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All Journal Pharmacon Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi
Setiani, Lusi Agus
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Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Engineering Health Professions Medicine & Pharmacology

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PENENTUAN KADAR FLAVONOID EKSTRAK ETANOL 70% KULITBAWANG MERAH (Allium cepa L.) DENGAN METODE MASERASI DAN MAE (Microwave Assisted Extraction) Setiani, Lusi Agus; Sari, Bina Lohita; Indriani, Lusi; Jupersio, Jupersio
FITOFARMAKA | Jurnal Ilmiah Farmasi Vol 7, No 2 (2017): Vol.7, No.2, Desember 2017
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.983 KB)

Abstract

ABSTRAKKulit bawang merah mengandung senyawa flavonoid, polifenol, saponin, terpenoid dan alkaloid. Golongan flavonoid yang terdapat pada kulit bawang merah adalah flavonol yang berkhasiat sebagai antioksidan kuat serta diketahui dapat mengurangi risiko tumor, kanker, penyakit jantung, stroke, bronchitis, asma dan anti peradangan. Penelitian ini bertujuan untuk menentukan dan membandingkan kadar flavonoid ekstrak etanol 70% kulit bawang merah  menggunakan metode maserasi dan MAE (Microwave Assited Extraction). Metode ekstraksi maserasi dilakukan pada suhu kamar dan MAE pada suhu 80ºC. Kadar flavonoid diukur menggunakan alat spektrofotometri UV-VIS  dengan  reagen  AlCl3.      Senyawa  standar  flavonoid  yang digunakan adalah kuersetin. Kadar flavonoid yang didapatkan dengan metode maserasi adalah sebesar 14,92% dan kadar flavonoid yang didapatkan dengan metode MAE adalah sebesar 17,18%.   Dari data ini dapat disimpulkan bahwa metode MAE  (Microwave Assited  Extraction)  lebih  efektif digunakan  untuk  mengekstrak  flavonoid  dari kulit bawang merah dibandingkan dengan metode maserasi. Kata Kunci: Kulit bawang merah, maserasi, MAE, flavonoid
Activity of Antioxidant and Inhibitor α-Glucosidase Instant Granul Ethanol Tea Leaf Extract (Camellia sinensis) and Tea Benalu (Scurulla atropurpureea BL Dans) Setiani, Lusi Agus; Sari, Bina Lohita
Journal of Science Innovare Vol 1, No 01 (2018): Journal of Science Innovare
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.824 KB) | DOI: 10.33751/jsi.v1i01.676

Abstract

Tea leaves are plants that are widely spread especially in the area of West Java, while parasites are parasitic plants in tea trees that empirically have various properties such as antioxidants and anti diabetic. The α-glucosidase inhibitor is one of the therapeutic drugs for diabetic that works by inhibiting carbohydrate metabolism. Instant granule preparation is one form of dosage used by dissolving in water. This study aims to determine the antioxidant activity and inhibitors of instant granular α-glucosidase ethanolic extract of Tea and Tea Tea leaves. The extract was obtained from extraction with 60% ethanol solvent-assisted extraction (MAE) method. Research was done by making 3 formula (Formula 1, 2 and 3) with comparison of tea leaf extract, parasite, Polivinil pyrrolidone (PVP) and cyclodextrin ie 26,88%, 1,8%, 2%, 0% (Formula 1) 26.88%, 0%, 3%, 12% and 0% (Formula 2), 1.8%, 4%, 15% (Formula 3). Formula 2 is active as an antioxidant and α-glucosidase enzyme inhibitor with IC50 values of 68.21 and 56.76 ppm. Keywords: Tea Leaves, Benalu Tea, Antioxidants, α-glucosidase Inhibitors, Instant Granules
UJI AKTIVITAS ANTIINFLAMASI INFUSA DAUN AFRIKA (VERNONIA AMYGDALINA) PADA TIKUS PUTIH YANG DIINDUKSI KARAGENAN Setiani, Lusi Agus; Moerfiah, Moerfiah; Yulianita, Yulianita
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9322

Abstract

Inflammation is one of the immune system's main responses to infection and irritation. One of the medicinal plants that can be used as anti-inflammatory is African leaves because there have flavonoid compounds. Flavonoid compounds have anti-inflammatory effects that can regulate arachidonic acid metabolism by inhibiting cyclooxygenase (COX) and lipooxygenase activity.This study aims to determine the effectiveness and determine the effective dose of African leaf infusion as anti-inflammatory in sparague dawley strain  induced carrageenan male white rats. The method used is measurement of udema with subplantar 1% carrageenan induction.Test animals used were 20 male rats divided into 5 groups. Each group consisted of 4 rats. Group I as a negative control was given CMC-Na solution, the second group as a positive control was given diclofenac sodium with 1.26 mg/200 gBB body weight, group III, IV and V were given African leaf infusion with three dose ratings namely 100, 150, 200 mg/kgBB bodyweight. The results showed that the infusion of African leaves had Antiinflammatory Activity with dose 200 mg/kg body weight as the most effective dose against inhibition of inflammation.           
Co-Authors Bina Lohita Sari Indriani, Lusi Jupersio, Jupersio MOERFIAH . Yulianita, Yulianita