of 70 people. The secondary data were from the outpatient's medical records at the Cicendo Eye Hospital in Bandung for the period September-October 2022. The Chi-square test was used for data analysis. Results: According to HbA1c levels, the uncontrolled HbA1C levels were found in 52 patients (74,3%) and the controlled were found in 18 patients (25,7%). Most of them were diagnosed with PDR were found 62% and the rest of it were diagnosed with NPDR. A significant association is found between HbA1c levels and the degree of diabetic retinopathy with p-value = 0.018 (p <0.05). Conclusion: HbA1c levels in Type 2 Diabetes Mellitus patients have a significant association with the severity of diabetic retinopathy, which can be used as a parameter for controlling diabetes complications, particularly retinopathy.Keywords: diabetic retinopathy, T2DM, HbA1c, glycemic control
KORELASI HbA1c DAN GULA DARAH PUASA TERHADAP RASIO TG/HDL-K PASIEN DIABETES MELLITUS TIPE 2 BERETNIS JAWA Yanuarita Tursinawati; Sakinah; Zulfachmi Wahab; Arum Kartikadewi
Bina Generasi : Jurnal Kesehatan Vol 15 No 1 (2023): Bina Generasi : Jurnal Kesehatan
Publisher : LPPM STIKES BINA GENERASI POLEWALI MANDAR

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35907/bgjk.v15i1.259

Abstract

Background : Most of the causes of death in type 2 Diabetes Mellitus (T2DM) are coronary heart disease (CHD) with dyslipidemia as one of its risk factors. The best marker for early detection of dyslipidemia is the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C). In T2DM patients, glycemic control in the form of Fasting Blood Sugar (GDP) and HbA1c can be done to avoid the risk of CHD. This study aims to identify the correlation of Hba1c and GDP with the ratio of TG/HDL-K in T2DM patients with Javanese ethnicity.Methods : This research was a cross sectional study involving 107 respondents from several health centers in Semarang City with consecutive sampling method. GDP, HbA1c, and TG/HDL-K ratio were obtained from medical records. Spearman correlation statistical test was used with a significance value of p <0.05. Results: The average HbA1c (7.86 ±1.97%), GDP (160.36± 76.82gr/dL), and the TG/HDL-K ratio (3.50± 2.22) exceeded the normal number. There was a weak significant correlation between GDP and the TG/HDL-K ratio (p=0.020; r=0.224) and there was no correlation between HbA1c and the TG/HDL-K ratio (p=0.549; r=0.059) in T2DM patients with Javanese ethnicity.Conclusion: The GDP of Javanese T2DM patients is weakly correlated with the TG/HDL-K ratio but not with HbA1c. Glycemic control is needed as an early marker of CHD risk in T2DM.
Co-Authors Arum Kartikadewi Arum Kartikadewi Arum Kartikadewi Augatha, Arrafli Bagas Fathia Farhani Kanti Ratnaningrum Kharisma Andikaputri Lilis Setiowati M. Riza Setiawan Refangga Lova Nusantara Efendi Sakinah Setyoko Setyoko Yanuarita Tursinawati Yanuarita Tursinawati Yanuarita Tursinawati