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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Human Nutrition JURNAL PHOTON Oto Rhino Laryngologica Indonesiana BKM Public Health and Community Medicine
Surono, Agus
Departemen Ilmu Kesehatan Telinga Hidung Tenggorok- Bedah Kepala Leher Fakultas Kedokteran Universitas Gadjah Mada/ Rumah Sakit Dr. Sardjito Yogyakarta
Agriculture, Biological Sciences & Forestry Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Status Gizi sebagai Prediktor Kualitas Hidup Pasien Kanker Kepala dan Leher Kurniasari, Fuadiyah Nila; Surono, Agus; Pangastuti, Retno
Indonesian Journal of Human Nutrition Vol 2, No 1 (2015)
Publisher : Jurusan Gizi, Fakultas Kedokteran, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (483.669 KB) | DOI: 10.21776/ub.ijhn.2015.002.01.6

Abstract

AbstrakPrevalensi kanker kepala leher (KKL) di Indonesia cukup tinggi dengan prevalensi 4,7 per 100.000 penduduk. Pasien kanker berisiko tinggi terhadap gizi kurang, dimana status gizi berpengaruh terhadap kualitas hidup dan perasaan nyaman pada pasien. Penelitian ini bertujuan untuk mengetahui berbagai indikator status gizi yang dapat digunakan untuk memprediksi kualitas hidup pasien KKL. Penelitian ini merupakan penelitian observasional dengan rancangan potong lintang yang dilakukan di RS Saiful Anwar Malang selama bulan Nopember 2010 – Januari 2011. Subjek yang diteliti adalah pasien KKL yang memenuhi kriteria inklusi sebanyak 45 subjek. Status gizi ditentukan melalui 3 metode, yaitu indeks massa tubuh (IMT), Subjective Global Assessment (SGA), dan asupan makanan. Pengumpulan data dilakukan dengan cara wawancara dan pemeriksaan. Analisis bivariat menggunakan Chi Square dan multivariat menggunakan regresi linier ganda. Terdapat hubungan yang signifikan antara SGA kategori A (β1=30,631; p=0,001), asupan protein (β2=0,344; p=0,009), IMT (β3=-1,533; p=0,028), dan SGA kategori B (β4=13,353; p=0,039) dengan kualitas hidup pasien KKL dengan konstanta multivariat sebesar 47,086. Asupan energi terwakili oleh asupan protein, dimana hubungan keduanya adalah sinergis. Tidak terdapat hubungan antara asupan vitamin A dengan kualitas hidup (β5=0,000; p=0,907). Sehingga status gizi dapat digunakan sebagai prediktor untuk menentukan skor kualitas hidup pasien KKL yaitu dengan formula: kualitas hidup pasien KKL = 47,1 + 30,6 (jika SGA A) + 0,3 (asupan protein (g)) – 1,5 (IMT (kg/m2)) + 13,3 (jika SGA B).  Status gizi yang dinilai dengan IMT, asupan protein, dan SGA dapat digunakan untuk memprediksi besarnya skor kualitas hidup pasien KKL, dimana SGA merupakan faktor yang paling berpengaruh dalam menentukan kualitas hidup pasien KKL.Kata Kunci: indeks massa tubuh, asupan energi, protein, vitamin A, subjective global assessment (SGA), kualitas hidup, kanker kepala dan leher AbstrakIn Indonesia cancer is the seventh cause of mortality. The prevalence of the Head and Neck Cancer (HNC) in Indonesia is high (4,7/100.000). Cancer patients have high risk for weight loss and malnutrition, where nutritional status affects quality of life and comfortable feeling in cancer patients. Determining the nutritional status indicators can be used to predict the quality of life of patients with head and neck cancer. The study was observational with cross sectional design in Saiful Anwar Hospital, Malang in November 2010 – January 2011. Subjects were HNC patients that met inclusion criteria (n=45). Nutritional status was determined with 3 methods, which are body mass index (BMI), subjective global assessment (SGA), and dietary intake assessment. Interview, weight and height measurement and physical examination were held to collect data. Chi square and linier regression analysis were used to get data analysis. There was a significant correlation between SGA of category A (β1=30,631; p=0.001), intake of protein (β2=0,344; p=0.009), body mass index (β3=-1,533; p=0.028), and SGA of category B (β4=13,353; p=0.039) with quality of life of head and neck in cancer patients. Intake of energy was represented from intake of protein whereby both were mutually supportive. There was no correlation between intake of vitamin A and quality of life (β5=0,000; p=0.907).The nutritional status can be used as a predictor for determining the quality of life scores of head and neck cancer patients, with the formula is: quality of life of HNC patients =47.1+30.6(if SGAA) +0.3(protein intake (g)) -1.5(BMI (kg/m2)) +13.3(if SGAB). Nutritional status was assessed by BMI, intake of protein, and SGA can be used to predict the quality of life scores in head and neck of cancer patients, where SGA is the most influential factor in determining the quality of life of patients with head and neck cancer. Keywords: body mass index, intake of energy, protein, vitamin A, subjective global assessment, quality of life, head and neck cancer
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN STRES KERJA PADA DOSEN TETAP DI STIKES Y BENGKULU Aprianti, Rina -; Surono, Agus -
Sistem Informasi Vol 9 No 1 (2018): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.637 KB)

Abstract

Stres kerja adalah suatu keadaan yang dialami seseorang akibat dari kombinasi sumber stres di tempat kerja, karakteristik individu, dan stres di luar dari organisasi. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan stress kerja pada dosen tetap di STIKES Y Bengkulu. Jenis penelitian ini adalah penelitian survei analitik dengan pendekatan cross sectional. Sampel dalam penelitian ini adalah dosen tetap di STIKES Y Bengkulu yang berjumlah 36 orang. Variabel bebasnya adalah umur, status pernikahan dan jumlah anak, variabel terikatnya adalah stres kerja. Analisis yang digunakan adalah chi square dan fisher exact, yaitu untuk menguji ada tidaknya hubungan antara variabel bebas dan terikat. Hasil penelitian ini terdapat: hubungan yang signifikan secara statistik antara umur (p= 0,001 ) dengan stres kerja. Tidak ada hubungan yang signifikan secara statistik antara status pernikahan (p= 0,069), jumlah anak (p= 0,073) dengan stres kerja.
Expression of Tumor Necrosis Factor - α (TNF-α) and Interleukin 1-β (IL1-β) in Chronic Tubotympanic Suppurative Otitis Media Anton Budhi Darmawan; Marsetyawan HNE Soesatyo; Ratna Dwi Restuti; Agus Surono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.283 KB) | DOI: 10.19106/JMedScieSup0050012018020

Abstract

Chronic Suppurative Otitis Media (CSOM) is a common public health problem worldwide and a major cause of hearing impairment. It is also one of the neglected disease especially in developing countries. Cytokines are a group of glycoproteins that play a role in strengthening the immune and inflammatory reactions in various diseases, including inflammation of the middle ear. Some of the important inflammatory mediators found in middle ear fluids are Tumor Necrosis Factor-α (TNF-α) and Interleukin-1β (IL-1β). Cytokines are thought to play a role in the ongoing inflammatory regulation. The aim of this study was to compare the expression of TNF-α and IL-1β in tubotympanic CSOM and in healthy control group. The mean of TNF-α serum level in tubotympanic CSOM was 0,553±1,59 pg/ ml, and 0,587±2,13 pg/ ml in control group. There was no statistically different of TNF-α between two groups (P > 0,05). Mean of IL-1β serum level in the tubotympanic CSOM and control group were 0,633±0,92 and 0,302±0,48, respectively. Although IL-1β levels were higher in the patient group, the difference was not statistically significant (P > 0,05).
Sequence variation of latent membrane protein 2A (LMP2A)gene from Epstein-Barr virus epitope cytotoxic T-lymphocyte (CTL)related to human leucocyte antigen-A24 (HLA-A24)in peripheral blood sample and cytobrushof nasopharyngeal cancer patients Maya Esther Wullur Moningka; Agus Surono; Sofia Mubarika
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 2 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (343.639 KB) | DOI: 10.19106/JMedSci005102201905

Abstract

Epstein-Barr virus (EBV) infects lymphocyte B and triggers latent phase in the host so that it causes nasopharyngeal carcinoma (NPC). Latent membraneprotein 2A (LMP2A) epitope CTL-HLA-A24 is a target for recognition by cytotoxic T lymphocyte(CTL). The change in the epitope could influence the latency of particular EBV in the host due toits ability to evade immune surveillance mediated by CTL. The study aimed to determine thesequence variation of LMP2A epitope CTL-HLA-A24 gene from the peripheral blood samples and cytobrush of the NPC patients. Case-series study was conducted with total 16 cytobrush samples from NPC patients. DNA isolation, polymerasechain reaction (PCR) and gene sequencing were performed in this study. From cytobrush samples of NPC patients, it was found the changes of base sequence variation of LMP2A gene from GGC>GGA, CCA>CCC, TGC>TCC, GGT>GGC and TCT>ACT. CCA>CCC and TGC>TCC variations were found in epitope associated with HLA-A2 where there was a change of epitope sequence from TYGPVFMCL to TYGPVFMSL caused by missense mutation. The change of base sequence caused amino acid alteration from cysteine to serine. Whereas the variation of CCA>CCC did not change the sequence of amino acid proline so that the epitopewas unaffected. In epitope associated HLA-A2 (CLGGLLTMV), there was a change in base sequence from GGT to GGC, but there was no changes in amino acid and still as glycine. There were some new variations: in the upstream sequence of LMP2A from GGC>GGA which is silent mutation and the other variation is in downstream sequence of LMP2A from TCT>ACT which is missense mutation. Thesequence variations of LMP2A gene found in this research were GGC>GGA, CCA>CCC, TGC>TCC, GGT>GGC and TCT>ACT. In our research, we found another variation compared the previous research. The variation was in the upstream sequence of LMP2A from GGC>GGA which is silent mutation and the other variation is in the downstream sequence of LMP2A from TCT>ACT which is missense mutation.
Hubungan ekspresi p53, Bcl-2, c-Myc dan MMP-9 dengan gambaran klinikopatologi karsinoma sel skuamosa kepala-leher Azwar Azwar; Sofia Mubarika; Agus Surono
Oto Rhino Laryngologica Indonesiana Vol 46, No 1 (2016): Volume 46, No. 1 January - June 2016
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1152.508 KB) | DOI: 10.32637/orli.v46i1.147

Abstract

Latar belakang: Karsinoma sel skuamosa kepala dan leher merupakan salah satu kanker terseringdi seluruh dunia. Pendekatan pengobatan agresif dan multidisiplin telah dilakukan, namun belum adapeningkatan yang signifikan dalam kelangsungan hidup 5 tahun, selama 20 tahun terakhir. Kegagalanpengobatan terjadi dalam bentuk kekambuhan lokoregional, metastasis jauh, dan/atau tumor primer kedua.Berbagai penanda molekular tumor telah diteliti untuk mengetahui potensinya dalam memprediksi hasilpenyakit atau respon terhadap terapi.Tujuan: Mengetahui hubungan ekspresi protein p53, Bcl-2, c-Myc,dan MMP-9 berdasarkan gambaran klinikopatologis karsinoma sel skuamosa kepala dan leher di RumahSakit dr. Zainoel Abidin.Metode: Studi menggunakan desain cross sectional. Sampel terdiri dari 60blok parafin karsinoma sel skuamosa kepala dan leher. Prosedur pewarnaan imunohistokimia dilakukandengan menggunakan antibodi monoklonal terhadap p53, Bcl-2, c-Myc, dan MMP-9. Ekspresi proteinp53, Bcl-2, c-Myc, dan MMP-9 dianalisis secara imunohistokimia pada karsinoma sel skuamosa kepaladan leher kemudian hasilnya dihubungkan dengan parameter klinikopatologis seperti usia, jenis kelamin,lokasi tumor, diferensiasi tumor, metastasis kelenjar getah bening dan stadium tumor, kemudian dianalisisstatistik dengan Chi square.Hasil: Hasil penelitian menunjukkan terdapat hubungan bermakna tingkatekspresi p53 dengan metastasis lokal (p=0,021) dan ada hubungan bermakna tingkat ekspresi MMP-9dengan lokasi tumor (p=0,026). Tidak terdapat hubungan ekspresi p53, Bcl-2, cMyc, dan MMP-9 terhadapusia, jenis kelamin, stadium tumor, diferensiasi histologi, tingkat T, N, dan metastasis jauh.Kesimpulan:Ada hubungan ekpresi p53 dengan metastasis kelenjar limfe regional dan ekspresi MMP-9 dengan lokasitumor pada karsinoma sel skuamosa kepala dan leher. Kata kunci: Karsinoma sel skuamosa kepala dan leher, p53, Bcl-2, c-Myc, MMP-9 ABSTRACTBackground: Head and neck squamous cell carcinoma (HNSCC) is one of the most commoncancers world wide. Although aggressive and multidisciplinary approach to the treatment has been done,there is no significant improvement in 5-year survival in the last 20 years. Treatment failure occurredin the form of locoregional recurrence, distant metastasis, and/or a second primary tumor. A variety oftumor molecular markers have been studied to determine their potential in predicting disease outcome orresponse to the therapy. Purpose: To investigate correlation p53, Bcl-2, c-Myc, and MMP-9 expressionto clinicopathologic parameter in head and neck squamous cell carcinoma patient in dr. Zainoel Abidinhospital. Methods: Cross sectional design study. The sample was consisted of 60 paraffin blocks ofhead and neck squamous cell carcinoma. Procedure of immunohistochemical staining used monoclonalantibodies against p53, Bcl-2, c-Myc, and MMP-9. Expression of p53 protein, Bcl-2, c-Myc, and MMP-9were analyzed by immunohistochemistry in head and neck squamous cell carcinoma. Then, the results were linked to clinicopathologic parameters such as age, sex, tumor location, tumor differentiation,lymph node metastasis and tumor stage, and statistically analyzed with Chi square. Results: The resultsshowed there were significant correlation between p53 expression level with local metastasis (p=0,021)and significant correlation of MMP-9 expression levels with tumor location (p=0,026). There were norelationship of p53, Bcl-2, cMyc and MMP-9 expressions based on age, sex, stage tumor, histologicdifferentiation, level of T, N, and distant metastases. Conclusion: There were relationships between p53expression with local metastasis and MMP-9 expression with tumor location in head and neck squamouscell carcinoma. Keywords: Head and neck squamous cell carcinoma, p53, Bcl-2, c-Myc, MMP-9
Work stress, age, and years of service with feeling of work fatigue among nurses at Grhasia hospital Yogyakarta Angelina Candra Dewi; Agus Surono; Adi Heru Sutomo
Berita Kedokteran Masyarakat (BKM) Vol 32, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.642 KB) | DOI: 10.22146/bkm.8569

Abstract

Work stress, age, and years of services with work fatigue among nurses at mental hospital of Grhasia YogyakartaPurposeThis research aimed to find associated factors of working stress, age, and working length with fatigue feelings among nurses at mental hospital of Grhasia Yogyakarta. MethodsA cross-sectional study was conducted using data sheets, job stress questionnaire, and KAUPK2 questionnaire given to 55 nurses. Research data were analyzed using Pearson product moment and multiple linear regression tests. ResultsWork stress correlated with work fatigue feelings with value r=0.454, p-value<0.05, age correlated with feelings of work fatigue with value r=0.334, p-value<0.05, and working relationship with feelings of work fatigue with value r=0.361, p-value<0.05. The results of multiple regression analysis indicated that job stress and work period have a significant relationship and are the factors that most play a role in determining feelings of work fatigue among nurses (R2=0.275, p=0.000).ConclusionThere was a correlation between work stress, age, and work period with feelings of work fatigue among nurses, and there were influences simultaneously between work stress and work period with feeling of work fatigue. It is recommended for hospitals to conduct recreational activities or rotate work for senior and less productive nurses with junior and productive nurses. This policy aims to eliminate boredom and work fatigue. In addition, nurses are expected to perform and improve healthy lifestyles, by performing routine medical check ups, eating food with a balanced diet and getting adequate rest.
Interaksi interpersonal dan stres kerja dosen di STIKES X Bengkulu Rina Aprianti; Agus Surono
Berita Kedokteran Masyarakat (BKM) Vol 33, No 10 (2017)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (495.149 KB) | DOI: 10.22146/bkm.25088

Abstract

Interpersonal interaction and lecturer work stress in private universityPurposeThis paper discussed how and why the weakness of interpersonal interaction can lead to lecturer work stress.MethodThis analytic survey research was conducted with a cross-sectional approach involving 36 permanent lecturers of a private university. The independent variables were the working period and interpersonal interaction, the dependent variable was the work stress.ResultsThis paper found 50% of lecturers still lack interpersonal interaction. The problem was in communication among lecturers and university leaders, and awareness to build interpersonal interaction in the work environment. Lecturers with good interpersonal interactions have lower stress levels. Social support is very useful to strengthen the psychological aspects of lecturers in their activities.ConclusionThis paper concluded the relationship between interpersonal interaction with work stress. University need to regularly facilitate joint agenda for all staff to encourage close interpersonal interaction.
Analisis komitmen manajemen terhadap kesiapsiagaan menghadapi bencana gempa bumi di RSUD Dr. M. Yunus Bengkulu Ika Ambar Trisnawati; Agus Surono; Adi Heru Sutomo
Berita Kedokteran Masyarakat (BKM) Vol 35, No 4 (2019): Proceedings the 5th UGM Public Health Symposium
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1109.233 KB)

Abstract

Latar Belakang : Kota Bengkulu merupakan daerah rawan terhadap bencana karena terletak pada pertemuan lempeng tektonik Samudera Hindia dan lempeng tektonik Asia yang menyebabkan rawan bencana gempa bumi dan tsunami. Rumah sakit dapat menjadi tidak berfungsi disaat keadaan darurat apabila terjadi kegagalan struktural ataupun ketidaksiapan tim pelayanan kesehatan dalam menyelamatkan nyawa orang yang menjadi korban saat bencana gempa terjadi. Komitmen manajemen rumah sakit merupakan suatu hal yang sangat penting dalam keberhasilan melaksanakan kegiatan kesiapsiagaan dalam menghadapi bencana gempa bumi di rumah sakit.Tujuan Penelitian : Mengkaji komitmen manajemen dilihat dari aspek kebijakan yang dibuat, pengalokasian pembiayaan serta sarana dan prasarana dalam pelaksanaan kesiapsiagaan menghadapi bencana gempa bumi di RSUD Dr. M. Yunus Bengkulu. Metode Penelitian : Penelitian ini merupakan penelitian kualitatif dengan rancangan penelitian studi kasus. Pelaksanaan penelitian dilakukan dengan wawancara mendalam, telaah dokumen, dan observasi lapangan. Penentuan subyek penelitian dilakukan dengan menggunakan teknik purposive sampling. Responden terdiri dari 12 responden dari RSUD Dr. M. Yunus Bengkulu, 2 orang dari BPBD dan 1 orang dari Dinas Kesehatan Provinsi Bengkulu.Hasil Penelitian: RSUD Dr. M. Yunus Bengkulu telah melaksanakan upaya kesiapsiagaan bencana internal rumah sakit sejak tahun 2016. Secara keseluruhan pelaksanaan program kesiapsiagaan menghadapi bencana di RSUD Dr. M. Yunus Bengkulu sudah berjalan, akan tetapi dukungan manajemen dari aspek pembiayaan  masih belum maksimal. Komitmen atau dukungan manajemen dari aspek penyediaan sarana dan prasarana ditunjukkan dengan tersedianya fasilitas, SDM, sarana dan prasarana yang menunjang kesiapsiagaan rumah sakit dalam menghadapi bencana gempa bumi.  Penyediaan fasilitas, SDM, dan sarana prasarana ini masih perlu ditingkatkan lagi oleh pihak manajemen RSUD Dr. M. Yunus Bengkulu.Kesimpulan: Manajemen RSUD Dr. M. Yunus Bengkulu berkomitmen dalam pelaksanaan kesiapsiagaan menghadapi bencana gempa bumi yang ditunjukkan dengan sudah ada kebijakan yang mengatur tentang kesiapsiagaan bencana di rumah sakit. Akan tetapi dukungan dari aspek pembiayaan belum maksimal sehingga menghambat setiap kegiatan, peningkatan SDM, penyediaan fasilitas serta sarana prasarana yang dibutuhkan. Jajaran manajemen perlu melakukan koordinasi dan menjalin kerjasama secara tertulis dengan Dinas Kesehatan, Dinas Sosial dan BPBD dalam menyusun kebijakan dan pembiayaan untuk kesiapsiagaan rumah sakit dalam menghadapi bencana gempa bumi di RSUD Dr. M.Yunus Bengkulu.
Co-Authors Adi Heru Sutomo Adi Heru Sutomo Ahmad Imanuddin Angelina Candra Dewi Anton Budhi Darmawan Aprianti, Rina Asrul Sani Azwar Azwar Fuadiyah Nila Kurniasari Ika Ambar Trisnawati Koeswardani, Millani Amastasia Lia Agustina, Lia Marsetyawan HNE Soesatyo Maya Esther Wullur Moningka Nur Arfian, Nur Rahmani, Noor Siti Ratna Dwi Restuti Retno Pangastuti Rina Aprianti Sofia Mubarika Sofia Mubarika Tunika, Puriwati Wijaya, Muhammad Harry