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Rani Maharani
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University Jatinangor 45363, Indonesia
Chemistry

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Cytotoxic Steroids From The Stembak of Chisocheton celebicus KOORD Dewa Gede Katja; Desi Harneti; Tri Mayanti; Nurlelasari Nurlelasari; Rani Maharani; Yoshihito Shiono; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 5, No. 2, November 2019
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.577 KB) | DOI: 10.15408/jkv.v5i2.12132

Abstract

In the course of our continuing search for anticancer compounds from Chisocheton species, three steroids, stigmast-5-en-3β-ol (1), stigmast-5-en-3β-ol-3-O-β-D-glucopyranoside (2) and stigmast-5,22-dien-3β-ol-3-O-β-D-glucopyranoside (3), were obtained from the stembark of Chisocheton celebicus. The structures of compound 1-3 were identified with spectroscopic data including IR, 1D-NMR, 2D-NMR and TOF-MS, as well as by comparing with those spectral data previously. Compounds 1-3, were evaluated for their cytotoxic effects against P-388 murine leukemia cells and displayed the cytotoxicity activity with IC50 values of 12.45 ± 0.050, 52.27 ± 0.031 and 62.52 ± 0.076 µg/mL, respectively.
Co-Authors Desi Harneti Putri Huspa Dewa Gede Katja Nurlelasari Nurlelasari Tri Mayanti Unang Supratman Yoshihito Shiono