VALENSI
Jurnal Kimia VALENSI Volume 5, No. 2, November 2019

Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD

Dewa Gede Katja (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University Kampus Kleak, Manado, 95115, North Sulawesi, Indonesia)
Desi Harneti (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University Jatinangor 45363, Indonesia)
Tri Mayanti (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University Jatinangor 45363, Indonesia)
Nurlelasari Nurlelasari (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University Jatinangor 45363, Indonesia)
Rani Maharani (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University Jatinangor 45363, Indonesia)
Yoshihito Shiono (Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University Tsuruoka, Yamagata 997-8555, Japan)
Unang Supratman (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University Jatinangor 45363, Indonesia)



Article Info

Publish Date
30 Nov 2019

Abstract

In the course of our continuing search for anticancer compounds from Chisocheton species, three steroids, stigmast-5-en-3β-ol (1), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (2) and stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (3), were obtained from the stembark of Chisocheton celebicus. The structures of compound 1-3 were identified with spectroscopic data including IR, 1D-NMR, 2D-NMR and TOF-MS, as well as by comparing with those spectral data previously. Compounds 1-3, were evaluated for their cytotoxic effects against P-388 murine leukemia cells and displayed the cytotoxicity activity with IC50 values of 12.45 ± 0.050, 52.27 ± 0.031 and 62.52 ± 0.076 µg/mL, respectively.

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Journal Info

Abbrev

valensi

Publisher

Subject

Chemistry

Description

Jurnal Kimia Valensi is a biannual and peer-reviewed open access journal published by Department of Chemistry, Faculty of Science and Technology UIN Syarif Hidayatullah Jakarta. This journal covering all aspect of ...