Berkala Kedokteran
Vol 12, No 1 (2016)

Perbedaan Kadar LDH Serum Total Sebelum dan Sesudah Kemoterapi pada Berbagai Kelompok Stadium Kanker LNH

Hamidah Hamidah (Unknown)
Muh.Darwin Prenggono (Unknown)
Farida Heriyani (Unknown)



Article Info

Publish Date
02 May 2016

Abstract

Abstract: Lactate dehydrogenase (LDH) is tumor prognostic for Non Hodgkin Lymphoma (NHL) and it levels would be elevated. The several papers has reported there are an association of total serum LDH levels and staging group of NHL. The study aimed to determine the differences of total serum LDH levels before and after the combination chemotherapy CHOP (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) for NHL’s patients at RSUD Ulin Banjarmasin during 3 years. It was an observational analyticstudy design and cross-sectional approach, data collected with design method of totally sampling. Of the 51 patient medical records who included, 54,9% were staging group I-II and 45,1% were staging group III-IV. The first statistic analytic used dependent T test with p=0,303 (p>0,05)showed no differencesof total serum LDH levels before and after the combination chemotherapy CHOP in NHL’s patients with staging group I-II. The second statistic analytic used alternative wilcoxon test with p=0,013 (p<0,05) showed differencesof total serum LDH levels before and after the combination chemotherapy CHOP in NHL’s patients with staging groupIII-IV. The third statistic analytic used alternative mann whitney test with p=0,161 (p>0,05) showed no differencesof total serum LDH levels after the combination chemotherapy CHOP in NHL’s patients between staging group I-II and III-IV.Keywords: total serum LDH levels, NHL, combination chemotherapy CHOP Abstrak: Laktat dehidrogenase (LDH) adalah tumor prognostic pada kanker Limfoma Non Hodgkin (LNH) dan kadarnya selalu menunjukan peningkatan. Penelitian sebelumnya melaporkan bahwa terdapat hubungan antara kadar LDH serum total dengan kelompok stadium kanker LNH. Penelitian ini bertujuan untuk mengetahui perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP (Siklofosfamid, Doksorubisin, Vinkristin, dan Prednison) pada penderita kanker LNH di RSUD Ulin Banjarmasin selama 3 tahun.Penelitian ini menggunakan rancangan studi observasional analitik dan metode pendekatan cross sectional, pengambilan sampel dengan teknik rancangan totally sampling. Dari 51 data rekam medik yang termasuk kriteria inklusi, 54,9% kelompok stadium I-II dan 45,1% kelompok stadium III-IV. Analisis statistik pertama menggunakan uji T berpasangandengan p=0,303 (p>0,05) sehingga tidak terdapat perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH kelompok stadium I-II. Analisis statistik kedua menggunakan uji alternatif yaitu uji wilcoxondengan p=0,013 (p<0,05) sehingga terdapat perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH kelompok stadium III-IV. Analisis statistik ketiga menggunakan uji alternatif yaitu uji mann whitney dengan p=0,161 (p>0,05) sehingga tidak terdapat perbedaan kadar LDH serum total sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH antara kelompok stadium I-II dan III-IV. Kata-kata kunci: kadar LDH serum total, LNH, kemoterapi kombinasi CHOP

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Journal Info

Abbrev

jbk

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and ...