Jurnal Medika Veterinaria
Vol 14, No 2 (2020): J.Med.Vet

9. The Effectiviteness of Jatropha salve (Jatropha curcas L) in Inflammatory Phase of cutaneous wound healing in Mice (Mus musculus) Histopathologically

Indra Sitorus (Program Studi Pendidikan Dokter Hewan Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
M Nur Salim (Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
Nazaruddin Nazaruddin (Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
Dwinna Aliza (Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
Denny Irmawati (Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
Awaluddin Awaluddin (Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
Cut Nila Thasmi (Laboratorium Reproduksi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
Muslim Akmal (Laboratorium Histologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)
Dian Masyitha (Laboratorium Histologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh)



Article Info

Publish Date
01 Feb 2021

Abstract

This study aims to determine the effectiveness of 10% Jatropha salve (Jatropha curcas L. )    to inflammation reaction cutaneous wound healing in mice (Mus musculus ) in the inflammatory phase. This experiment used 9 male mices, weighing 25-40 grams and age 2-3 months old, were divided into three treatment groups, each treatment consisting of three mices. The wound were made along 2 cms in the back area. Wound therapy was carried out  twice a day for 3 days.  Group KI was administered  and given by yellow vaseline, KII was given 10% Jatropha salve, and KIII was given gentamicin salve. The parameters measured are the increase in the number infiltrations of inflammatory cells,  neovascular, and re-epitelization. All quantitative data were measured using ANOVA and continued with Duncan Test, the qualitative data were presented descriptively by showing the results of observation under a microscope. The statistical test on the infiltrations of inflammatory cells and neovasculars parameter 10% Jatropha salve group significantly different (P0.05) compared to KI and KIII group. Histopatologycal observations indicated the 10% Jatropha salve could be reduce the infiltrations of inflammatory cells, increase neovasculars and re-epitelization percentage. According to the result can be concluded the 10% Jatropha salve can accelerate the inflammation phase cutaneous wound healing in mice.

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