Jurnal Sains dan Teknologi Peternakan (JSTP)
Vol 1 No 1 (2019): Jurnal Sains dan Teknologi Peternakan

Ekstrak Etanol Daun Jati Belanda (Guazuma ulmifolia Lamk) Memperbaiki Profil Lipid Tikus (Rattus norvegicus) Wistar Jantan Dislipidemia

Melita Hidajat (Program Magister Biomedik, Fakultas Kedokteran, Universitas Udayana, Kampus Bukit, Jl. Raya Kampus Unud Jimbaran, Kec. Kuta Sel., Kabupaten Badung, Bali 80361)
I Gusti Made Aman (Departemen Farmakologi, Fakultas Kedokteran, Universitas Udayana, Kampus Bukit, Jl. Raya Kampus Unud Jimbaran, Kec. Kuta Sel., Kabupaten Badung, Bali 80361)
Hendro Sukoco (Prodi Peternakan, Fakultas Peternakan dan Perikanan, Universitas Sulawesi Barat, Jl. Prof. Dr. Baharuddin Lopa, S.H., Baurung, Banggae Timur, Baurung, Banggae Timur, Kabupaten Majene, Sulawesi Barat 91412)
Ferbian Milas Siswanto (Program Studi Bioteknologi, Fakultas Ilmu Kesehatan Sains dan Teknologi, Universitas Dhyana Pura, Jl. Raya Padang Luwih, Tegaljaya, Dalung, Kec. Kuta Utara, Kabupaten Badung, Bali 80361)



Article Info

Publish Date
01 Jan 2020

Abstract

The purpose of this study was to prove that the administration of Jati (Guazuma ulmifolia Lamk) leaves extract improves the lipid profile of dyslipidemic male Wistar rats. Subjects were 20 rats (Rattus norvegicus), male, Wistar strain, dyslipidemia (total cholesterol ≥ 200 mg dl-1), aged 2 months old, weighing 180-200 grams. The control group (10 rats) were given a placebo of 3 ml aquadest (P0) and the treatment group was given extracts of the Jati (Guazuma ulmifolia Lamk) leaves extract of 25 mg kg-1 BW (P1). Before and after treatment for 14 days, total cholesterol, triglyceride, LDL, and HDL levels were examined. The results showed that in the P0 group there were no changes in total cholesterol, triglyceride, LDL, and HDL levels (p>0.05), whereas the P1 group experienced a decrease in total cholesterol, triglyceride and LDL levels (p<0.05) and an increase in HDL levels (p<0.05). The results of this study indicated that the Jati leaves extract was effective to improve the lipid profile of dyslipidemic rats. It was necessary to compare the effectiveness of Jati leaves extract with synthetic dyslipidemia drugs used in the community such as statin.

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Journal Info

Abbrev

jstp

Publisher

Subject

Agriculture, Biological Sciences & Forestry Veterinary Other

Description

Jurnal Sains dan Teknologi Peternakan adalah jurnal ilmiah yang mencakup aspek ilmu hewan yang diterbitkan sejak tahun 2019, secara konsisten diterbitkan 2 kali dalam setahun pada bulan Juni dan Desember oleh Program Studi Peternakan, Fakultas Peternakan dan Perikanan, Universitas Sulawesi Barat ...