Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Vol 5, No 2 (2015)

Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L.

Artanti, Nina (Unknown)
Hanafi, Muhammad (Unknown)
Andriyani, Rina (Unknown)
Saraswaty, Vienna (Unknown)
Udin, Linar Zalinar (Unknown)
Lotulung, Puspa D (Unknown)
Fujita, Ken Ichi (Unknown)
Usuki, Yoshinosuke (Unknown)

Article Info

Publish Date
29 Jun 2015

Abstract

Hedyotis corymbosa, with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine.  The ethanol extract of H. corymbosa L. shows inhibitory activity to human YMB-1 breast cancer cell line with an IC50 of 6.51 mg/ml.  The methylene chloride fraction shows a potential cytotoxic activity with an IC50 of 2.75 mg/ml.  To obtain a lead compound, the extract was further purified by column chromatography. A pure compound is obtained which shows inhibitory activities against YMB-1, HL60 and KB human cell lines with IC50 values of 0.7; 11.0 and 104.2 mg/ml, respectively.  Based on the 1D and 2D FT-NMR data, the isolated compound is an asperuloside.

Copyrights © 2015




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Journal Info
Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Website

Abbrev

jtrolis

Publisher

Universitas Brawijaya

Subject

Agriculture, Biological Sciences & Forestry Environmental Science

Description

The Journal of Tropical Life Science (JTLS) provides publication of full-length papers, short communication and review articles describing of new finding or theory in living system, cells and molecular level in tropical life science and related areas. The journal publishes articles that report novel ...